Enright (elbow) was designated for assignment by the Guardians on Tuesday, Zack Meisel of The Athletic reports.

Enright loses his 40-man spot on Rule 5 deadline day after undergoing Tommy John surgery shortly after the end of the 2025 regular season. He will miss all of 2026, but Enright showed real promise before going down with a 2.03 ERA and 1.16 WHIP over 31 innings out of the Cleveland bullpen, numbers which may attract a team on the other end of the competitive spectrum.

The Red Sox traded Bernardino (lat) to Colorado on Tuesday in exchange for Braiden Ward, Patrick Saunders of The Denver Post reports.

Bernardino enjoyed a strong 2025 season with Boston, posting a 3.14 ERA, 1.26 WHIP and 43:26 K:BB over 51.2 innings while notching one save and two holds. The southpaw ended the campaign on the IL due to a strained lat, but there's no reason at this point to think that the injury will affect his availability for the start of spring training. Bernardino should immediately become a key member of a Rockies bullpen that ranked second-to-last in the majors with a 5.18 ERA last year.

Rainey was designated for assignment by the Tigers on Tuesday, Cody Stavenhagen of The Athletic reports.

Rainey's relevance in the fantasy world was fleeting, as he quickly fell off the map after the 2020 season. He has bounced from Washington to Pittsburgh to Detroit in recent years while mostly struggling on the mound. He pitched to an ugly 11.17 ERA and 1.76 WHIP over 9.2 major-league innings in 2025.

The Orioles selected Foster's contract from Triple-A Norfolk on Tuesday.

The 26-year-old was acquired from the Mets in the Gregory Soto trade over the summer, so his addition to the 40-man roster was to be expected. Foster pitched in 13 games for Triple-A Norfolk after the trade and had a 3.38 ERA, 1.38 WHIP and 23:8 K:BB over 16 innings.

The Cardinals designated Alcala for assignment Tuesday, John Denton of MLB.com reports.

Alcala struggled to find his footing on the mound in 2025, finishing the regular season with a 6.22 ERA and 1.75 WHIP across 55 total innings between Minnesota, Boston and St. Louis. He'll have the right to elect free agency if he clears waivers, although he will likely have to settle for a minor-league deal if he does so.

The Tigers designated Mattison for assignment Tuesday, Cody Stavenhagen of The Athletic reports.

Mattison was added to the 40-man roster last November, but he finds himself on the other side of Rule 5 cutdown day this time around. The right-hander has yet to make his major-league debut. He pitched mostly between Double-A and Triple-A this past season after recovering from right UCL reconstruction surgery.

Little was designated for assignment by the Tigers on Tuesday, Cody Stavenhagen of The Athletic reports.

Claimed off waivers from the Pirates earlier this month, Little ended up spending less than two weeks on the Tigers' 40-man roster. Little will now be subjected to waivers once again after spending the 2025 season primarily at the Triple-A level, making just a pair of relief appearances with the Dodgers over the summer.

Guenther (hip) was designated for assignment by the Tigers on Tuesday, Cody Stavenhagen of The Athletic reports.

Left hip surgery ended Guenther's season in early July after he made nine appearances (one start) with the big-league club over the first two months of the campaign. The left-hander put an impressive 0.86 ERA and 0.52 WHIP in 21 innings out of the Detroit bullpen during the 2024 regular season, and that run of success may be enough to land him on another team's 40-man roster.

The Tigers designated Foley (shoulder) for assignment Tuesday, Cody Stavenhagen of The Athletic reports.

Widely considered the favorite to close for Detroit entering 2025 spring training, Foley didn't even end up making it to Opening Day, with the Tigers choosing instead to send him to Triple-A Toledo. A right shoulder strain then put Foley on the injured list just weeks into the campaign, leading to season-ending arthroscopic surgery in May. While Foley resumed throwing before the end of the regular season, his status for the start of the 2026 season is uncertain.

Darnell (hip) was designated for assignment by the Tigers on Tuesday, Cody Stavenhagen of The Athletic reports.

Darnell received his first big-league call-up in August and made nine appearances with the Rockies before landing on the injured list with left hip inflammation. Surgery was deemed necessary, and Darnell has since jumped to Pittsburgh and Detroit on waivers. He will be subjected to the waiver process once again after being DFA'd.