Pena (finger) could be ready to play in back-to-back games this weekend, Brian McTaggart of MLB.com reports.

Pena managed to avoid an injured list stint but has started every other game so far this season as the Astros ease him back into action following a fractured right ring finger. The 28-year-old is out of the lineup for Wednesday's game against the Red Sox and the Astros are idle Thursday, so he could be ready to play back-to-back contests as soon as Friday and Saturday against the Athletics.

Barger is out of the lineup for Wednesday's game against the Rockies.

After sitting against right-handed starter Ryan Feltner on Tuesday, the left-handed-hitting Barger will remain on the bench for the series finale while southpaw Kyle Freeland takes the hill for Colorado. Jesus Sanchez will spell Barger in right field and will bat seventh.

Jackson will start at second base and bat ninth in Wednesday's game against the Rangers.

Occupying second base for the fourth time in five games, Jackson appears to have the early edge in playing time at the position over Blaze Alexander. However, with just three hits and a 0:6 BB:K through 12 plate appearances, Jackson hasn't run away with the job. Both Jackson and Alexander will see their opportunities at the keystone dwindle once Jackson Holliday (hand) returns from the injured list, likely at some point around the middle of the month.

Pena is out of the lineup for Wednesday's game against the Red Sox.

Pena continues to play every other day as the Astros ease him back into action following a recovery from a fractured finger. He should be ready to resume playing on an everyday basis soon, but it's unclear when exactly it will happen. Carlos Correa will start at shortstop and Isaac Paredes will cover third base Wednesday as the Astros go for the series sweep.

Smith is out of the lineup for Wednesday's game against the Orioles.

Smith was part of the lineup against a lefty (the Phillies' Cristopher Sanchez) on Opening Day, but the left-handed-hitting infielder will hit the bench for a second straight matchup versus a southpaw. Ezequiel Duran will get the nod at second base Wednesday against Trevor Rogers and could serve as a regular platoon partner for Smith.

Hernaiz will start at second base and bat eighth in Wednesday's game against Atlanta.

Hernaiz will draw his second start of the season, both of which have come against left-handed pitchers. The 24-year-old appears poised to serve as an occasional platoon partner at second base with the left-handed-hitting Jeff McNeil, who will hit the bench for a second straight matchup versus a southpaw (Chris Sale).

Seager went 2-for-4 with a walk, a home run and two RBI in Tuesday's 8-5 win over Baltimore.

Seager clubbed his second homer of the season, a solo shot in the ninth inning. The multi-hit effort was the third in five starts for Seager, who is 6-for-18 with four RBI to open the season. The early production is an encouraging sign for the shortstop, who was limited to 102 games in 2025.

Duran started at third base and went 1-for-4 with a solo home run in Tuesday's 8-5 win over the Orioles.

Duran put the Rangers up early with a solo shot in the third inning. He filled in for the struggling Josh Jung, who is 0-for-17 to start the season. The versatile Duran has started twice this season -- the other start coming at second base -- and contributed an extra-base hit and RBI in each contest.

Crawford (shoulder) went 0-for-4 with a walk in his first rehab game with Triple-A Tacoma on Tuesday.

Crawford played all nine innings at shortstop in his first game action in three weeks. The veteran infielder's rehab assignment happened to kick off on the same day the Mariners announced a contract extension with top shortstop prospect Colt Emerson, who played third base for the Rainiers next to Crawford on Tuesday. Emerson is expected to remain at Tacoma for now and Crawford could be activated at any time, but the former could eventually push aside the latter when he's ready to take over at shortstop with the big club.

Grissom (wrist) went 1-for-3 with a single in his first rehab game with Triple-A Salt Lake on Tuesday.

Grissom was declared ready for game action as he works his way back from a sprained left wrist. The infielder is eligible for activation from the 10-day injured list and could be ready to go Friday when the Angels open up their first homestand of the season. Once activated, Grissom will be in the mix for playing time at second and third base for the Halos.