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Joe Ryan SP | MIN
Twins' Joe Ryan: Fans nine in loss
Ryan (5-4) took the loss Wednesday against the Dodgers, allowing four runs on eight hits and one walk while striking out nine over six innings.
Ryan's outing got off to a rough start when Mookie Betts led off the second inning with a solo homer, and Los Angeles added three more runs in the third to build what proved to be the decisive lead. Despite the loss, the right-hander's stuff remained electric, as he matched his season high with nine strikeouts and generated 17 swinging strikes. Ryan has now completed at least six innings in eight of his last nine starts. He'll carry a 3.18 ERA, 1.03 WHIP and 108:19 K:BB across 93.1 innings into his next scheduled start on the road against Houston.
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Carmen Mlodzinski RP | PIT
Pirates' Carmen Mlodzinski: Earns second save
Mlodzinski threw three scoreless innings with three strikeouts while allowing two hits and no walks to earn the save Wednesday against the Mariners.
Mlodzinski continues to serve in a bulk-relief role, this time following Braxton Ashcraft while finishing off a blowout win for the Pirates. He earned his second save in the process and has not been charged with an earned run in each of his last three appearances. However, Mlodzinski's fantasy relevance remains limited because he's pitching about once a week on a starter's schedule, yet with lesser volume and win potential.
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Gage Jump SP | ATH
Athletics' Gage Jump: Continues to impress
Jump allowed three hits and a walk while striking out nine over five scoreless innings in a no-decision versus the Giants on Wednesday.
Jump's nine strikeouts reset his season high for the third start in a row. He's also kept runs off the board in three of his six career starts so far. The 23-year-old now has a 2.04 ERA, 0.96 WHIP and 35:10 K:BB across 35.1 innings. He's also yet to allow a home run, which is particularly useful in a hitter-friendly home park. Jump's next projected start will be the biggest test of his young career, as he is lined up for a home start against the Dodgers.
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Tyler Mahle SP | ATL
Giants' Tyler Mahle: Strong showing in return
Mahle allowed two hits and two walks while striking out four over 5.2 scoreless innings in a no-decision versus the Athletics on Wednesday.
Mahle missed about four weeks due to a hamstring strain. He was pretty good in his return, throwing 44 of 70 pitches for strikes, but the Giants didn't get on the board until the ninth inning, leaving him with a no-decision. On the year, Mahle has a 5.49 ERA, 1.46 WHIP and 61:26 K:BB over 62.1 innings across 12 starts. The veteran right-hander's time off while injured could help him reset after his poor form to begin the campaign. He is lined up to make his next start on the road in Arizona.
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Martin Perez SP | ATL
Braves' Martin Perez: Chased in fifth inning
Perez (6-4) allowed three runs on four hits and four walks while striking out four over four-plus innings to take the loss Wednesday versus San Diego.
Perez didn't have his best command Wednesday, throwing just 42 of 82 pitches for strikes. James Karinchak allowed an inherited runner to score after Perez put the first two batters aboard in the fifth inning, and that run ended up being the difference in the game. Perez is now at a 3.00 ERA, 1.13 WHIP and 60:27 K:BB through 72 innings over 16 games (12 starts) this season. The veteran left-hander has yet to allow more than four runs in a game this year, making him a reliable starter more often than not. Perez is projected to make his next start at home versus the Cardinals.
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David Peterson SP | CHC
Cubs' David Peterson: Dealt to Cubs
The Cubs acquired Peterson from the Mets on Wednesday in exchange for infielder Cole Mathis (undisclosed), Jeff Passan of ESPN.com reports.
Peterson had endured a rough season with the Mets, turning in a 6.09 ERA and 1.65 WHIP in 68 innings across 16 appearances (eight starts). However, the Cubs will gladly take all the rotation arms they can get at this point, as Edward Cabrera (hamstring) and Ben Brown (neck) became the fifth and sixth Chicago starting pitchers to land on the injured list Wednesday. Peterson is expected to provide immediate aid to the rotation and could make his first start with the Cubs as soon as Friday at Milwaukee, after he threw 79 pitches Sunday in his final appearance with the Mets.
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JP Sears SP | SD
Padres' JP Sears: Wins in season debut
Sears (1-0) allowed two runs on five hits and two walks while striking out five over 5.2 innings to earn the win over Atlanta on Wednesday.
This was Sears' first outing at the major-league level after his poor spring training numbers cost him a shot at the Opening Day roster. He pitched fairly well Wednesday, throwing 53 of 81 pitches for strikes while coming up an out short of a quality start. He had a 7.92 ERA, 1.84 WHIP and 62:28 K:BB over 63.2 innings across 14 starts for Triple-A El Paso, but a pitcher-friendly home park in the majors should help Sears perform better than he did while on the hitter-friendly circuit in the minors. Sears struggled a bit in 2025 with a 5.04 ERA, 1.32 WHIP and 117:36 K:BB across 135.2 innings between the Athletics and the Padres. While Lucas Giolito (elbow) and German Marquez (forearm) are both out, Sears should have a chance to stay in a starting role. Even if Marquez is back soon, Sears could edge out Griffin Canning for the last spot in the rotation to begin next week when the Padres visit the Cubs for a three-game series.
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Ryan Weathers SP | NYY
Yankees' Ryan Weathers: Fans six in quality start
Weathers (3-5) notched the win Wednesday against the Yankees, allowing two runs (one earned) on six hits and two walks in six innings. He struck out six.
Weathers outdueled Tigers southpaw Tarik Skubal on Wednesday, keeping the ball in the park on a night where Skubal was taken yard three times. That also makes it back-to-back quality starts for Weathers, which is an encouraging sign after the southpaw gave up 16 runs across his previous three outings. Weather has a respectable 3.95 ERA, 1.14 WHIP and 95:24 K:BB over 86.2 innings, and he's set to get another crack at Detroit at home in his next appearance.
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Matthew Liberatore SP | STL
Cardinals' Matthew Liberatore: Unravels in fourth inning
Liberatore (3-5) allowed six runs on eight hits and two walks while striking out three over 5.1 innings to take the loss versus the Diamondbacks on Wednesday.
Liberatore got through three innings with little trouble, but Arizona piled on six runs in the fourth. He allowed back-to-back home runs to LuJames Groover and Ketel Marte to cap that rally. Liberatore's decent start to the year has fallen apart in June -- he's allowed 22 runs (18 earned) across 15.2 innings over his four starts this month. He's now at a 5.56 ERA, 1.58 WHIP and 70:29 K:BB in 77.2 innings through 16 starts overall. The southpaw is tentatively projected to make his next start at Atlanta, which is not a matchup that offers much bounce-back potential.
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Tarik Skubal SP | LAD
Tigers' Tarik Skubal: Stung by long ball in loss
Skubal (3-4) took the loss Wednesday against the Yankees, allowing four runs on four hits and no walks in six innings. He struck out nine.
The Yankees made the most out of their hits, taking Skubal deep three times Wednesday. The All-Star left-hander served up a trio of home runs for the sixth time in his career, and he's now given up six homers in his last three starts since coming off the injured list after surrendering only two in his first seven outings of 2026. Skubal will be trying to right the ship when he brings a 3.32 ERA, 0.99 WHIP and 66:8 K:BB over 59.2 innings into a scheduled rematch with the Yankees next week in New York.