Stewart will start at first base and bat fourth Saturday against the Red Sox.

Concerns regarding Stewart's health arose after he took a 110-mph Roman Anthony line drive off his wrist in the fifth inning of Thursday's contest, but Stewart said Saturday that he only feels a little sore and will continue to play, per Gordon Wittenmyer of The Cincinnati Enquirer. The 22-year-old infielder finished the season opener 3-for-4 with a pair of doubles and is poised to start most games at first base for the Reds, though he's also capable of covering second or third.

Santana started at first base and went 1-for-3 with a walk, a double and a run scored in Friday's 5-4 loss to the Dodgers.

Santana started the first two games of the regular season at first base against right-handers, while the lefty-swinging Pavin Smith dealt with an elbow issue early in the regular season. Those two are expected to share first base and DH early on. Designated hitter will become more crowded when Lourdes Gurriel (knee) is ready to rejoin Arizona. The soon-to-be 40-year-old Santana is coming off a 2025 season in which he posted a career-low .325 slugging percentage (11 HR, 22 XBH).

Manzardo started as the designated hitter and went 0-for-4 with four strikeouts in Friday's 5-1 loss to the Mariners.

Manzardo has been stuck at DH the first two games of the season, with both starts coming against right-handed pitchers. The right-handed-hitting Rhys Hoskins started at first in both games. There was some thought that Manzardo would see more time at first base this season with Carlos Santana no longer on the team, but those plans apparently changed when the Guardians signed Hoskins after spring training started.

France will start at first base and bat seventh in Friday's game versus the Tigers.

After the lefty-swinging Gavin Sheets started at first base Opening Day against southpaw Tarik Skubal, the Padres will go with the right-handed-hitting France versus lefty Framber Valdez. San Diego is expected to give Sheets plenty of run at first base against lefties this season, but France and Nick Castellanos will also be in the mix at the position.

Rice is out of the lineup for Friday's game against the Giants.

After going 1-for-4 with a walk and a run scored Wednesday, Rice will take a seat Friday afternoon against southpaw Robbie Ray. Paul Goldschmidt will draw the start at first base.

Caglianone isn't part of the starting lineup for Friday's game against Atlanta.

The lefty-hitting Caglianone will dodge a matchup with Chris Sale on Friday, allowing Starling Marte to draw the start in right field. Caglianone and Marte are expected to platoon to begin the season, but Caglianone could earn looks against left-handed pitching with a strong start.

O'Hearn went 2-for-4 with a solo home run and two runs scored Thursday against the Mets.

O'Hearn took Tobias Myers yard in the sixth inning to tally his first home run of 2026 as well as with the Pirates. O'Hearn led off the final frame with a single and came around to score his second run of the contest. He started in right field and hit fifth in the order, and he should continue to hold a prominent role in Pittsburgh's lineup against right-handed pitchers.

Aranda went 2-for-4 with a solo home run, a walk and an additional RBI in Thursday's 9-7 loss to the Cardinals.

The left-handed-hitting Aranda managed to take southpaw Matthew Liberatore yard for his first long ball of the season. The first baseman hit third in his season debut, which should help his fantasy upside while occupying a premium lineup spot. Aranda was a strong four-category producer when available for the Rays in 2025, batting .316 with 14 homers, 59 RBI and 56 runs scored over 370 regular-season at-bats (106 games).

Murakami went 1-for-2 with a solo home run and two walks in Thursday's 14-2 loss against the Brewers.

Murakami made a great impression in his big-league debut, reaching base three times and launching a 384-foot solo shot to lead off the ninth inning for his first career MLB home run. The 26-year-old also showed strong plate discipline, drawing two walks in the contest and looking comfortable at the plate on a day when Brewers pitchers recorded 20 strikeouts. The homer, which he pulled into the right-field corner, offered an early glimpse of the power that Murakami showcased in Japan, where he hit 246 home runs across eight seasons in Nippon Professional Baseball.

Stewart batted cleanup and went 3-for-4 with two doubles in Thursday's 3-0 loss to the Red Sox.

Reds manager Terry Francona began experimenting with Stewart batting fourth followed by Eugenio Suarez late in spring training and stuck with it for Opening Day against Boston left-hander Garrett Crochet. The 22-year-old Stewart collected three of the four hits Boston's ace would allow, and Stewart managed to stay in the game after taking a Roman Anthony line drive off the hand while playing the field. Stewart slashed .327/450/.592 during spring training with four doubles, three home runs and 11 RBI across 20 games and will be the Reds' mainstay at first base and part of the rotation at DH, but he could also be an option at second or third base.