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Carlos Santana 1B | ATL
Mariners' Carlos Santana: Absent from Saturday's lineup
Santana isn't starting Saturday against the Astros.
Santana will head to the bench after he hit .050 with a double, three RBI and three strikeouts over the last five games. Ty France is starting at first base while Kyle Lewis serves as the designated hitter.
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Ryan Mountcastle 1B | BAL
Orioles' Ryan Mountcastle: Not starting Saturday
Mountcastle isn't starting Saturday against the Reds, Rich Dubroff of BaltimoreBaseball.com reports.
Mountcastle has hit just .065 with three RBI and a run over eight games since the All-Star break, and he'll have a chance to reset Saturday. Trey Mancini is shifting to first base while Terrin Vavra serves as the designated hitter.
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Josh Naylor 1B | SEA
Guardians' Josh Naylor: Scratched with right ankle soreness
Naylor was scratched from Saturday's lineup against the Rays due to right ankle soreness, Zack Meisel of The Athletic reports.
Naylor sat out Friday against Tampa Bay and is apparently dealing with an ankle injury that will keep him out of the lineup for a second consecutive game. Whether he's available off the bench remains to be seen, but Owen Miller will take his place at first base and bat cleanup.
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Nick Pratto 1B | TEX
Royals' Nick Pratto: Retreats to bench
Pratto isn't starting Saturday against the Yankees, Joel Goldberg of Bally Sports Kansas City reports.
Pratto started the last two games and went 1-for-6 with a triple, two walks and three strikeouts. Vinnie Pasquantino will man first base while Maikel Garcia stays in the lineup at shortstop for a third straight game.
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Anthony Rizzo 1B | NYY
Yankees' Anthony Rizzo: Not starting Saturday
Rizzo isn't in the lineup Saturday against the Royals.
Rizzo started the last seven games and slashed .240/.387/.520 with two homers, a double, five runs, two RBI, two walks and three strikeouts. He'll get a breather while Aaron Judge serves as the designated hitter with Aaron Hicks starting in center field.
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Kole Calhoun 1B | CLE
Rangers' Kole Calhoun: Out against southpaw
Calhoun is not in Friday's lineup against the Angels.
Calhoun heads to the bench with lefty Patrick Sandoval on the hill for the Halos. Elier Hernandez will start in left field and bat seventh.
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Andrew Vaughn 1B | MIL
White Sox's Andrew Vaughn: Steps out of lineup
Vaughn is not in the lineup for Friday's game against the Athletics.
Vaughn is 3-for-20 with a double, a walk, an RBI and two runs since the All-Star break and will take a seat Friday versus Oakland. Yasmani Grandal will rest his legs as the designated hitter while Reese McGuire works behind the plate.
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Josh Naylor 1B | SEA
Guardians' Josh Naylor: Not in Friday's lineup
Naylor isn't starting Friday against the Rays.
Naylor started the last six games and hit .308 with a home run, three doubles, three runs, two RBI and a stolen base. Owen Miller is taking over at first base and batting cleanup.
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Alex Kirilloff LF | MIN
Twins' Alex Kirilloff: Not starting Friday
Kirilloff is out of the lineup for Friday's game at San Diego.
Kirilloff is 0-for-8 with three strikeouts since the end of his nine-game hit streak earlier this week, and he'll head to the bench Friday with southpaw Blake Snell pitching for the Friars. Kyle Garlick will take over in left field for Minnesota.
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Luke Raley RF | SEA
Rays' Luke Raley: Takes seat Friday
Raley isn't starting Friday against the Guardians, Marc Topkin of the Tampa Bay Times reports.
Raley has gone 7-for-19 with a homer, two doubles, three RBI and two runs over the last six games but will get a day off Friday. Josh Lowe is shifting to right field while Roman Quinn starts in center.