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Quarterback injuries throw everything for a loop in the NFL, and that's certainly been the case in the early stages of 2025. That remains the case for Week 6, but signal-callers aren't the only big injuries worth monitoring this weekend. If you're interested in NFL betting, you need to be aware of who's in and who's out before you place any Week 6 bets of your own.

Here, we break down the biggest NFL injuries to know for all of the Week 6 games on Sunday and Monday, including where lines currently stand, according to the latest SportsLine consensus odds, which uses the latest data and odds from top sportsbooks. This post will be updated as official inactives lists are announced before kickoff. 

Denver Broncos vs. New York Jets (9:30 a.m. ET, in London)

  • No notable injuries

The Broncos have stayed largely healthy in the early stages of 2025, and the Jets have really just dealt with Justin Fields' concussion, which is a thing of the past. These two AFC foes meet in London as the NFL is in Europe for the third week in a row, and Denver is a 7.5-point favorite, according to SportsLine consensus odds, while the total is 43.5.

Seattle Seahawks at Jacksonville Jaguars (1 p.m. ET)

A Seahawks defense that started the year out well but faltered due to injuries last week will again be tested with notable absences. Edge rusher Derick Hall is out, as are three of Seattle's five starting defensive backs -- Devon Witherspoon, Julian Love and Riq Woolen.

The Seahawks are slight favorites on the road at -1.5, and the total is 47.5.

Los Angeles Chargers at Miami Dolphins (1 p.m. ET)

The Chargers lost their top left tackle before the season, and 2024 rookie standout Joe Alt has been banged up this year and will miss Week 6 with an ankle injury. The Chargers are looking to get back in the win column after consecutive losses, and they will be without receiver Quentin Johnston, who is in the midst of a breakout 2025 with 377 yards and four touchdown receptions. He was initially listed as questionable. 

Los Angeles is a 3.5-point favorite on Sunday with the total set at 44.5.

Los Angeles Rams at Baltimore Ravens (1 p.m. ET)

The Ravens will again be without star quarterback Lamar Jackson as the speedy signal-caller is sidelined with a hamstring injury he suffered two weeks ago. The good news is top receiver Zay Flowers will play after being questionable, which is good news for Cooper Rush, who will start at quarterback again for Baltimore. The Ravens are 1-4 and face one of the top NFC teams in the Rams, who enter Week 6 relatively healthy.

The Rams are 7-point favorites on the road against the beat-up Ravens, and the total is 43.5. 

Arizona Cardinals at Indianapolis Colts (1 p.m. ET)

The scuffling Cardinals will not have their quarterback as Kyler Murray is officially inactive for Sunday with a foot injury. With Murray out, veteran Jacoby Brissett will start for Arizona. 

The red-hot Colts are now 8.5-point favorites at home here, with the total sitting at 46.5.

Dallas Cowboys at Carolina Panthers (1 p.m. ET)

The Cowboys will have to wait at least one more week for CeeDee Lamb to return as the star receiver is once again out with an ankle injury. That's a tough blow for Dallas, especially as Carolina has had one of the NFL's worst defenses since the start of 2024. And speaking of defenses, cornerbacks DaRon Bland and Trevon Diggs are active after being listed as questionable.

The Panthers will be without starting running back Chuba Hubbard for the second week in a row when they face a porous Cowboys defense on Sunday. The good news for Carolina is Hubbard's backup, Rico Dowdle, was up to the task last week with 206 rushing yards and a touchdown against Miami, and he faces his former team this time around.

Dallas is a 3-point favorite at Carolina, and the total is 47.5.

New England Patriots at New Orleans Saints (1 p.m. ET)

The Saints' offense can breathe a sigh of relief as Alvin Kamara, who was listed as questionable, will suit up against the Patriots. Kamara has 283 rushing yards and is also a key part of the passing game with 17 receptions.

The Patriots have tried a few hands at running back to begin the year, especially with Rhamondre Stevenson's fumbling issues, but Antonio Gibson, who saw an uptick in snaps of late, is out for the year with a knee injury. Stevenson and rookie TreVeyon Henderson will likely split touches once again moving forward. On defense, New England's top player, cornerback Christian Gonzalez, continues to have an injury-filled 2025, but he's active for Sunday after being listed as questionable over the weekend.

New England is a 3.5-point favorite on the road, and the total is 46.

Cleveland Browns at Pittsburgh Steelers (1 p.m. ET)

The Steelers will have star cornerback Jalen Ramsey for this matchup with Cleveland after he was listed as questionable for this matchup, which is not good news for the Browns and rookie quarterback Dillon Gabriel. Pittsburgh also gets Jaylen Warren, back this week. Warren was the team's lead back in the early stages of the year, and is off the injury report after missing the Steelers' win over the Vikings in London two weeks ago.

Pittsburgh is favored by 6 points and the total is 38.5.

Tennessee Titans at Las Vegas Raiders (4:05 p.m. ET)

The Raiders have lost four in a row, so perhaps a date with the 1-4 Titans is just what Pete Carroll's team needs here. They'll have to do without star tight end Brock Bowers, who is out for the second week in a row. What should help Geno Smith and the Raiders' passing attack is tight end Michael Mayer, who was also out last week, is active.

The Raiders are favored by 4.5 points here, with the total sitting at 41.5.

San Francisco 49ers at Tampa Bay Buccaneers (4:25 p.m. ET)

It's very likely another week of the Mac Jones Show as Brock Purdy is out once again with a toe injury. The 49ers starter has played just twice this year, while Jones has gone 3-0 filling in for the Pro Bowler. Jones will start, though it's worth noting he was questionable due to two different injuries. 2024 first-round pick Ricky Pearsall is out with a knee injury in the passing game.

The Bucs just dropped 38 points on Seattle, but the offense remains fairly beat up. In addition to Mike Evans being out once again, Chris Godwin is out after making his season debut two weeks ago after a devastating ankle/leg injury early last year. The Bucs will also be without star running back Bucky Irving for the second week in a row, opening the door for Rachaad White.

The Buccaneers enter the weekend favored by 3, and the total for this big NFC tilt is 47.5.

Cincinnati Bengals at Green Bay Packers (4:25 p.m. ET)

The biggest injury news was on the Cincy side as all-world receiver Ja'Marr Chase was added to the injury report Friday with an illness. Chase was questionable to suit up, but he will play. That's big for a Bengals team breaking in a new quarterback with Joe Flacco now under center. 

The Packers won't activate Christian Watson this week as the speedy receiver recovers from a knee injury. The Packers' O-line is hurting right now, as three starters were questionable for Sunday, though they're all active.

The Packers are big 14.5-point favorites for Sunday, and the over/under is 44.5.

Detroit Lions at Kansas City Chiefs (8:20 p.m. ET)

These teams are in very different shape health-wise entering Sunday Night Football. The Chiefs have no players listed on their final injury report, while the Lions have 10, including three starting defensive backs, one of whom has already been ruled out. Left tackle Taylor Decker is also questionable after missing last week.

The Chiefs are 2.5-point favorites over the 4-1 Lions. The total is 52.5.

Buffalo Bills at Atlanta Falcons (7:15 p.m. ET, Monday)

Both sides have some nicks and bruises here, but the biggest name who will miss this game is Falcons receiver Darnell Mooney, who is battling a hamstring injury. Mooney has just seven catches for 79 yards this year after having 992 yards last year when he served as Atlanta's No. 2 option behind Drake London in the passing game.

The Bills are favored by 4.5 points in Atlanta after suffering their first loss of 2025. The total is 50. 

Chicago Bears at Washington Commanders (8:15 p.m. ET, Monday)

The Commanders got Jayden Daniels back after he missed two weeks with a knee injury, but his top target, Terry McLaurin, will not play Monday as he's sidelined with a calf injury. Deebo Samuel missed his share of practice last week with a heel injury but played on Sunday, and that same injury has him questionable for Monday.

Bears rookie tight end Colston Loveland is questionable after missing last week. 

Washington enters the weekend favored by 4.5 points. The total is up to 49.5. Since this game is on Monday, official injury designations will be announced Saturday.