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Christian McCaffrey RB | SF
Panthers' Christian McCaffrey: Quiet in Sunday's win
McCaffrey rushed nine times for 39 yards and caught two of four targets for 19 yards in Sunday's 22-19 win over the Buccaneers.
McCaffrey and Carolina's offense as a whole struggled to get much going Sunday, but the rookie was once again handed more carries than starting tailback Jonathan Stewart. While that usage is reason for encouragement heading into next Sunday's finale versus the Falcons, so too is the fact that McCaffrey's season-high rushing output came against Atlanta in Week 9. In that game, he finished with 66 yards and a touchdown on 15 carries and 28 receiving yards on five receptions.
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Derrick Henry RB | BAL
Titans' Derrick Henry: Could serve as lead back for finale
Henry rushed eight times for 25 yards and added a six-yard catch on his lone target in Sunday's 27-23 loss to the Rams.
Henry played second fiddle to DeMarco Murray, who scored on a six-yard run in the third quarter. Murray had to be helped to the sideline after suffering a knee injury late in the fourth quarter and didn't return, so it's possible Henry will serve as the lead back in next week's must-win home clash with a Jaguars defense that's been sensational against the pass and middling defending the run.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Totals 90 scrimmage yards
Kamara carried 12 times for 32 yards and caught seven of nine targets for an additional 58 yards during Sunday's 23-13 loss to the Falcons.
Kamara managed just 2.7 yards per carry on the ground, but he was the most targeted Saints player on the day and padded his yardage total with some nice gains through the air. The rookie has now gone for at least 76 scrimmage yards in each of the last 12 games he's finished, and his effectiveness as a receiver has made him a top-notch fantasy asset, despite operating in a timeshare with Mark Ingram. Kamara will look to put an exclamation mark on what has been a remarkable rookie season Week 17 against the Buccaneers.
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Mike Gillislee RB | NE
Patriots' Mike Gillislee: Rushes for 28 yards, TD in Week 16
Gillislee carried six times for 28 yards and a TD and caught one pass for 15 yards in Sunday's 37-16 win over the Bills.
Gillislee did just enough to help those who rolled with him in Week 16, hoping he'd hit pay dirt in his return to the Patriots' backfield mix after a string of lineup scratches. Meanwhile, Dion Lewis exploded for 129 rushing yards on 24 carries, while catching five passes for 24 yards and scoring two TDs. How much work Gillislee sees Week 17 hinges on what the Patriots are playing for, as well as the health of fellow running backs Rex Burkhead (knee) and James White (ankle).
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Melvin Gordon RB | BAL
Chargers' Melvin Gordon: Runs for 81 yards, tweaks ankle Sunday
Gordon, who recorded 19 carries for 81 yards and a TD in Sunday's 14-7 win over the Jets, sustained an ankle injury in the contest.
Gordon also caught three passes for 47 yards Sunday to complete a solid Week 16 fantasy stat line, but his status will need to be monitored as the Chargers' regular-season finale approaches. With Austin Ekeler dealing with a hand injury, Branden Oliver served as Gordon's top backup this week, logging eight carries for nine yards.
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Akeem Hunt RB | KC
Chiefs' Akeem Hunt: Suffers shoulder injury
Hunt hurt his shoulder and is considered questionable to return to Sunday's game against the Chiefs.
Hunt was having himself a nice day on special teams before exiting, logging 76 yards on three kickoff returns. If he can't return Sunday, De'Anthony Thomas would presumably take over kickoff-return responsibilities.
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Samaje Perine RB | CIN
Redskins' Samaje Perine: Returns Sunday
Perine (Achilles) returned to Sunday's game versus the Broncos.
After sitting out a portion of the fourth quarter to have his Achilles examined, Perine was made available for the rest of the contest. If the injury persists into Week 17 prep, the hype surrounding reserve running back Kapri Bibbs could finally yield fruit in Washington.
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Samaje Perine RB | CIN
Redskins' Samaje Perine: Injures Achilles on Sunday
Perine is questionable to return to Sunday's game against the Broncos due to an Achilles injury.
Perine has been befallen by one of the few dreaded injuries, at least before the final diagnosis is known. Clearly, the Redskins are leaving the door open for reentry to the contest, but if he doesn't make another appearance, he'll finish Week 16 with 15 carries for 53 yards and three receptions (on as many targets) for 21 yards. In his stead, the Redskins will turn to Kapri Bibbs out of the backfield.
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Thomas Rawls RB | JAC
Seahawks' Thomas Rawls: Back in uniform Sunday
Rawls is active for Sunday's game against the Cowboys, the Seattle Times reports.
Rawls was inactive last weekend against the Rams, but he's back in uniform in Week 16 to serve as the Seahawks' No. 3 running back behind Mike Davis and J.D. McKissic. Meanwhile, the team made veteran Eddie Lacy a healthy scratch Sunday.
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Kerwynn Williams RB | KC
Cardinals' Kerwynn Williams: Active Sunday
Williams (quadriceps) is active for Sunday's game against the Giants, Darren Urban of the Cardinals' official site reports.
Williams sustained cracked ribs Week 12, but Adrian Peterson's placement on IR with a neck injury allowed the understudy to get another extended crack with the first-team offense. Over the last three games, Williams has settled in as the No. 1 running back, averaging 17.7 carries for 77 yards, but his first touchdown since the regular-season opener awaits.