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Injuries are a major part of the NFL and NFL betting, and that's certainly the case again this week. We've seen a large number of starting quarterbacks impacted by injuries both this season as a whole and of late, and that's the case again in Week 12. As we do every week, here are the biggest NFL injuries that bettors need to know, and what NFL betting lines look like according to the latest SportsLine consensus odds. We will update this post with inactives lists for every team prior to kickoff. 

Colts at Chiefs (1 p.m. ET)

This monster AFC clash is a big one for both sides, but especially a Chiefs team that's 5-5 and has lost six games in a season just three times since Andy Reid took over in 2013. The Chiefs will be without bruising running back Isiah Pacheco once again, while speedy receiver Xavier Worthy is questionable. 

Kansas City is favored by 3.5 points, and the total is 50.

Seahawks at Titans (1 p.m. ET)

The Seahawks are looking to rebound from a tough loss to the Rams, and they get a good bounce-back chance against a lowly Titans team. Seattle may be down starting running back Kenneth Walker III, who is questionable. That would pave the way for Zach Charbonnet to serve as the team's lead back. The Titans' passing attack has been awful this year and will be without rookie standout Elic Ayomanor.

The Seahawks are favored by 13 points. The total is 40.5.

Vikings at Packers (1 p.m. ET)

The Packers' deep wide receiver room is banged up, with three pass catchers either questionable or out for Week 12 against the Vikings. The bigger news is star running back Josh Jacobs is questionable after he left last week with a knee injury. If he can't go, Emanuel Wilson would start for Green Bay.

The Packers are 6.5-point favorites while the total is 41.5.

Jets at Ravens (1 p.m. ET)

The good news for the Ravens is Lamar Jackson has no designation after missing some practice time this week, but he won't have explosive receiver Rashod Bateman against a poor Jets defense. And the Jets are making a change at quarterback with Tyrod Taylor starting over Justin Fields, though not due to injury. 

The Ravens are favored by 13.5 points. The total is 44.5

Giants at Lions (1 p.m. ET)

  • NYG QB Jaxson Dart (concussion, out)
  • DET OL (four of five starters questionable)

The Giants again will be without standout rookie quarterback Jaxson Dart as he's out with a concussion. Jameis Winston will start for New York against a Lions team that has a number of players banged up, most notably along the offensive line where four of the five starters are questionable.

Detroit is favored by 12.5. The total is 50.

Steelers at Bears (1 p.m. ET)

The top injury here is the status of Aaron Rodgers. The veteran Steelers QB is questionable with a wrist injury, though it's his left wrist. If Rodgers can't start, longtime Pittsburgh backup Mason Rudolph would start for the Steelers.

The Bears are favored by 2.5 points. The total is 45.5.

Patriots at Bengals (1 p.m. ET)

This very well could be the return of Joe Burrow for the Bengals as the star quarterback is questionable to play Sunday. Burrow hasn't played since Week 2. If he does play, he won't have Ja'Marr Chase as the star receiver is suspended for this week. The Bengals will be without top defender Trey Hendrickson once again on that side of the ball. 

New England is favored by 7 points and the total is 51.5

Browns at Raiders (4:05 p.m. ET)

The Browns will be starting their third different quarterback this year as Dillon Gabriel is out with a concussion, opening the door for Shedeur Sanders to make his first career start after completing just four passes on 16 attempts off the bench last week. He faces a lackluster Raiders defense, though the Browns' offense is one of the NFL's worst units this year.  

Vegas enters the weekend favored by 3.5, while the total is 36.5, the lowest of the entire Week 12 slate. 

Jaguars at Cardinals (4:05 p.m. ET)

These two teams will both be down top playmakers. 2024 first-round picks Marvin Harrison Jr. and Brian Thomas Jr. are both out once again, and the Cardinals will be down Emari Demercado, who has seen more looks of late due to injuries to the team's running back room. Trey Benson has also been ruled out as he's not yet ready to return to action from an early season injury.

The Jags are 3-point favorites, and the total is 47.5.

Eagles at Cowboys (4:25 p.m. ET)

The Eagles' once dominant offensive line hasn't been quite up to its usual standards this year, and the offense as a whole has been a major problem. The team will have to do without longtime right tackle Lane Johnson in this rivalry clash with Dallas as he's out with a foot injury. 

Philly is a 3-point road favorite. The total is 47.5.

Falcons at Saints (4:25 p.m. ET)

This season has been more of a struggle for the Falcons than expected after nearly winning the NFC South last year, and they now are without quarterback Michael Penix Jr. for the rest of the year after he tore his ACL last week. Kirk Cousins will start the rest of the way, but he won't have star receiver Drake London this week. On the other side, New Orleans has listed top running back Alvin Kamara as questionable for this divisional clash.

New Orleans is a 2-point favorite, and the total is 40.5.

Buccaneers at Rams (8:20 p.m. ET)

The Bucs will have to do without running back Bucky Irving once again as the talented back will miss his seventh game of the year this week. The good news for Tampa is veteran receiver Chris Godwin, who has been out much of the year, could return as he's questionable for Sunday Night Football.

L.A. is favored by 6.5 points. The total sits at 49.5.

Panthers at 49ers (8:15 p.m. ET, Monday)

  • No notable injuries to report

Final injury reports for Monday Night Football come out on Saturday, though at the moment, no team has any notable players sitting out of practice. 

San Francisco is favored by 7 points, and the total is 49.5.