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David Montgomery RB | HOU
Bears' David Montgomery: Lands on IR
Chicago placed Montgomery (knee) on injured reserve Saturday, Larry Mayer of the Bears' official site reports.
Montgomery will be sidelined for at least three games due to the sprained left knee after being placed on IR, with Ian Rapoport of NFL Network relaying that the Bears are eyeing a 3-to-5-week window for the running back's return. Damien Williams is poised to head Chicago's backfield for the time being, with rookie sixth-round pick Khalil Herbert also a candidate to see his role grow in the coming weeks.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Expected to play Sunday
Broncos head coach Vic Fangio expressed confidence Gordon (lower leg) will play Sunday against the Steelers, despite the running back being listed as questionable after practicing in a limited fashion Thursday and Friday, George Stoia III of The Denver Gazette reports.
Official confirmation of Gordon's Week 5 status will arrive prior to the first wave of games Sunday, with the Broncos kicking off at 1 p.m. ET. Assuming he suits up, as expected, Gordon will continue to operate in a backfield timeshare with rookie Javonte Williams.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Trending toward suiting up Sunday
Mixon (ankle), who is listed as questionable for Sunday's game against the Packers, went through a workout Saturday and is trending toward playing "in some capacity" Week 5, Tom Pelissero of NFL Network reports.
The running back failed to practice Wednesday through Friday, but he evidently looked good enough during Saturday's workout to have a chance to suit up versus Green Bay. If Mixon avoids the inactive list in advance of Sunday's 1 p.m. ET kickoff, it's unclear if he would be in line for his usual workload. With that in mind, if Mixon is limited at all, Samaje Perine and Chris Evans would be in store for added backfield work.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Misses practice
Wilkins was a non-participant at Friday's practice due to an illness.
Wilkins was a full participant at Thursday's practice, so he presumably began feeling under the weather after that time. More clarity on his status will be gained via Saturday's practice report.
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Eno Benjamin RB | NO
Cardinals' Eno Benjamin: Nursing injury in Week 5
Benjamin is listed as questionable for Sunday's game against the 49ers due to a hamstring injury, Darren Urban of the Cardinals' official site reports.
Benjamin has either been a healthy inactive or has dressed without playing in each of the Cardinals' 20 regular-season games since he was drafted in the seventh round in 2020, but for the first time in his career, he could be at risk of missing a contest for an injury-related reason. He was a limited participant throughout the week due to the hamstring issue.
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Chuba Hubbard RB | CAR
Panthers' Chuba Hubbard: Likely getting another start Week 5
Hubbard is expected to remain the Panthers' starting running back for Sunday's game against the Eagles with top option Christian McCaffrey (hamstring) listed as doubtful for the contest, David Newton of ESPN.com reports.
Though McCaffrey and head coach Matt Rhule consistently expressed optimism throughout the week about the former's recovery from the hamstring injury, McCaffrey looks set to miss his second straight game after he managed only limited participation in practices Wednesday through Friday. Unless McCaffrey exhibits remarkable progress heading into Sunday, he'll yield starting duties to Hubbard, who played 47 percent of the offensive snaps in the Panthers' Week 4 loss to the Cowboys and finished with 71 yards on 15 touches (13 carries, two catches). A negative game script for most of that contest resulted in Hubbard losing some passing-down work to Rodney Smith, but the rookie could be in better position to deliver a more useful fantasy line Week 5. Not only are the Panthers home favorites in the contest, but Hubbard will also be facing off against the NFL's 31st-ranked run defense.
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Nyheim Miller-Hines RB | NO
Colts' Nyheim Hines: Logs limited practice
Hines (shoulder) was a limited participant in Friday's practice.
Hines' return to the field Friday after missing Thursday's practice bodes well for his chances of suiting up Monday against the Ravens. The Colts will release their final injury report of the week Saturday, when it will be known whether Hines carries an injury designation into Monday's contest.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Deemed questionable for Sunday
Gordon (lower leg) is listed as questionable for Sunday's game against the Steelers, Aric DiLalla of the Broncos' official site reports.
Gordon is nursing a lower-leg contusion coming out the Week 4 loss to the Ravens, and the injury kept him from practicing Wednesday before he returned to the field in a limited capacity Thursday and Friday. Even though Gordon will take a designation into the weekend, Jeremy Fowler of ESPN.com relays that the 28-year-old is expected to play. If that's the case, Gordon will likely find himself in a near-even timeshare with rookie Javonte Williams.
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Truly questionable for Week 5
Edmonds (shoulder) was a limited practice participant Friday and is listed as questionable for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.
The official designation became a foregone conclusion when head coach Kliff Kingsbury called Edmonds a game-time decision earlier Friday after the running back returned to practice (he sat out sessions Wednesday and Thursday). If Edmonds ends up on the inactive list ahead of Sunday's 4:25 p.m. ET kickoff, James Conner could find himself in a not-at-all-unfamiliar three-down role. Reserve Eno Benjamin (hamstring) is also questionable, leaving Conner and Jonathan Ward as the truly healthy backfield options for the Cards. Edmonds, if he plays, is still probably the safest bet for production, while Conner has been more of an all-or-nothing fantasy play due to his reliance on goal-line touchdowns.