Best betting apps, promos, sites for NFL Week 1: How and where to bet on football during the 2025 season
The Week 1 NFL odds are out and football bettors can use NFL promos at the top NFL betting sites and on NFL betting apps
The Philadelphia Eagles will host the Dallas Cowboys in the 2025 NFL Kickoff Game on Thursday, September 4. The latest Week 1 NFL odds list the Eagles as 7-point favorites over the Cowboys, while the over/under is 46. There's another standalone primetime game on Friday night, as the Chiefs (-3, 45.5) will take on the Chargers in Brazil. Other notable games on the Week 1 NFL schedule include Bills (-1.5, 51.5) vs. Ravens on Sunday Night Football, Packers (-1.5, 49) vs. Lions at 4:25 p.m. ET on Sunday and Jets (+3, 38) vs. Steelers in the Aaron Rodgers Bowl at 1 p.m. ET on Sunday.
Now that the 2025 NFL season is finally here and there are plenty of NFL betting opportunities in Week 1, allowing you to scour the NFL odds from the best betting sites and apps. Here's a closer look at the sportsbook promos that are available for the Week 1 NFL schedule, including instructions on how to claim each offer.
Where to bet on Week 1 NFL games
The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings is offering $300 in bonus bets in addition to more than $200 off NFL Sunday Ticket for the upcoming season. bet365 is offering new users either $200 in bonus bets with the placement of a $5+ bet, or up to a $1,000 first bet safety net. The FanDuel's latest promo code offers new users $300 in bonus bets if their first bet of at least $5 wins.
Both the BetMGM bonus code and Fanatics Sportsbook promo code provide bonus bets, but only if your first bet loses. New users at Fanatics have the ability to get 20+ $100 No Sweat Bets in FanCash if your first football bet loses on every Game Day from Aug. 23 to October. Meanwhile, the BetMGM bonus code CBSSPORTS awards new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in New Jersey, West Virginia, Pennsylvania or Michigan can get a different promotion and receive $150 in bonus bets if you win your first bet of $10 or more.
The Caesars Sportsbook promo code is completely different than the others, offering profit boosts instead of bonus bets. After placing a wager of $1 or more, you receive 20 100% profit boost tokens.
Bettors can use any of these promotions for any game on the Week 1 NFL schedule, which begins Thursday, Sept. 4 with Eagles vs. Cowboys.
Week 1 NFL betting preview, picks
All 32 teams will be in action between Thursday and Monday to open the 2025 NFL season and the Week 1 NFL schedule is highlighted by primetime games on Thursday, Friday, Sunday and Monday. There are also nine divisional rivalry matchups, with the week bookended by Cowboys vs. Eagles in the NFC East and Bears vs. Vikings in the NFC North. Here's a look at a few of the SportsLine Projection Model's Week 1 NFL best bets:
Jacksonville Jaguars (-3) vs. Carolina Panthers | 1 p.m. ET | Sunday, Sept. 7
Doug Pederson was fired after a 4-13 season and now former Buccaneers offensive coordinator Liam Coen takes over as head coach. Coen played a big role in revitalizing former No. 1 overall pick Baker Mayfield's career in Tampa Bay and now he'll hope to help develop former No. 1 overall pick Trevor Lawrence in Jacksonville. Brian Thomas Jr. is an emerging No. 1 receiver and Travis Hunter's playmaking ability should improve the Jaguars on both sides of the ball. In a weakened AFC South, Jacksonville has the potential to get back into the mix quickly while Carolina is still trying to rebuild its roster and decide if Bryce Young is their long-term starter at quarterback all at once. The model says Jacksonville covers in 56% of simulations.
Seattle Seahawks money line (+114) vs. San Francisco 49ers | 4:05 p.m. ET | Sunday, Sept. 7
The Seahawks traded Geno Smith to the Las Vegas Raiders this offseason and then signed Sam Darnold in free agency coming off a career year in Minnesota. Seattle also reworked its receiving corps by letting Tyler Lockett walk in free agency, trading DK Metcalf to the Steelers and signing Cooper Kupp in free agency. However, Mike Macdonald did have the No. 11 scoring defense in 2024 (his first season at the helm) and that unit should be improved after the offseason addition of four-time Pro Bowler DeMarcus Lawrence. Meanwhile, the 49ers battled major injury issues throughout the 2024 season and those concerns linger with Brandon Aiyuk still recovering from an ACL tear and several other key players ailing throughout training camp. The model says Seattle wins outright in 57% of simulations.
Over 41.5 points: Denver Broncos vs. Tennessee Titans | 4:05 p.m. ET | Sunday, Sept. 7
Sean Payton lifted the Broncos from five wins to eight wins in his first season and then a revelatory rookie season from Bo Nix helped lift Denver to 10 wins and a playoff appearance in 2024. Now the offense should be even better in 2025 after adding Evan Engram at tight end and revamping the running game with J.K. Dobbins and second-round pick RJ Harvey. Meanwhile, the Tennessee offense will be hoping to get a similar lift as what Denver experienced with No. 1 overall pick Cam Ward taking over at starting quarterback. Ward has veteran receivers to work in Calvin Ridley, Tyler Lockett and Van Jefferson and this should be a more competent group offensively if Ward's playmaking ability show through. The model predicts the over hits in 60% of simulations.
Responsible gaming
Practicing responsible gaming is paramount, which is why all the top sportsbooks have tools and resources available on their apps and websites, including time and wager limits, voluntary self-exclusion options, and more. Several are equipped with live 24/7 chat support, and all offer links and phone numbers for local and national problem gambling helplines. If you or someone you know is dealing with a gambling problem, please reach out to trained professionals such as the Problem Gambling Help Network at 1-800-GAMBLER.
