Pena is out of the lineup for Wednesday's game against the Red Sox.

Pena continues to play every other day as the Astros ease him back into action following a recovery from a fractured finger. He should be ready to resume playing on an everyday basis soon, but it's unclear when exactly it will happen. Carlos Correa will start at shortstop and Isaac Paredes will cover third base Wednesday as the Astros go for the series sweep.

Smith is out of the lineup for Wednesday's game against the Orioles.

Smith was part of the lineup against a lefty (the Phillies' Cristopher Sanchez) on Opening Day, but the left-handed-hitting infielder will hit the bench for a second straight matchup versus a southpaw. Ezequiel Duran will get the nod at second base Wednesday against Trevor Rogers and could serve as a regular platoon partner for Smith.

Higashioka is out of the lineup for Wednesday's game against the Orioles.

Through Texas' first six games, Higashioka has drawn two starts at catcher to Danny Jansen's four. The Rangers could split the reps fairly equitably between the two backstops this season, but at least in the early going, Jansen looks to be Option 1A of the duo.

Acuna will start at shortstop and bat ninth in Wednesday's contest versus the Marlins.

It's the third start at shortstop already this season for Acuna, who has also made two starts in center field. Colson Montgomery is at third base for the White Sox on Wednesday. The 24-year-old Acuna is currently eligible only at second base on most fantasy platforms, but he's on track to pick up eligibility at shortstop and outfield soon. Acuna is 2-for-12 with a 1:1 BB:K and two stolen bases in his first four games this season.

Hays is absent from the lineup for Wednesday's contest in Miami.

Hays will receive a day off after going 3-for-19 with a 0:9 BB:K over his first 19 plate appearances this season. Andrew Benintendi will patrol left field for the White Sox on Wednesday and Miguel Vargas will get a start at designated hitter.

Quero is absent from the lineup for Wednesday's game in Miami.

It's a day game after a night game, so Quero will get a breather after starting at catcher the previous three days. Reese McGuire will be behind the dish and bat eighth in Wednesday's series finale.

Bowden (lat) struck out a batter and allowed one earned run on three hits over an inning of relief Monday in Triple-A Las Vegas' 13-8 loss to Oklahoma City.

After closing out the 2025 season on the Athletics' injured list while recovering from a left lat strain, Bowden re-signed with the franchise on a minor-league deal over the winter but didn't end up appearing in any games during the Cactus League. However, the veteran southpaw was evidently healthy enough to avoid a stint on Las Vegas' injured list to begin the season. He should serve as a key reliever for the Triple-A club while he awaits a potential call-up to the big-league bullpen.

Hernaiz will start at second base and bat eighth in Wednesday's game against Atlanta.

Hernaiz will draw his second start of the season, both of which have come against left-handed pitchers. The 24-year-old appears poised to serve as an occasional platoon partner at second base with the left-handed-hitting Jeff McNeil, who will hit the bench for a second straight matchup versus a southpaw (Chris Sale).

The White Sox designated Paez for assignment Wednesday.

Chicago will replace Paez on the 40-man roster and in the bullpen with right-hander Lucas Sims, who was called up from Triple-A Charlotte. Since Paez was a Rule 5 Draft selection over the winter, the White Sox will have to offer him back to the Red Sox if he goes unclaimed off waivers. The 22-year-old righty made relief appearances in three of the White Sox's first five games, allowing six earned runs on four hits and three walks while striking out two batters over three innings.

The Orioles selected Suarez's contract from Triple-A Norfolk on Wednesday.

Suarez joins the active roster as a replacement for Zach Eflin (elbow), who was placed on the 15-day injured list. The 36-year-old Suarez will provide some length out of the Orioles bullpen.