NFL Player News

Coach Kyle Shanahan said Mostert (ankle) is unlikely to be activated from injured reserve before Sunday's game at New Orleans, but the 49ers hope to have the running back available for their first game after a Week 11 bye Nov. 29 versus the Rams, Matt Barrows of The Athletic reports.

Shanahan said the same of fellow running back Tevin Coleman (knee), which would leave the backfield in the hands of Jerick McKinnon, JaMycal Hasty and Austin Walter this weekend. Sunday's game will mark Mostert's sixth absence of the season.

Drake (ankle) was limited at Wednesday's practice, Darren Urban of the Cardinals' official site reports.

Deemed day-to-day by coach Kliff Kingsbury on Monday, Drake took a step on the right direction as he works to get past a slight tear of a ligament in his ankle, which so far has sidelined him for one game. Drake will look to build upon his progress as he attempts to return to action Sunday against the Bills.

Coach Matt Rhule said Wednesday that McCaffrey (shoulder) is "day-to-day" or "week-to-week," clarifying that the running back's AC joint injury won't be season-ending, Joe Person of The Athletic reports.

McCaffrey isn't expected to practice or play this week, and he's already scheduled for a second opinion on the shoulder. Meanwhile, Mike Davis is set for another stint in the lead back role, though it isn't likely to last for six games again, even if the 3-6 Panthers take a cautious approach with McCaffrey over the final two months of a rebuilding season.

Harris (chest) is present at Wednesday's practice, Zack Cox of NESN.com reports.

Harris was forced out of Monday's win over the Jets due to the chest injury, so it's encouraging to see him in attendance for practice just two days later. The second-year running back is also scheduled to speak with the media Friday, which isn't standard procedure for injured players. That said, until the actual extent of Harris' practice activity is revealed, his status will need to be monitored heading into the Patriots' Week 10 game against Baltimore.

Mixon (foot) was spotted rehabbing on a side field at Wednesday's practice, Paul Dehner Jr. of The Athletic reports.

Mixon isn't ready to resume participating in team drills, but it's at least encouraging to see that he's handling rehab work. Ben Baby of ESPN.com noted that coach Zac Taylor has been heartened by the running back's progress, but Mixon will still likely need to upgrade his practice activity over the next two days to have a shot at playing Sunday in Pittsburgh.

Gibson didn't practice Wednesday due to a shoulder injury, Sam Fortier of The Washington Post reports.

Gibson is coming off a career-low nine touches in Sunday's loss to the Giants, resulting in 55 yards from scrimmage and one touchdown. His offensive snap share (46 percent) wasn't out of the norm, but perhaps the shoulder issue forced Washington to use J.D. McKissic a bit more (12 touches, 83 percent share). In any case, Gibson's status will be one to watch as the weekend approaches to get a sense of his availability for Week 10.

Mixon (foot) won't participate in team drills in Wednesday's practice, Ben Baby of ESPN.com reports.

The report notes that coach Zac Taylor has been encouraged by the running back's progress, with Geoff Hobson of the Bengals' official site suggesting that Mixon could return to action as soon as Sunday against the Steelers. Mixon hasn't played since Week 6 due to the right foot injury.

Drake (ankle) was spotted at practice Wednesday, Darren Urban of the Cardinals' official site reports.

Heading into the week, coach Kliff Kingsbury deemed Drake day-to-day, and the running back's participation in practice Wednesday -- in any capacity -- confirms that he's moving in the right direction as Sunday's game against the Bills approaches. Another update on Drake's status will be available later Wednesday, when the Cardinals reveal the extent of his practice participation.

Coach Kevin Stefanski indicated that Chubb (knee) is "progressing," while adding that the Browns will make a call Friday on whether the running back will be activated from injured reserve ahead of Sunday's game against the Texans, Jake Trotter of ESPN.com reports.

The Browns designated Chubb to return from IR earlier this week, so he'll continue practicing Wednesday as the team continues to assess whether he's fit to return to the game action this weekend. If added back to the 53-man roster, Chubb would rejoin a backfield that also includes Kareem Hunt, who has been handling a three-down role while Chubb has been sidelined for the past four games.

McCaffrey's right shoulder injury is expected to sideline him for Sunday's game against the Buccaneers, Adam Schefter of ESPN reports.

Per David Newton of ESPN.com, the running back won't practice Wednesday and is seeking a second opinion on his shoulder injury, which he sustained in Sunday's 33-31 loss to the Chiefs in his return from a six-game absence due to a high-ankle sprain. Schefter suggests that McCaffrey is considered week-to-week at this stage, so he could end up missing time beyond this Sunday. Assuming McCaffrey is indeed officially ruled out by the Panthers later this week, Mike Davis would once again fill in as the team's feature back, as he did when McCaffrey was out earlier this season.