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Kenyan Drake RB | GB
Cardinals' Kenyan Drake: Plans to suit up Sunday
Drake (ankle), who is listed as questionable for Sunday's game against the Bills, plans to play if he checks out well during a pregame workout, Ian Rapoport of NFL Network reports.
Drake has come along quicker than expected from the high-ankle sprain he sustained Oct. 25, and with the benefit of a Week 8 bye, he may only end up missing one game due to the injury. Before the Cardinals make a call on his Week 10 status, however, Drake will be watched closely in warmups before the coaching staff decides whether to make him active and how significant of a role to give him if he does indeed suit up. Because Drake was only a limited participant in practices Wednesday through Friday, the Cardinals may be reluctant to entrust him with handling his normal role right away, so expect Chase Edmonds to remain involved in the game plan regardless of Drake's status. Over his first seven games this season, Drake averaged 17 carries and 1.4 targets per contest.
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Matt Breida RB | SF
Dolphins' Matt Breida: Not expected to play Sunday
Breida, who is listed as questionable for Sunday's game against the Chargers due to a hamstring injury, "may be a week away from going," Ian Rapoport of NFL Network reports.
Rapoport's report essentially matches the one provided Saturday by Adam Schefter of ESPN, who noted that Breida will likely miss a second straight game this weekend. In the event that Breida is unable to go, the Dolphins' top Week 10 backfield options would include Jordan Howard (team-high 10 carries for 19 yards and a touchdown Week 9) and Salvon Ahmed (seven carries for 38 yards). Additionally, the Dolphins will also have recent trade acquisition DeAndre Washington available to make his team debut.
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Damien Harris RB | BUF
Patriots' Damien Harris: Hopes to play Sunday
Harris (chest/ankle), who is listed as questionable for Sunday's game against the Ravens, is "hopeful to play," Ian Rapoport of NFL Network reports.
Rapoport adds that Harris will be monitored closely in pre-game warmups as the Patriots look to ensure he experiences no setbacks before clearing him to suit up. With Sony Michel (quad) still on injured reserve, the Patriots' other backfield options are the versatile Rex Burkhead, change-of-pace back James White and rookie J.J. Taylor. Given that Sunday's game kicks off at 8:20 p.m. ET, there's an element of risk in counting on Harris -- who has emerged as New England's top early-down option -- in Week 10 fantasy lineups. In the event that he's scratched, last-minute plug-in options would include Burkhead and White, running backs in the mix for carries for Baltimore, and those on the two Monday night teams (Minnesota and Chicago).
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Travis Homer RB | PIT
Seahawks' Travis Homer: Increased duties on tap
Homer should rotate with DeeJay Dallas in Sunday's game against the Rams following news that Chris Carson (foot) and Carlos Hyde (hamstring) are out, Curtis Crabtree of Sports Radio 950 KJR Seattle reports.
Homer looked fully healthy in last week's loss to the Bills. While he gained just 16 yards on six carries, he caught all three targets for 64 yards, including a 50-yard reception. The game script favored him, too, as the Seahawks dug a deep hole right away and passed more than usual, keeping Homer on the field for his pass-blocking acumen. The second-year back out of Miami should have a handful of opportunities this Sunday, especially if it turns into a shootout, but Dallas may have more upside as an early down and goal-line back.
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DeeJay Dallas RB | MIN
Seahawks' DeeJay Dallas: Opportunity awaits Week 10
Dallas should rotate with Travis Homer during Sunday's game against the Rams following news that Chris Carson (foot) and Carlos Hyde (hamstring) are out, Curtis Crabtree of Sports Radio 950 KJR Seattle reports.
The Seahawks will play a third straight week with their top two running backs on the sidelines. Last week when the Seahawks were trailing almost the entire game, Homer led the backfield with a 48 percent snap share, and the two backs both handled nine touches. Homer finished with 80 total yards, including a 50-yard reception, and Dallas totaled 39 total yards and a score. While Dallas doesn't get much work in the passing game, he's the designated goal-line back and has rushed five times within the five-yard line over the past two games. He should have solid upside once again with a potentially high-scoring game on tap.
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Matt Breida RB | SF
Dolphins' Matt Breida: Trending down for Sunday
Breida (hamstring) isn't expected to play Sunday against the Chargers, Adam Schefter of ESPN reports.
The 25-year-old is officially listed as questionable for Sunday's contest, but it appears he hasn't progressed well since injury designations were announced Friday. Breida could step into the starting role if able to play since Myles Gaskin (knee) is sidelined, but he instead seems likely to miss his second straight contest due to the hamstring injury. If Breida is indeed unable to play against Los Angeles, Salvon Ahmed is poised to lead the backfield while Jordan Howard handles short-yardage and goal-line work.
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Kenyan Drake RB | GB
Cardinals' Kenyan Drake: Remains game-time decision
Drake (ankle) is expected to play Sunday against the Bills but will have his availability determined after a pregame workout, Adam Schefter of ESPN reports.
Coach Kliff Kingsbury said Friday the 26-year-old would be a game-time decision Sunday, and his outlook appears largely unchanged. Drake missed last week's loss to Miami due to the slight ligament tear in his ankle, but thanks to the Week 8 bye he may only end up missing one game. Chase Edmunds handled nearly all the backfield reps in his place and figures to do so again versus Buffalo should Drake be unable to take the field.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Out again Sunday
Mixon (foot) was officially ruled out ahead of Sunday's contest against the Steelers, Adam Schefter of ESPN reports.
The only thing surprising about this designation is that it didn't come sooner considering Mixon was unable to practice all week. Giovani Bernard will once again get the start in a difficult matchup with Samaje Perine expected to aid as a complementary piece.
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Cordarrelle Patterson RB | PIT
Bears' Cordarrelle Patterson: More work in store?
Patterson could be in line for more opportunities after David Montgomery (concussion) was ruled out ahead of Monday's game.
Patterson is technically listed as the No. 2 option behind Montgomery, but it's fair to question if the Bears would expect the nimble specialist to operate in a similar capacity. The 29-year-old did carry the ball 21 times over a two-week stretch with the Patriots back in 2018, but he's otherwise seen more than six carries one either time in his career -- Week 2 against the Giants following Tarik Cohen's season-ending knee injury. While Patterson will likely play the most snaps of any Bears running back, expect to see a combination of Ryan Nall, Artavis Pierce and even practice-squad call-up Lamar Miller also take a handful of carries in a clear committee approach.
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David Montgomery RB | HOU
Bears' David Montgomery: Ruled out Monday
Montgomery (concussion) will not play in Monday's matchup against the Vikings.
Montgomery was unable to practice all week, and it looks like the team will err on the side of caution with its second-year running back. The team has a Week 11 bye, so his next chance to return will come in Week 12 versus the Packers. In his absence, Chicago will go to Cordarrelle Patterson as their primary option in the backfield, while Ryan Nall and Artavis Pierce will also be available. It should be noted the team could also elevate Lamar Miller from the practice squad.