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Week 2 of 2025 NFL season kicked off on Thursday in Green Bay, and the action really gets going on Sunday with 13 games on the schedule ahead of a two-game Monday Night Football slate. We wish stars and other notable players would be healthy all year long, but that's rarely the case, even this early in the season. Ahead of Week 2, we saw plenty of big names on the injury report ahead of Sunday, and if you're interested in NFL betting, you need to be aware of who's in and who's out before you place any wagers at top sportsbooks. 

Here, we break down the biggest NFL injuries to know ahead of 15 games on Sunday and Monday, including how lines have shifted according to the latest SportsLine consensus odds, which uses the latest data and odds from top sportsbooks. We've also updated games with final injury designations ahead of their kickoffs as that information has been made available.

New York Giants vs Dallas Cowboys (1 p.m. ET)

The Cowboys really can't seem to catch a break with their cornerback duo of DaRon Bland and Trevon Diggs, as it seems like the team always has one or the other. That's the case Sunday, too, with Bland ruled out with a foot injury. 

On the other side, the Giants are without left tackle Andrew Thomas for the second week in a row. The good news is receiver Wan'Dale Robinson was questionable but will suit up against a depleted Dallas secondary.

Things have stayed pretty steady as far as the betting lines for this matchup, with the only major change being a slight bump for Dallas on the spread from -4.5 to -5.5.

Seattle Seahawks vs Pittsburgh Steelers (1 p.m. ET)

Both teams will likely be without top players in the secondary for this matchup. The Steelers won't have top cornerback Joey Porter Jr. or starting safety DeShon Elliott, while Seattle is without Devon Witherspoon, who plays outside and nickel. Rookie safety Nick Emmanwori is out for the Seahawks after getting hurt making a tackle early in the first quarter of his NFL debut. Rookie defensive tackle Derrick Harmon will miss his second straight game for the Steelers after injuring his knee in the preseason.

The Steelers had a much better offensive showing last week than expected with Aaron Rodgers throwing four touchdown passes, while Seattle scored only 13 points against San Francisco. 

The Steelers are now favored at -3.5 after opening at -1.5, and the over/under has gone to 40.5 after being 43.5 at open.

Los Angeles Rams vs Tennessee Titans (1 p.m. ET)

Two 2024 draft picks won't play for the Titans on Sunday with offensive tackle JC Latham and defensive tackle T'Vondre Sweat each ruled out. Those are big losses for Tennessee with Los Angeles having a great pash rush on defense and aiming to run the ball on offense, something Sweat is tasked with stopping as a massive nose tackle. Starting Rams guard Steve Avila is out for this matchup as well.

The total for this one has dipped dramatically from 46.5 at open to 40.5 on Sunday. Neither side looked particularly great on offense last week, though each went up against good defenses with the Rams beating the Texans and the Titans falling to the Broncos.

Buffalo Bills vs New York Jets (1 p.m. ET)

The Bills' defense is banged up after allowing 40 points to Baltimore in Week 1. Top defensive tackle Ed Oliver won't play against the Jets, and the same is the case for nickel corner Taron Johnson. The good news is after missing Week 1, starting cornerback Tre'Davious White will suit up for Buffalo. New York just scored 32 points in a losing effort to the Steelers in Week 1, and Justin Fields and Co. may be in line for another big game as the Bills deal with injuries on defense.

The Bills opened as 8.5-point favorites and now sit at -6.5, and the total is up to 47.5 on Sunday after starting at 44.5.

New England Patriots vs Miami Dolphins (1 p.m. ET)

The Dolphins will be without Darren Waller for the second week in a row as the once-retired tight end is dealing with a hip injury. The team will also be without a starting offensive tackle in Austin Jackson. Second-year running back Jaylen Wright, the team's No. 2 back, is also out for the second week in a row. Rookie Ollie Gordon is once again the top backup to lead back De'Von Achane. 

On the other side, the Patriots will be without their top defender and arguably top player on the entire roster as cornerback Christian Gonzalez is set to miss his second straight game with a hamstring injury, welcome news for Miami receivers Tyreek Hill and Jayden Waddle. 

The total is down to 43.5 from 45.5 at open.

Jacksonville Jaguars vs Cincinnati Bengals (1 p.m. ET)

  • No notable injuries to note

The Bengals have no one listed on their final injury report of the week while the only two Jaguars with designations are a backup rookie offensive lineman and a backup cornerback. The Bengals are looking for a better offensive output after struggling mightily against the Browns in a 17-16 win last week, while the Jags are looking to build off a 26-10 win over Carolina. 

The Bengals are favored at 3.5 after opening at -5.5.

San Francisco 49ers vs New Orleans Saints (1 p.m. ET)

The 49ers are either a healthy juggernaut or are as beat up as any team in the NFL. Right now, they're the latter. San Francisco won its Week 1 contest 17-13 in Seattle, but the 9ers now are without quarterback Brock Purdy for potentially five weeks as well as tight end George Kittle for the foreseeable future. Former first-round pick Mac Jones will now get the start in New Orleans at quarterback for San Francisco.

The good news for the 49ers is Jones will have receiver Jauan Jennings to throw to as the veteran receiver has been battling a shoulder injury. Additionally, star left tackle Trent Williams will also suit up against the Saints. Both Jennings and Williams were questionable on Friday.

The Saints will be without both guard Trevor Penning and defensive end Chase Young for the second week in a row, and top safety Julian Blackmon is also out due to a shoulder injury.

Due to injuries on the 49ers' side, the spread has gone from -7 to -3 for San Francisco, and the total is 40.5 after opening at 44.5.

Chicago Bears vs Detroit Lions (1 p.m. ET)

These two NFC North foes will look to get their first win of the year on Sunday when they face off in Detroit. The Lions listed two notable starters as questionable in left tackle Taylor Decker and safety Kirby Joseph, but both are active for Week 2. 

As for the Bears, do-it-all defensive back Kyler Gordon is out for the second week in a row. They will have veteran defensive tackle Grady Jarrett, who was questionable. That's good news for Chicago as Detroit loves to run the football.

The Lions are 6.5-point favorites after opening at -4.5, while the total has dropped from 48.5 to 46 as of Sunday morning.

Cleveland Browns vs Baltimore Ravens (1 p.m. ET)

The Ravens will again be without two versatile players on offense with tight end Isaiah Likely and Patrick Ricard each ruled out for the second week in a row. Baltimore score 40 points in the opener against Buffalo without those two in the lineup, however. 

As for the Browns, rookie running back Quinshon Judkins will play in Week 2. Judkins was questionable to play as he was the last 2025 draft pick in the NFL to sign his rookie deal. This stemmed from domestic abuse allegations, which caused the rookie to not sign his contract and to miss most of the offseason. He will dress on Sunday, and it's unclear how much he'll play in tandem with Jerome Ford and fellow rookie Dylan Sampson this week.

The total has gone up a hair from 44.5 to 45.5 as of Sunday.

Denver Broncos vs Indianapolis Colts (4:05 p.m. ET)

The Colts are without two top cornerbacks this week as starter Charvarius Ward and backup Jaylon Jones won't play against the Broncos. Denver is looking for a better offensive output after a rough start against the Titans in which second-year quarterback Bo Nix threw two interceptions. He'll have a better matchup this week against a depleted Colts cornerback group.

Denver opened at -3.5 on the road, but that's dropped to -1.5. The over/under has also dropped a point from 44.5 to 43.5.

Carolina Panthers vs Arizona Cardinals (4:05 p.m. ET)

  • CAR OT Ikem Ekownu (illness, will play)
  • AZ OG Will Hernandez (knee, out)

The two most notable injuries ahead of this matchup were on the offensive line. Carolina left tackle Ikem Ekwonu will make his season debut after being questionable, while Arizona guard Will Hernandez is out for the second week in a row.. Ekwonu missed Week 1 after appendectomy surgery. 

Oddsmakers have had this one trending in Arizona's favor as the Cards are now -6.5 after opening at -4.5 at home. The total is also down to 44.5 after opening at 46.5.

Philadelphia Eagles vs Kansas City Chiefs (4:25 p.m. ET)

The Chiefs were already without Rashee Rice due to a suspension when Xavier Worthy suffered a shoulder injury after colliding with Travis Kelce in Brazil last week. Worthy is out for Week 2, which will put more of an emphasis on JuJu Smith-Schuster, Hollywood Brown and Kelce in the passing game, especially with rookie receiver Jalen Royals out for the second week in a row.

On the other side, Philadelphia will be without top tight end Dallas Goedert due to a knee injury. He paced Philadelphia with seven catches last year and was second in yards with 44. 

After getting beaten in Week 1, the Chiefs are no longer favored at home as the line has shifted from Eagles +1.5 to Eagles -1.5. The total has also gone up from 45.5 to 47.

Atlanta Falcons vs Minnesota Vikings (8:15 p.m. ET)

Minnesota's going to be without some big names for this contest, with do-it-all linebacker/edge rusher Andrew Van Ginkel out with a concussion and inside linebacker Blake Cashman on injured reserve with a hamstring injury. J.J. McCarthy will also be without left tackle Christian Darrisaw due to a knee injury. 

The Falcons were without one of their top pass catchers last week in Darnell Mooney, who has been nursing a shoulder injury, and top receiver Drake London suffered a shoulder injury of his own in Week 1. The good news for Atlanta is Michael Penix Jr. will have his two top receivers for Sunday Night Football against the Vikings. 

After opening as 5.5-point favorites, the Vikings are now 3.5-point favorites while the total moved down from 45.5 to 44.5.

Tampa Bay Buccaneers vs Houston Texans (7 p.m. ET, Monday)

Christian Kirk joined the Texans this offseason to be a No. 2 receiver behind Nico Collins, but he didn't play last week due to a hamstring injury. He didn't practice this week and is out for Week 2. 

Two of Tampa's top players missed last week, though that was expected. Receiver Chris Godwin and left tackle Tristan Wirfs sat out the Bucs' win over Atlanta, and despite both logging limited participation earlier this week, they were both ruled out for Monday. 

The total for this game has dipped from 46.5 to 42.5 on the heels of the Texans scoring only nine points in Week 1, but the spread has moved in Houston's favor to -2.5 after opening at -1.5. 

Los Angeles Chargers vs Las Vegas Raiders (10 p.m. ET, Monday)

The big injury news to follow here is star Raiders tight end Brock Bowers, who left Week 1 with a knee injury. While head coach Pete Carroll said Bowers could have returned to action last Sunday, his participation, or lack thereof, in practice this week signals another story. This would be a big blow for Vegas against a Chargers defense that was among the league's best last year. Bowers is officially questionable for Monday, though Carroll said he expects his star tight end to play. If Bowers cant go, the Raiders have a very capable No. 2 tight end in former second-round pick Michael Mayer, who had four catches last week.

The Chargers are now -3.5 after opening at -2.5, and the total is up to 46.5 from 43.5.