Perez gave up two hits, including a solo home run, in two-thirds of an inning Wednesday to record his first hold of the season in an extra-inning loss to the Phillies.

The 29-year-old lefty entered the game with two outs in the seventh inning and retired Kyle Schwarber, but Bryce Harper then took Perez deep to lead off the eighth as the Nationals' bullpen squandered a 5-0 lead. Perez may not hang onto a high-leverage role much longer if he can't keep the ball in the park -- he's served up two homers in his first three appearances and 2.2 innings this season, although his 3:0 K:BB is more promising than his 6.75 ERA.

Wiemer went 2-for-4 with a walk and two runs scored in Wednesday's extra-inning loss to the Phillies.

The 27-year-old continued his blistering start to the season. Wiemer has started five of the Nationals' first six games and racked up a .588/.682/1.059 slash line in 22 plate appearances with a triple, two homers, four RBI, seven runs and a 5:4 BB:K. Nothing in Wiemer's track record suggests he'll keep up anything close to that pace -- he sports a career 29.2 percent strikeout rate against an 8.6 percent walk rate in the majors -- but he's providing exceptional production so far for deep-league fantasy GMs who took a chance on him.

Semien went 0-for-4 with a walk and two strikeouts in Wednesday's extra-innings loss to the Cardinals.

The 35-year-old second baseman missed chances to play hero for the Mets in both the ninth and 11th innings, recording the final out with runners in scoring position each time. Semien is struggling to find a rhythm at the plate to begin his first season in New York, going 2-for-20 with a double, two RBI and a 3:8 BB:K through six games, but his still-excellent defense will keep him in an everyday role for now and provide him with plenty of leash to figure things out.

The Pirates will call up Griffin from Triple-A Indianapolis prior to their home opener Friday versus the Orioles, Jason Mackey of MLB.com reports.

Griffin came up just short for an Opening Day roster spot, but he will make his major-league debut as the Pirates kick off their first homestand of the season. The Pirates and Griffin have had discussions about a long-term contract extension for the 19-year-old, but while those talks will continue, Mackey says there is not currently a deal in place. Arguably the top prospect in baseball, Griffin has hit .438 with a 1.196 OPS and a 5:4 BB:K in the early going at Indianapolis. He slashed .333/.415/.527 with 21 home runs and 65 stolen bases across three levels in his first professional season in 2025. Griffin will take over at shortstop in Pittsburgh, shifting Jared Triolo either to third base or into more of a utility role.

Pauley went 2-for-4 with two doubles and a run scored in Wednesday's win over the White Sox.

The 25-year-old played his part in a 10-0 rout, collecting his first extra-base hits of the season. With Christopher Morel (oblique) and Kyle Stowers (hamstring) on the shelf and Griffin Conine (illness) unavailable as well Wednesday, Pauley got the start at first base while Connor Norby was the DH and Javier Sanoja handled the hot corner. As Pauley puts his spring forearm injury further behind him and gets back up to speed, however, he could emerge as the Marlins' preferred option at third base against right-handed pitching. Through five games to begin the season, he's gone 3-for-13 with a run scored, an RBI and a 0:5 BB:K.

Sanoja went 2-for-4 with a double and two RBI in Wednesday's rout of the White Sox.

Miami's offense didn't need to do much with Sandy Alcantara twirling a shutout, but it broke out for 10 runs anyway, with Sanoja being one of four Marlins with multiple hits. The 23-year-old utility player has seen most of his action at third base in the early going as Connor Norby has been needed elsewhere, and Sanoja's taken advantage of his opportunities by going 7-for-12 (.583) with two doubles, three RBI and a run scored.

Burke will be used in a bulk-relief role for Friday's home opener versus the Blue Jays, LaMond Pope of the Chicago Tribune reports.

Grant Taylor will serve as an opener for the White Sox before handing things off to Burke. The 26-year-old Burke fared quite well in 2025 when used as a bulk reliever, posting a 2.97 ERA and 38:10 K:BB over 30.1 innings covering six outings. Burke yielded four runs (three earned) with a 5:1 K:BB over four frames in a traditional start versus the Brewers this past weekend.

Taylor will be the White Sox' opening pitcher in Friday's game against the Blue Jays, LaMond Pope of the Chicago Tribune reports.

Taylor will take the ball first as the White Sox begin their first homestand of the season before handing things off to Sean Burke, who will handle the bulk of the innings. The 23-year-old Taylor has tossed one inning in each of his first two appearances this season but is expected to eventually stretch out to cover multiple frames, as his goal is to reach 100 innings in 2026 before moving into the rotation in 2027.

Rogers gave up two hits in a scoreless inning of relief to record his second hold of the season in Wednesday's loss to the Rockies.

The veteran sidearmer was the first man out of the bullpen for Toronto after Kevin Gausman had dominated for six scoreless innings, and Rogers kept the shutout going before the team's other relievers stumbled late. Rogers has seen a heavy workload to begin his Blue Jays tenure, appearing in four of the season's first six games and posting a 0.00 ERA, 0.75 WHIP and 3:1 K:BB.

Clement went 2-for-4 in Wednesday's loss to the Rockies.

The 30-year-old has had a quick start to the year, going 8-for-25 (.320) through six games with three doubles, two RBI and one run. Clement is shifting from a super-utility role to being the Blue Jays' everyday starter at second base this season, but so far that adjustment hasn't impacted him at the plate.