Thompson (ankle) won't play in San Francisco's Week 4 matchup versus the Broncos, Jennifer Lee Chan of NBC Sports Bay Area reports.
Thompson is in line to miss a second consecutive game due to the high-ankle sprain he suffered during the Week 2 win over the Dolphins. While there's currently no timetable for his return, his next chance to play will be the Week 6 matchup against Seattle.
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49ers' James Thompson: Likely to miss action moving forward
Rotowire
Thompson suffered a high-ankle sprain during Sunday's 35-13 win over Miami, David Lombardi of SFStandard.com reports.
Thompson sustained the injury in the second half of the victory, and he will now likely be forced to miss some time moving forward. In his absence, the 49ers will have to add another interior defensive lineman to their active roster.
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49ers' James Thompson: Dealing with ankle injury
Rotowire
Thompson (ankle) is questionable to return to Sunday's contest against Miami, Eric Branch of the San Francisco Chronicle reports.
Thompson was slow to get up before ultimately going to the locker room in the second half. His status for the rest of the game is now in the air, but his absence won't have a major impact on the team's defensive approach.