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Teagan Quitoriano TE | ARI
Cardinals' Teagan Quitoriano: Scores pair of touchdowns in blowout loss
Quitoriano caught both of his targets for 15 yards and two touchdowns during Sunday's 45-21 loss to Detroit.
Quitoriano entered Sunday having recorded just two receptions since the beginning of the 2023 campaign. The tight end made the most of his two chances in Week 5, reeling in a two-yard touchdown pass from Jacoby Brissett in the first quarter before later connecting with the quarterback again for a 13-yard score in the third quarter. Quitoriano's performance figures to be an anomaly, and he carries no fantasy value moving forward.
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Zach Charbonnet RB | SEA
Seahawks' Zach Charbonnet: Will sit again Week 6
Charbonnet (knee) won't be activated from the reserve/PUP list ahead of Thursday's game versus the Broncos, Seahawks coach Mike Macdonald said after Sunday's 32-29 loss to the 49ers, Corbin Smith of Emerald City Spectrum reports.
Charbonnet returned to practice leading up to Sunday's loss against the 49ers, opening up a 21-day window for the Seahawks to add him back to the active roster. Seattle dropped to 3-2 with the loss, but the Seahawks are content to continue taking a patient approach with Charbonnet's recovery from a torn ACL rather than trying to rush him back on a short week. Charbonnet's next chance to suit up will come Oct. 25 against the Chiefs, while Emanuel Wilson, George Holani and Velus Jones will continue to hold the fort at running back against the Broncos in the absence of Charbonnet and Jadarian Price (chest), who is on IR until at least Week 8.
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Brock Bowers TE | LV
Raiders' Brock Bowers: Stays productive in tough Week 5 loss
Bowers caught eight of 10 targets for 110 yards and a touchdown in Sunday's 45-17 loss to the Patriots.
He did lose a fumble, but otherwise Bowers was the only Raider to put together a strong performance in the rout, catching a 13-yard TD from Kirk Cousins in the first quarter to tie the game at 7-7 before things got out of hand. The superstar tight end has gotten into the end zone in all three of his games this season and topped 100 yards twice, compiling a 24-312-3 line on 35 targets. Fernando Mendoza saw his first NFL action on Las Vegas' final drive after the team had pulled its starters, including Bowers, so the duo didn't get a chance to start building any chemistry. Bowers will look to keep rolling in a Week 6 clash with the Bills.
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Justin Herbert QB | LAC
Chargers' Justin Herbert: Two more turnovers in Week 5
Herbert completed 14 of 24 passes for 121 yards, one touchdown and one interception, reeled off 54 yards on six carries and fumbled twice (one lost) during Sunday's 23-17 loss to the Broncos.
Herbert's season-low number of pass attempts amounted to by far his lowest yardage total through the air through five contests this season. He also turned over the ball two times, which resulted in two late made field goals for Denver (i.e. the margin of defeat) and bringing his total on the campaign to nine (seven INTs, two lost fumbles). Granted, Herbert was working without WR Quentin Johnston (chest, inactive), while Ladd McConkey (foot) was active but doesn't appear to have played a snap, so the deck was stacked against him versus a tough defense. Herbert's next chance to get right is next Sunday versus the 4-0 Chiefs.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Reaches end zone in victory
Perine rushed 14 times for 68 yards while catching both of his targets for 10 yards and a touchdown during Sunday's 31-24 win over Miami.
Perine surprisingly logged one more carry than starting running back Chase Brown (13) in the contest. Additionally, although he saw two fewer targets than Brown, Perine was able to reach paydirt in the second quarter, reeling in a six-yard touchdown pass from Joe Burrow. Perine remains a highly valuable handcuff option for fantasy managers with Chase Brown on their rosters. Through five games, the 31-year-old has rushed 27 times for 110 yards while reeling in seven of 10 targets for 61 yards and a score.
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Trey McBride TE | ARI
Cardinals' Trey McBride: Busy as usual in Week 5 loss
McBride brought in nine of 10 targets for 66 yards and a touchdown in the Cardinals' 45-21 loss to the Lions on Sunday.
McBride was in the familiar position of leading the Cardinals in receptions and targets, and he was narrowly second to Kendrick Bourne in receiving yards. The star tight end's touchdown reception was also a thing of beauty despite the fact it came when the game was completely out of reach, as McBride somehow secured the pass inbounds after tapping it twice to himself while swarmed by two defenders. McBride already has three nine-catch tallies in the first five games of the season, and he's also opened the campaign with five consecutive double-digit target tallies. McBride already has 42 receptions in 2026, putting him well on pace for a third straight 100-catch season heading into a Week 6 home matchup against the Rams next Sunday.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Musters 39 total yards in Week 5
Hampton turned 14 carries into 33 yards and one target into a six-yard catch during Sunday's 23-17 loss to the Broncos.
Hampton has found room to run in the Chargers' mostly stagnant offense difficult to come by so far this season, averaging 3.7 YPC through five games after going for 4.4 as a rookie in 2025. And on Sunday in particular, he had to contend with fellow RBs Kimani Vidal (nine touches) and Keaton Mitchell (six) mixing into the action a decent amount. Due to ceding those reps to his backfield mates, Hampton's weekly ceiling doesn't appear to be as high as it may have seemed heading into the campaign.
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Amon-Ra St. Brown WR | DET
Lions' Amon-Ra St. Brown: Six catches in Week 5 win
St. Brown secured six of 11 targets for 69 yards and committed two fumbles that remained with Detroit in the Lions' 45-21 win over the Cardinals on Sunday.
St. Brown fell below his usual lofty standards with his numbers, but the star receiver still finished with team-high reception and target totals, while also slotting in as the runner-up in receiving yards. St. Brown remains as integral a component of the Lions' air attack as ever, as he now has back-to-back 11-target games and has already seen 57 passes come his way overall in the first five contests of the campaign. St. Brown has turned those opportunities into a 37-372-5 line, and he'll be looking to snap a two-game touchdown drought when the Lions return to action in a NFC North home clash against the Packers on Sunday, Oct. 25 following a Week 6 bye.
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Kyle Williams WR | NE
Patriots' Kyle Williams: Finds paydirt in blowout win
Williams caught all three of his targets for 91 yards and a touchdown while also adding three kick returns for 71 yards during Sunday's 45-17 win over the Raiders.
Williams led the team in receiving yards during the victory, most notably reeling in a 34-yard touchdown pass from Drake Maye in the second quarter. The wide receiver has now caught five of 10 targets for 135 yards and a touchdown while also compiling 344 yards as a kick returner over five contests to open the 2026 campaign.
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Pat Freiermuth TE | PIT
Steelers' Pat Freiermuth: Finds end zone twice in win over Indy
Freiermuth caught five of seven targets for 44 yards and two touchdowns in Sunday's 34-22 win over the Colts. He added one yard on his lone carry.
The veteran tight end connected with Aaron Rodgers on a one-yard score in the second quarter and a 17-yard strike in the fourth. Freiermuth is up to four touchdowns through five games to begin the season, already matching his total over 17 regular-season contests in 2025, and his 19 catches has him on pace to match the career-high 65 passes he hauled in during 2024. Freiermuth will look to keep rolling in a Week 6 road trip to Tampa Bay.