NFL Player News

Despite a positive COVID-19 test Nov. 20, Aiyuk told Cam Inman of The San Jose Mercury News on Friday that he's "feeling fresh physically and mentally" in advance of Monday night's game against the Bills.

Aiyuk missed one game as a result, but with three full days of practice under his belt he's set to resume his standing as one of the 49ers' top receivers. While Deebo Samuel is the clear No. 1 option, Aiyuk has averaged 12.7 YPC and 8.0 YPT while scoring three touchdowns on his 56 targets this season.

Samuel (hamstring) returned to practice as a full participant Friday, Nick Wagoner of ESPN.com reports.

Samuel's ability to take every rep at Friday's session confirms his absence from practice Thursday was precautionary, just as head coach Kyle Shanahan suggested was the case. The second-year wideout shouldn't face any limitations versus the Bills on Monday, when he'll be looking to build on the season-best performance he submitted in the 49ers' Week 12 win over the Rams (11 catches for 133 yards on 13 targets).

Peoples-Jones is slated to serve as the Browns' No. 3 wideout Sunday against the Titans, Scott Petrak of the Elyria Chronicle-Telegram reports.

Peoples-Jones has made his biggest impact for the Browns as a return man in recent weeks, but he'll get the chance to fill a regular spot in three-receiver sets Sunday while KhaDarel Hodge (hamstring) is sidelined. Don't expect the rookie sixth-round pick to see much work in the passing game, however, as the Browns have been the most run-heavy offense in the NFL this season.

St. Brown (knee) won't carry an injury destination into Sunday's game versus the Eagles, Wes Hodkiewicz of the Packers' official site reports.

St. Brown showed some flashes in this past Sunday's win over the Bears, finishing with two receptions for 39 yards -- both season highs -- and a seven-yard carry over 38 snaps. He'll look to build on that effort and continue establishing himself in the Packers offense against a strong Eagles secondary that has let up just 210.7 passing yards per game (seventh-fewest in the league).

Jeudy (ankle) is listed as questionable for Sunday's contest at Kansas City, Aric DiLalla of the Broncos' official site reports.

After logging time in every practice this week, Jeudy is trending in the right direction toward an appearance this weekend. Earlier Friday, coach Vic Fangio told Jeff Legwold of ESPN.com that he expects Jeudy to suit up Sunday, and he "won't be limited much" if he does, per Zac Stevens of TheDNVR.com. Jeudy has earned at least 50 percent of the offensive snaps and as much as 89 percent in each of the first 11 games of his career, but his output has been a bit sporadic.

Brown (hip) practiced fully Friday and is "good to go" for Sunday's game against the Browns, Jim Wyatt of the Titans' official site reports.

Brown sat out Thursday's practice, but the wideout's full participation Friday led to him heading into the weekend minus an injury designation. Through nine games to date, Brown has caught 40 of his 65 targets for 638 yards and eight TDs. The 2019 second-rounder has yet to log double-digit target volume in any games this season, but the fact that he's scored in all but two of the contests he's suited up for gives him a stable fantasy floor in his starting role with the Titans.

Ridley (foot/ankle) doesn't have an injury designation for Sunday's game against the Saints, Katherine Terrell of The Athletic reports.

Ridley's two injuries limited his activity in practices Wednesday through Friday, but the fact that the Falcons aren't even labeling him as questionable for the Week 13 contest implies that neither the foot nor the ankle issue is a significant concern. Fellow wideout Julio Jones (hamstring) also was unable to practice in full at any point this week, and though he's listed as questionable, he too expects to play. During the Falcons' Week 11 matchup with New Orleans, Ridley and Jones combined for a modest seven receptions for 119 yards, but the wideout tandem could be in store for bigger games in the rematch with the Saints down starting cornerback Janoris Jenkins (knee).

Harris (neck) is listed as questionable for Sunday's game against the Falcons.

Harris hasn't practiced all week, so he seems more likely to sit out than suit up for this one. With Marquez Callaway (knee) ruled out, the Saints will likely search deep down their depth chart for options in the return game should Harris sit. Taysom Hill and Alvin Kamara are both capable of filling such roles, but the team is unlikely to risk injury to its current starting quarterback or running back by subjecting them to unnecessary hits on special teams.

Agholor (ankle) does not carry an injury designation for Sunday's game against the Jets.

Agholor was limited Friday after having missed the first two practices of the week, but it doesn't appear as though his availability for Week 13 was ever in serious jeopardy. He's recorded 205 yards over Las Vegas' last four games while working as one of Derek Carr's top weapons.

Lazard (core) doesn't have a designation for Sunday's game versus the Eagles.

The Packers capped Lazard's practice reps all week, the residual effect of his Oct. 1 core muscle surgery. In two outings since he returned, his stat lines have been modest, as he's combined for six catches, 41 yards and one touchdown on 10 targets. Still, Lazard ostensibly is the No. 2 wide receiver in the Packers' top-ranked scoring offense (31.7 points per game).