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Saquon Barkley RB | PHI
Eagles' Saquon Barkley: Doesn't practice Wednesday
Barkley (hamstring/back) was listed as a non-participant in Wednesday's walkthrough.
The Eagles are listing Barkley's previous hamstring injury and the back issue that he picked up during Monday's loss to the Cowboys as the reasons for Wednesday's absence. He'll have two more chances to mix into drills this week, but even if he isn't able to, he mentioned of the aforementioned contest that his "hamstring came out great" and that he isn't worried about the new health concern, per Tim McManus of ESPN. Ultimately, Friday's injury report will reveal Barkley's odds to suit up Sunday at Washington.
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Tyler Allgeier RB | ARI
Cardinals' Tyler Allgeier: Not spotted Wednesday
Allgeier was not present during the portion of Wednesday's practice open to the media, Tyler Drake of ArizonaSports.com reports.
It's unclear if Allgeier is dealing with a health concern or merely getting the day off, but Wednesday's practice report will reveal as much. Fellow RB Jeremiyah Love (ankle) is returning as a limited participant to begin Week 8 prep, throwing the Cardinals backfield in a bit of flux.
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Dylan Sampson RB | CLE
Browns' Dylan Sampson: Turns in limited practice
Sampson (knee) was a limited participant in Wednesday's practice.
Sampson's limitations were presumably maintenance-related after he suited up in Sunday's 27-24 win over the Titans following a five-game stint on injured reserve due to the knee injury. In his return to action, Sampson served as the No. 2 option out of the backfield behind Quinshon Judkins and carried six times for 45 yards while adding three receptions for 32 yards on three targets.
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Jaydon Blue RB | PHI
Eagles' Jaydon Blue: Joins active roster
The Eagles signed Blue from the practice squad to the active roster Wednesday.
Yet another Eagles RB landed on IR on Wednesday, with Dameon Pierce (undisclosed) joining Tank Bigsby (abdomen) and Will Shipley (foot). Blue thus was called up as a reinforcement and could be in line for a decent amount of work right away with Saquon Barkley (back) dealing with another health concern. Blue hasn't played in 2026 but turned 38 carries into 129 yards and one touchdown to go with one catch (on one target) for five yards in five appearances as a rookie fifth-rounder for the Cowboys last season.
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Dameon Pierce RB | PHI
Eagles' Dameon Pierce: Lands on injured reserve
The Eagles placed Pierce (undisclosed) on injured reserve Wednesday
Pierce thus is joining fellow RBs Tank Bigsby (abdomen) and Will Shipley (foot) on IR, leaving Saquon Barkley and Jaydon Blue as the only players at the position on the Eagles' active roster. Pierce made a late exit from Monday's loss to the Cowboys, which followed Barkley's own earlier departure due to a back issue. Pierce's health concern is enough for him to miss at least four contests, meaning his next chance for game action is Sunday, Dec. 6, in Arizona.
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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Will be limited Wednesday
Head coach Mike LaFleur said Love (ankle) will practice in a limited fashion Wednesday, Bo Brack of GoPHNX.com reports.
This doesn't come as a surprise, as LaFleur told Theo Mackie of The Arizona Republic on Monday that Love was slated to practice Wednesday. Now that Love's activity level is known, he'll have two more chances to get back to full this week before the Cardinals potentially make a ruling on his status ahead of Sunday's game at Dallas. Love has missed the last two games due to a lingering ankle injury, which has allowed Tyler Allgeier and Bam Knight to split the backfield reps during that span.
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Jaylen Wright RB | MIA
Dolphins' Jaylen Wright: Opens week with full practice
Wright (quadriceps/foot) was a full participant in Wednesday's practice, Marcel Louis-Jacques of ESPN.com reports.
Wright exited Sunday's 28-25 win over the Jets late in the fourth quarter on account of the quad issue, but his availability for this weekend's game against the Patriots doesn't look to be in any peril. Since returning to action Week 4 against the Vikings following a one-game absence, Wright has been a clear second fiddle to Ollie Gordon out of the Miami backfield. In his last three appearances, Wright hasn't recorded any receptions and has logged no more than six carries in any contest.
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Jahmyr Gibbs RB | DET
Lions' Jahmyr Gibbs: Held out due to shoulder injury
Gibbs (shoulder) did not practice Wednesday.
Several Lions stars did not practice Wednesday, but Gibbs' absence stood out because his shoulder issue had not been reported previously. Gibbs' practice participation now becomes a significant item for fantasy managers to monitor as the week progresses. The Lions head to Minnesota to face the Vikings on Sunday.
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Kenneth Gainwell RB | TB
Buccaneers' Kenny Gainwell: Held out Wednesday
Gainwell (hip) was held out Wednesday due to the injury he sustained against the Panthers, Scott Smith of the Buccaneers' official site reports.
Gainwell's hip issue cropped up in the win over the Panthers, but he was able to return later in the contest. Even so, he was held out of practice to begin prep for the Week 8 clash with the Falcons. His status will have an impact on the Bucs' running back rotation, seeing as Gainwell has played 35 percent of the offensive snaps thus far this season. Bucky Irving could have a larger role, and Sean Tucker could be more of a factor, if Gainwell is unable to play Sunday.
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Tyjae Spears RB | TEN
Titans' Tyjae Spears: Sits out Wednesday's practice
Spears (knee) didn't practice Wednesday.
After he sat out last week's loss to the Browns, Spears' absence to kick off Week 8 prep doesn't inspire much early confidence in his chances of playing this weekend against the Bengals. Tony Pollard took on a workhorse role while Spears was sidelined in Week 7 and could be ticketed for another sizable workload if Spears needs to miss another game.