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USATSI

The 2025 NFL season is upon us, and Week 1 is chock-full of intriguing matchups, starting with Thursday night's opener between the Dallas Cowboys and Philadelphia Eagles. There are plenty of big names on track to make headlines throughout the weekend, from Aaron Rodgers making his debut with the Pittsburgh Steelers and Micah Parsons taking the field as a Green Bay Packer to George Pickens catching passes opposite CeeDee Lamb for America's Team.

Not every notable name will actually be on the field when the NFL returns in full force, however. That's because injuries have already impacted all 32 clubs thanks to the toll of training camp and preseason.

Which ailments are most concerning? Which star players could be in danger of missing the first week of action? And which ones are set to play through pain as the season gets underway?

We've got you updated right here with final injury reports for each and every matchup on the Week 1 schedule, plus analysis regarding which key players are set to miss -- or suit up for -- their respective games:

NFL odds via FanDuel Sportsbook

Dallas Cowboys at Eagles (-8.5)

Two of the Cowboys' most important pieces on both sides of the ball are also now good to go: Pro Bowl cornerback Trevon Diggs (knee) and 2024 first-round pick left tackle Tyler Guyton (knee). Both of their respective availabilities for Thursday night were up in the air. Diggs has been recovering from a second knee procedure in as many years all offseason, and his work running with the scout team defense in practice helped get him up to speed. Guyton suffered a fractured bone and a sprained ligament in his knee at training camp, but he will also be able to return in time for Week 1 in Philadelphia.   

McKee's absence means the Eagles will enter the season with last-minute trade acquisition Sam Howell as Jalen Hurts' top backup. Rookie Kyle McCord is also on the team's practice squad, though he'd need to be promoted to the active roster to serve as an emergency third quarterback against Dallas. Better news for Philadelphia: Pro Bowl guard Landon Dickerson (back) and rookie safety Andrew Mukuba (hamstring) are both off the injury report, signaling their availability.

Chargers vs. Chiefs (-3) (Brazil)

Notable inclusions here: Marquise Brown (ankle) is good to go out wide for Kansas City, and running back Najee Harris (eye) is on track to make his Chargers debut despite missing most of the summer due to a fireworks accident. Other Chiefs on track to suit up despite recent injuries include right tackle Jawaan Taylor and new cornerback Kristian Fulton.

Detroit Lions at Green Bay Packers (-2.5)

The Green Bay Packers received mostly strong practice participation from their initial injury report on Wednesday. Quarterback Jordan Love (left thumb) practiced fully while new All-Pro edge rusher Micah Parsons (back), Pro Bowl center Elgton Jenkins (hip) and wide receiver Dontayvion Wicks (calf) were among those notably limited. Starting cornerback Nate Hobbs (knee) and starting wide receiver Jayden Reed (foot) were the two Packers to not practice on Wednesday.

The Detroit Lions didn't practice on Wednesday, but four players were listed as practice participant estimations: wide receiver Isaac TeSlaa (illness, limited), guard Kayode Awosika (shoulder, limited), linebacker Trevor Nowaske (elbow, did not participate) and running back Sione Vaki (hamstring, did not participate). 

Tampa Bay Buccaneers (-2.5) at Atlanta Falcons 

The Tampa Bay Buccaneers had a number of notable players pop up on their initial Wednesday injury report. Wide receiver Chris Godwin (ankle), edge rusher Haason Reddick (personal), defensive tackle Vita Vea (foot) and left tackle Tristan Wirfs (knee) all didn't practice. Tight end Cade Otton (groin) was limited.

The Atlanta Falcons only had four players on their entire Wednesday injury report. Two players -- safety DeMarco Rollins (hamstring) and offensive lineman Jack Nelson (calf) -- didn't practice, and two other players -- wide receiver Darnell Mooney (shoulder) and cornerback Clark Phillips III (rib) -- were limited.

Cincinnati Bengals (-5.5) at Cleveland Browns

The Cleveland Browns only had one player not practice on Wednesday: defensive tackle Mike Hall (knee). Cornerback Denzel Ward (shoulder), center Ethan Pocic (knee) and offensive tackle Joel Bitonio (rest) were limited.

The Cincinnati Bengals are fully healthy, declaring they have no injuries to report.  

Miami Dolphins at Indianapolis Colts (-1)

New Miami Dolphins tight end Darren Waller (hip) didn't practice on Wednesday and neither did second-year running back Jaylen Wright (knee). Starting running back De'Von Achane (calf), All-Pro wide receiver Tyreek Hill (oblique/calf) and right tackle Austin Jackson (toe) were limited in the first practice of the week. 

The Indianapolis Colts had only one player on their Wednesday injury report: running back Tyler Goodson (elbow), and he was limited. 

Las Vegas Raiders at New England Patriots (-2.5)

To be announced.

Arizona Cardinals (-6.5) at New Orleans Saints 

Only two Arizona Cardinals popped up on the Wednesday injury report: guard Will Hernandez (knee, limited) and guard Jon Gaines II (thumb, fully practiced). 

New Orleans Saints offensive lineman Trevor Penning (toe) was the only player not to practice and just four others were limited: Chase Young (calf), cornerback Alontae Taylor (groin), defensive back Jordan Howden (oblique) and defensive tackle Khristian Boyd (hand). 

Pittsburgh Steelers (-2.5) at New York Jets 

Only two Pittsburgh Steelers popped up on the injury report on Wednesday: linebacker Nick Herbig (hamstring) and rookie first-round pick defensive tackle Derrick Harmon (knee). 

The New York Jets may have lost guard Alijah Vera-Tucker (triceps) for the season with a torn triceps. Offensive tackle Chukwuma Okorafor (hand) also didn't practice on Wednesday. All-Pro cornerback Sauce Gardner (fibula) and quarterback Tyrod Taylor (knee) were both limited. 

New York Giants at Washington Commanders (-6)

Left tackle Andrew Thomas (foot, limited)) was the only New York Giant on the team's Wednesday injury report. 

Tight end Zach Ertz (rest) was the only Washington Commander to not practice on Wednesday while edge rusher Dorance Armstrong (knee), wide receiver Noah Brown (knee) and cornerback Jonathan Jones (hamstring) were limited. 

Carolina Panthers at Jacksonville Jaguars (-3.5)

Only four players are on the Carolina Panthers' initial injury report: offensive tackle Ikem Ekwonu (illness, did not practice), guard Damien Lewis (shoulder/ankle, limited), guard Robert Hunt (foot, limited) and cornerback Damarri Mathis (knee, limited).

The Jacksonville Jaguars' injury report was even lighter with just three players: offensive tackle Wyatt Milum (knee, did not practice), cornerback Montaric Brown (ankle, did not practice)  and guard Cole Van Lanen (shoulder, limited). 

Tennessee Titans at Denver Broncos (-8.5)

The Tennessee Titans only had three players on their injury report: left tackle Dan Moore Jr. (ankle, did not practice), cornerback L'Jarius Sneed (knee, limited) and safety Kevin Winston Jr. (hamstring, limited). 

The Denver Broncos only had two players who didn't fully practice on Wednesday: tight end Nate Adkins (ankle, did not practice) and linebacker Dre Greenlaw (quad, did not practice).

San Francisco 49ers (-2.5) at Seattle Seahawks

 To be announced.

Houston Texans at Los Angeles Rams (-3)

To be announced. 

Baltimore Ravens (-1) at Buffalo Bills 

The Baltimore Ravens begin the week with just four players on the injury report: cornerback Jaire Alexander (knee, limited), guard Daniel Faalele (illness, limited), tight end Isaiah Likely (foot, did not practice) and fullback Patrick Ricard (calf, did not practice). 

The Buffalo Bills only had four players who didn't practice fully on Wednesday: cornerback Tre'Davious White (groin, did not practice), cornerback Christian Benford (groin, limited), defensive tackle DeWayne Carter (Achilles, did not practice) and kicker Tyler  Bass (left hip/groin, limited). 

Minnesota Vikings (-1.5) at Chicago Bears

To be announced.