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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Will be No. 1 back Sunday
Penny is expected to be the Seahawks' lead back Sunday at Arizona with Chris Carson (hip) sidelined, John Boyle of the team's official site reports.
Carson took a significant amount of contact last Sunday during a 32-carry performance, emerging with a hip injury. He entered the weekend as a game-time decision, but ultimately, the Seahawks will hold him out with his health in mind. Behind Penny, C.J. Prosise (abdomen) will be available, but the fact he's active after being deemed doubtful doesn't equate to a sunny forecast. Consequently, Penny is poised for his most work as a pro Sunday.
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Matt Breida RB | SF
49ers' Matt Breida: Playing Sunday
Breida (knee) is active for Sunday's road game against the Chargers, Matt Maiocco of NBC Sports Bay Area reports.
In the wake of hyperextending his right knee Week 3, Breida sandwiched limited practices around a full showing Thursday. Both Breida and Alfred Morris are suiting up after tending to knee injuries, so an even split of touches likely will be their reality for a fourth consecutive game.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Logs on-field workout
Mixon (knee), who is inactive for Sunday's game contest against the Falcons, was taking part in an on-field workout prior to the game, Paul Dehner Jr. of The Cincinnati Enquirer reports.
Dehner relays that Mixon looked good during the session, offering an encouraging sign for the running back's prospects entering the Week 5 matchup with the Dolphins. The Bengals likely won't have a better read on Mixon's availability for next weekend until the team reconvenes for practice Wednesday.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Gets Week 4 start
Wilkins will serve as the Colts' starting running back Sunday against the Texans with Marlon Mack (hamstring) inactive for the contest, George Bremer of The Anderson Herald Bulletin reports.
While Mack was sidelined for Weeks 1 and 3 with the same injury, Wilkins largely failed to make an impact, logging a combined 59 yards on 20 carries and 22 yards on five receptions. Wilkins actually ended up getting out-snapped by backup Nyheim Hines in the Week 3 loss to the Eagles by a 43-17 margin, so Wilkins' starting designation might not actually mean much for fantasy purposes.
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Ronald Jones RB | DAL
Buccaneers' Ronald Jones II: Set for NFL debut
Jones is active for the first time in his NFL career Week 4 against the Bears.
The second-round pick was sidelined by virtue of head coach Dirk Koetter's decision over the first three games of the season, but he'll finally have a chance to suit up against Chicago. The Buccaneers' running game has been relatively nondescript while being helmed by Peyton Barber over the first trio of contests, although game flow has at least partly affected the his opportunities. It remains to be seen how the Bucs' backfield workload will be divided Sunday, but Barber is likely to still log more than half of the running back touches for at least this week.
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Corey Clement RB | ARI
Eagles' Corey Clement: Inactive Week 4
Clement (quadriceps) is inactive for Sunday's contest at Dallas, Tim McManus of ESPN.com reports.
Clement played through the quad injury last Sunday against the Colts, when he notched 75 yards on 19 touches with both Jay Ajayi and Darren Sproles (hamstring) out of commission. However, Clement will join Sproles in street clothes Week 4, leaving the backfield work to Ajayi and Wendell Smallwood.
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Marlon Mack RB | ARI
Colts' Marlon Mack: Inactive for Week 4
Mack (hamstring) is inactive for Sunday's game against the Texans.
Mack's prospects of returning to action appeared promising after he logged a limited practice Wednesday, but his inability to advance to a full session by Friday may have closed the door on him suiting up Sunday. With Mack on the sideline for the third time in four games, Jordan Wilkins is expected to pick up the start at running back, though he'll likely share time with fellow rookie Nyheim Hines.
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Ronald Jones RB | DAL
Buccaneers' Ronald Jones II: Pro debut imminent?
Jones is expected to be active for Sunday's game at Chicago, Adam Schefter of ESPN reports.
The Buccaneers invested a 2018 second-round pick in Jones, only to include him among their inactives for the first three games of the season in favor of running backs Peyton Barber and Jacquizz Rodgers. Neither player has been particularly productive en route to the 30th ranked rush offense, so Jones may be tasked with jump-starting the Bucs' backfield. Still, it's difficult to envision a large workload for Jones if all three are active.
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Corey Clement RB | ARI
Eagles' Corey Clement: On track to play Week 4
Clement (quadriceps), who is listed as questionable for Sunday's game against the Titans, is expected to play, Ian Rapoport of NFL Network reports.
Clement was added to the injury report Thursday and was limited during the Eagles' final practice of the week, but the Eagles never seemed to express much concern about his availability for Sunday. Though he projects to suit up, Clement will likely see his opportunities out the backfield take a hit after logging a season-high 19 touches in the Week 3 win over the Colts. Jay Ajayi is set to return Sunday from a one-game absence due to a small back fracture and could reclaim a lead role for the Eagles.