Wade is absent from the lineup for Wednesday's game in Houston.

Left-hander Framber Valdez will start for the Astros, so the lefty-hitting Wade will begin the series finale on the bench. Casey Schmitt will fill in at first base and bat fifth.

Busch is out of the lineup for Wednesday contest against the Athletics.

Southpaw Jeffrey Springs is on the bump for the Athletics, so the left-handed-hitting Busch will begin the series finale on the bench. Justin Turner will start at first base and bat cleanup for the Cubs.

Vaughn is not in the lineup for Wednesday's game against the Twins.

It's the first day off this season for Vaughn, who is 3-for-19 with a home run in the first five contests. Nick Maton will start at first base and bat leadoff for the White Sox on Wednesday.

Burleson is out of the lineup for Wednesday's game against the Angels.

Through the first six games of the season, the Cardinals have faced left-handed starting pitchers two times, and the lefty-hitting Burleson has checked out of the lineup on both occasions. The right-handed-hitting Luken Baker will replace Burleson as the Cardinals' designated hitter Wednesday while southpaw Yusei Kikuchi takes the hill for the Angels.

Encarnacion-Strand (hand) will start at first base and bat sixth in Wednesday's contest versus the Rangers.

Encarnacion-Strand didn't play Tuesday after leaving Monday's game following a hit-by-pitch on the right hand, but it will be just a one-game absence for the infielder. The 25-year-old is 4-for-14 with one home run in the early going this season.

Freeman (ankle) is absent from Tuesday's lineup against Atlanta.

This is the second straight game during which Freeman is not in the lineup for the Dodgers after aggravating his right ankle at home while in the shower Monday. This is the same ankle that the 35-year-old sprained in 2024 and that has yet to completely heal. He underwent imaging and the X-rays came back negative Tuesday, Fabian Ardaya of The Athletic reports. As Freeman nurses his ankle, Enrique Hernandez has the start at first base again.

Rodriguez is absent from the lineup for Tuesday's game against the Rays.

Rodriguez has garnered three starts at first base and one start at catcher in the early going, but he will begin Tuesday's tilt on the bench. Enmanuel Valdez will handle first base, and Joey Bart will do the catching for Pittsburgh.

Pasquantino is not in the lineup for Tuesday's game in Milwaukee.

Pasquantino started each of the Royals' first four games of the season, although he's been limited to designated hitter duty as he comes back from a hamstring injury. MJ Melendez will be the club's DH on Tuesday, while Cavan Biggio will cover first base.

Aranda is not in the lineup for Tuesday's game against the Pirates, Ryan Bass of FanDuel Sports Network Sun reports.

Aranda has gone 5-for-9 with four doubles, an RBI and two runs in the first four games of the season but will take a seat for Tuesday's contest. Curtis Mead will receive the start at first base versus Pittsburgh righty Thomas Harrington.

Goldschmidt will start at first base and bat leadoff in Tuesday's game versus the Diamondbacks.

When Goldschmidt batted leadoff in the Yankees' second game of the season, the feeling was that it was only because the club was facing a left-hander. However, he has now remained at the top of the batting order in the two contests since then as well, and both of them have been against righties. The Yankees have scored a whopping 32 runs in two games with Goldschmidt in the leadoff spot, so manager Aaron Boone doesn't feel the need to switch things up. After hitting leadoff Opening Day, Austin Wells is batting sixth for the third game in a row.