Bosa (calf) has been ruled out ahead of Sunday's game against the Cardinals.
Coach Kyle Shanahan said that Bosa is expected to miss "a few weeks" with a calf issue, Matt Barrows of The Athletic reports. It is unclear if Bosa will need to miss the minimum of four games that placement on IR would require. Even if he must miss more than four games, the team may not place the 28-year-old on IR anyway because it has almost reached its limit of eight designated-to-return players.
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49ers' Nick Bosa: Injures calf, likely out multiple weeks
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Bosa injured his calf during Thursday's practice and is expected to miss "a few weeks," according to Adam Schefter of ESPN.
Schefter reports that the 49ers aren't yet sure if Bosa will go on injured reserve. Either way, he's apparently set to miss multiple games, leaving a top-heavy roster without one of its superstars.
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49ers' Nick Bosa: DNP with lower-body injuries
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Bosa (calf/knee) did not participate in Thursday's practice, Jennifer Lee Chan of NBC Sports Bay Area reports.
It's the second day in a row in which Bosa has been held out of practice due to knee and calf injuries. His practice participation Friday will provide more clarity on his status ahead of Sunday's NFC West showdown against the Cardinals. Romello Height (hand) is also working through an injury, so Ogbo Okoronkwo and Khalid Kareem could operate in expanded roles against Arizona, depending on the statuses of both Bosa and Height.
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49ers' Nick Bosa: Has strong first game back
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Bosa made four tackles (three solo) in the 49ers' 27-7 Week 1 victory over the Rams.
Bosa showed out as a run defender during his first game back from an ACL injury that he suffered in Week 3 of the 2025 season. The defensive end didn't notch a sack in the Week 1 contest, but he was a strong presence on the edge against the Rams' run and pass game. The 28-year-old played 59 percent of the defensive snaps, in line with the other starters on the team's defensive line.
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49ers' Nick Bosa: Expected to play Week 1
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San Francisco defensive coordinator Raheem Morris said Monday that Bosa (knee) will play in Thursday's Week 1 matchup against the Rams, Harrison Rich of the San Francisco Chronicle reports.
Bosa has been continuing the rehab on his right knee after undergoing surgery for a torn ACL last September. The star edge rusher traveled with the 49ers to Melbourne, Australia ahead of Thursday's season opener, but his status had been uncertain entering the week. Morris seemed to confirm that Bosa will play while speaking to reporters in Melbourne on Tuesday (local time), saying of Bosa, "Oh, he's going out there. Whatever you want to say, he's going. He'll be there. We're not hiding that."
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49ers' Nick Bosa: Progresses in recovery
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Bosa's (knee) tendinitis symptoms have been subsiding recently, David Lombardi of SFStandard.com reports.
Bosa continues to work toward a return to the field. The 49ers' defense is in desperate need of the star pass rusher's services after preseason game and joint practice failures on the defensive line. The 28-year-old is still considered week-to-week, with coach Kyle Shanahan saying Tuesday that the star is doing well. Bosa has a floor of 9.0 sacks when healthy, so the team will likely do whatever it takes to ensure he's on the field for the regular season.
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49ers' Nick Bosa: Still dealing with soreness
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Bosa (knee) did not participate during the 49ers' training camp practice Monday, Eric Branch of the San Francisco Chronicle reports.
Bosa has now missed four straight training camp practices due to soreness. San Francisco will likely take a cautious approach in bringing the five-time Pro Bowler back up to full speed, given the team's financial investment in him and the fact that it already has a number of injuries to other players in the front seven.
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49ers' Nick Bosa: Officially sent to IR
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The 49ers placed Bosa (knee) on injured reserve Thursday.
Bosa torę his ACL in last Sunday's win over the Cardinals and will miss the remainder of the season. He's slated to undergo surgery Friday, as the star edge rusher suffered a clean tear of the ACL, paving the way for a relatively straightforward rehab process. Bosa turns 28 years old next month and will wrap up the 2025 campaign with 17 tackles (nine solo), including 2.0 sacks, two forced fumbles and one fumble recovery across three regular-season contests. He was on his way to yet another big season on the stat sheet.
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49ers' Nick Bosa: Season-ending injury feared
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Bosa (knee) is feared to have suffered a season-ending ACL tear during Sunday's win over the Cardinals, Adam Schefter of ESPN reports.
Bosa appears set for surgery, despite initial reports indicating that he had avoided an ACL tear after being forced out of Sunday's 16-15 win over the Cardinals. The 49ers haven't yet officially confirmed the severity of Bosa's injury, but expectations are that the team will have to proceed forward without the the five-time Pro Bowler. Schefter reports that Bosa suffered a "clean" ACL tear, which will at least provide him a clearer rehab process as he works to get fully healthy for the 2026 season.
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49ers' Nick Bosa: No ACL tear
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Bosa (knee) did not tear his ACL when he got injured during Sunday's 16-15 win over the Cardinals, Matt Barrows of The Athletic reports.
The defensive end suffered the injury in the first quarter and did not return. After the win, San Francisco coach Kyle Shanahan said tests would be needed to determine a diagnosis, per Barrows. The five-time Pro Bowler has 17 tackles (nine solo), including 2.0 sacks, two forced fumbles and a fumble recovery on the young season.
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49ers' Nick Bosa: Exits with knee injury
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Bosa is questionable to return to Sunday's game against the Cardinals due to a knee injury, Nick Wagoner of ESPN.com reports.
Bosa appeared to suffer a knee injury late in the first quarter after being hit hard on a double team, per Wagoner. Bosa was in the blue medical tent before departing for the locker room, where he will be evaluated to determine whether he can return to Sunday's game. Yetur Gross-Matos, Sam Okuayinonu and Bryce Huff will see more snaps at defensive end for as long as Bosa is out of the game.
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49ers' Nick Bosa: Strip sack in win
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Bosa recorded six solo tackles, including 1.0 sacks, while also adding a forced fumble and a fumble recovery in Sunday's 17-13 win over the Seahawks.
Bosa was a major problem for Seattle, recording a strip sack of Sam Darnold in fourth quarter, recovering the fumble and effectively ending the game. The defensive end has registered at least 9.0 sacks in each of the last four seasons and five of his six total campaigns in the NFL, and he has now picked up where he left off to open 2025.
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49ers' Nick Bosa: Practicing in limited capacity
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Bosa (neck) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
Bosa was held out of practice prior to sitting out of the 49ers' second preseason game at Las Vegas with neck soreness, and it still appears to be ailing him ahead of Saturday's preseason game versus the Chargers. As long as he's still sidelined, Sam Okuayinonu will be a contender for first-team reps on the edge.
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49ers' Nick Bosa: Past knee injury
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Bosa (knee) has no injury designation ahead of Sunday's matchup against the Cardinals, Bo Brack of GoPHNX.com reports.
Bosa appears to have recovered from his knee injury in time to suit up Sunday, as he began the 49ers' week of practice with consecutive DNPs before upgrading to a full session Friday. The All-Pro defensive end has appeared in 13 games this season, recording 52 total tackles, including 9.0 sacks, one interception and one forced fumble. With Bosa back at full health, he's expected to wreak havoc on the Cardinals' offensive line and cause problems for Kyler Murray in Week 18.
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49ers' Nick Bosa: Could suit up Sunday
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Bosa (hip/oblique) is listed as questionable ahead of Sunday's matchup against the Dolphins, Matt Maiocco of NBC Sports Bay Area reports.
Bosa appeared to be trending toward not playing in Sunday's contest after downgrading from a limited practice session Wednesday to a DNP on Thursday. The Ohio State product then practiced in a limited capacity again Friday, giving himself a chance to take the field Week 16. If he's unable to play through his hip and oblique injuries Sunday, Robert Beal (ankle, questionable) or Yetur Gross-Matos will likely start opposite Leonard Floyd.
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49ers' Nick Bosa: Misses practice Thursday
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Bosa (oblique/hip) was a non-participant at the 49ers' practice Thursday, Matt Maiocco of NBC Sports Bay Area reports.
Bosa was able to participate in a limited capacity to open the week Wednesday, taking a step backwards in his activity level just a day later. With the 49ers unlikely to make the postseason, the team will likely be very conservative with their superstar edge rusher. If Bosa can't go in Week 16, Yetur Gross-Matos and Robert Beal would stand to see an increase in workload Sunday versus the Dolphins.
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49ers' Nick Bosa: Limited to open week
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Bosa (oblique/hip) was a limited participant in Wednesday's practice.
Bosa returned from a three-game absence to play in the 49ers' Week 15 loss to the Rams this past Thursday, finishing with four tackles (two solo) while playing 47 defensive snaps. He should be able to play against the Dolphins on Sunday unless he downgrades to a DNP over the next two days.
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49ers' Nick Bosa: Active Thursday
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Bosa (oblique/hip) is active for Thursday night's matchup with the Rams, Lindsey Pallares of the 49ers' official site reports.
This ends a three-game absence for the four-time Pro Bowler and 2022 NFL Defensive Player of the Year, who accumulated 36 tackles (24 solo), including 7.0 sacks, an interception, a forced fumble and a fumble recovery in his first 10 games of 2024. Bosa was listed as a non-participant on the 49ers' first two practice reports of the week and a limited participant Wednesday, so his snap count in Thursday's game will be worth monitoring.
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49ers' Nick Bosa: Estimated as DNP
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Bosa (oblique) was estimated as a non-participant at Monday's practice, Nick Wagoner of ESPN.com reports.
Bosa has been sidelined for the 49ers' last three games due to a left oblique injury that he aggravated in Week 11 against the Seahawks. Although he is considered day-to-day heading into Thursday's game against the Rams, Bosa hasn't been able to participate in practice since the injury, and he would be a longshot to play unless he returns to practice Tuesday or Wednesday.
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49ers' Nick Bosa: Ruled out for Week 14
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Bosa (oblique) has been ruled out for Sunday's game against the Bears, Matt Barrows of The Athletic reports.
Bosa was unable to practice this week due to a left oblique injury, and he is set to miss his third straight game. Given the 49ers have a short turnaround before their next game against the Rams on Thursday, Dec. 12, it's possible Bosa will be sidelined for a fourth game. Robert Beal and Yetur Gross-Matos will continue to see more defensive snaps due to Bosa's injury.
