-
Nico Hoerner 2B | CHC
Cubs' Nico Hoerner: Hits leadoff home run Wednesday
Hoerner went 3-for-5 with a double, a solo home run, an additional run scored and two total RBI in Wednesday's 6-2 win over the Rays.
Hoerner has been hot to start the season, and for the second straight day, the Cubs rewarded the speedy infielder by batting him leadoff. It was also the second straight game that he batted first despite facing a righty starter, bumping Michael Busch down in the order. Hoerner responded Wednesday with a leadoff home run, which was his first long ball of the year. As long as Hoerner stays locked in at the plate, he figures to stick as Chicago's leadoff hitter against both righties and lefties for the foreseeable future.
-
Yairo Padilla SS | STL
Cardinals' Yairo Padilla: Sidelined at Single-A
Single-A Palm Beach placed Padilla on the 7-day injured list with a shoulder strain, Sam Dykstra of MLB Pipeline reports.
Padilla has consistently been around 20 percent better than league average while stealing 46 bases in 73 games at the rookie level across his age-17 and age-18 seasons. The switch hitter won't turn 19 until around midseason and has hit only one home run in pro ball, but if he grows into even fringe-average power, the rest of his tools (above-average hit, speed, defense) could carry him to an everyday shortstop role in time.
-
Geraldo Perdomo SS | ARI
Diamondbacks' Geraldo Perdomo: Ends drought
Perdomo went 1-for-2 with two walks, an RBI and a stolen base in Wednesday's 7-2 win over the Mets.
Perdomo's first-inning single snapped an 0-for-13 run. Following a breakout in 2025 when he had 20 home runs and 100 RBI, Perdomo's scuffled to open this season. He's slashing .179/.277/.308 with four RBI through 12 games; at this point last season, the shortstop slashed .293/.347/.415 with 12 RBI.
-
Yordany De Los Santos SS | PIT
Pirates' Yordany De Los Santos: To 7-day IL
High-A Greensboro placed De Los Santos on the 7-day injured list April 4 with an undisclosed injury.
The 21-year-old infielder hit .375 with a home run and two steals in two games prior to suffering the injury. De Los Santos logged a .699 OPS in 116 games at Single-A in 2025.
-
Dustin Harris LF | SD
White Sox's Dustin Harris: Swipes two bags in first start
Harris went 1-for-3 with a walk, a run scored, an RBI and two stolen bases in Wednesday's 5-3 loss to the Orioles.
Making his first start since being recalled from Triple-A Charlotte on Monday, Harris made an immediate impact with his legs -- not a big surprise for a player who went 34-for-39 on steal attempts over 110 games between Triple-A and the majors for the Rangers last season. The 26-year-old outfielder never really got a chance to show what he could do with Texas, but his career .276/.366/.417 slash line over more than 1,300 plate appearances at the top level of the minors suggests he may be able to contribute for Chicago at the plate as well. Harris could see consistent playing time in the short term while Austin Hays (hamstring) and Everson Pereira (ankle) are on the IL.
-
Sean Burke SP | CHW
White Sox's Sean Burke: Settles for no-decision Wednesday
Burke didn't factor into the decision in Wednesday's 5-3 loss to the Orioles, allowing two runs on two hits and two walks over five innings. He struck out three.
It was the second straight solid performance from the right-hander, who tossed 58 of 92 pitches for strikes and left the mound with a 3-2 lead before watching the White Sox bullpen cough it up in the top of the sixth. Burke is still looking for his first win of 2026, but he'll take a 3.60 ERA, 1.07 WHIP and sparkling 15:3 K:BB through 15 innings over three outings (two starts) into his next trip to the mound, which is set to come at home early next week against the Rays.
-
J.D. Thompson SP | MIL
Brewers' J.D. Thompson: Pro debut delayed
Thompson has not been assigned to a minor-league affiliate as he recovers from a hamstring strain, Sam Dykstra of MLB Pipeline reports.
He suffered the injury in spring training and should join High-A Wisconsin around the start of May. Thompson was a polished left-handed starter in the SEC, and there's a chance the Brewers might be able to improve his stuff with pro instruction.
-
Zach Eflin SP | BAL
Orioles' Zach Eflin: Undergoes TJ surgery
Eflin underwent Tommy John surgery on his right elbow Wednesday, Andy Kostka of TheBaltimoreBanner.com reports.
The Orioles moved Eflin to the 60-day injured list Tuesday after he received a second opinion on his injured elbow, and he'll now be out until midway through the 2027 campaign after going under the knife. The 32-year-old righty has made just 15 starts over the past two seasons, during which he's posted a 5.76 ERA and 1.43 WHIP over 75 innings.
-
Taylor Ward RF | SEA
Orioles' Taylor Ward: Trio of two-baggers in win
Ward went 4-for-5 with three doubles, a run scored and two RBI in Wednesday's 5-3 win over the White Sox.
The veteran outfielder is still looking for his first homer as a member of the Orioles, but he's been doing plenty of damage nonetheless. Through 12 games to begin the season, Ward is slashing .383/.464/.574 with an astounding nine doubles, five runs and eight RBI with an 8:11 BB:K.
-
Miles Mikolas RP | WAS
Nationals' Miles Mikolas: Losing ways continue
Mikolas (0-3) took the loss Wednesday against the Cardinals, allowing two runs on five hits and three walks in three innings. He struck out three.
Facing his former club, Mikolas didn't last very long to add to his woes in the early going. The veteran right-hander had coughed up a staggering 15 runs across his first 9.1 innings prior to Wednesday, and the Nationals decided that they'd seen enough following just 55 pitches from Mikolas on Wednesday. A relatively manageable assignment against the Pirates awaits Mikolas for his next start, but his 12.41 ERA, 2.35 WHIP and 11:7 K:BB make him a fantasy option to avoid until he gains some form of traction.