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DeVonta Smith WR | PHI
Eagles' DeVonta Smith: Could miss multiple games
Smith (hamstring), who has been ruled out for Sunday's game against the Rams, is viewed "at very best, questionable" for the Eagles' Week 5 game versus the Jaguars in London, Mike Garafolo of NFL Network reports.
After he was unable to practice in any fashion during Week 4 while tending to the hamstring injury, Smith looks like he could be in store for a multi-game absence. The Eagles will likely wait and see how Smith fares in practice during the upcoming week before deciding whether he'll make the trip to London. While they are without Smith's services for at least the matchup with the Rams, the Eagles will look to get by with Dontayvion Wicks, Makai Lemon, Darius Cooper and Elijah Moore as their main options at receiver.
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Luke McCaffrey WR | WAS
Commanders' Luke McCaffrey: Inactive for Week 4
McCaffrey (coach's decision) is inactive for Sunday's game against the Colts in London.
McCaffrey suited up for the first time all season in the Commanders' Week 3 win over the Seahawks, but his playing time was contained to special teams. Even with top wideout Terry McLaurin (hamstring) sitting out Sunday, McCaffrey won't be called upon to provide depth at receiver. Washington will go with Stefon Diggs, Antonio Williams, Treylon Burks, Dyami Brown and Jaylin Lane as its available options at the position.
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Darius Slayton WR | IND
Colts' Darius Slayton: Not suiting up Week 4
Slayton (coach's decision) is inactive for Sunday's game against the Commanders in London.
Even though the Colts' depth at wide receiver will be tested in Week 4 with Keenan Allen (groin) inactive and Alec Pierce (heel) out for a second straight game while on injured reserve, Slayton apparently needs more time to get acclimated after signing with Indianapolis on Sept. 21. With Slayton being a healthy scratch, the Colts will proceed with Josh Downs, Laquon Treadwell, Ashton Dulin, Deion Burks, Nick Westbrook-Ikhine and Anthony Gould as their available options at wideout.
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Ashton Dulin WR | IND
Colts' Ashton Dulin: Playing for first time since Week 1
Dulin (ankle) is active for Sunday's game against the Commanders in London.
Though he had been listed as questionable heading into the weekend, Dulin had always appeared likely to put an end to his two-game absence after practicing fully Thursday and Friday. Dulin projects to make his biggest impact on special teams when the Colts are at full strength at receiver, but he'll be needed to handle a depth role on offense Week 4 while fellow wideouts Keenan Allen (groin) and Darius Slayton (coach's decision) are inactive.
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Terry McLaurin WR | WAS
Commanders' Terry McLaurin: Sitting out London game
McLaurin (hamstring) is inactive for Sunday's game against the Colts in London.
McLaurin was added to the Week 4 injury report Friday, taking a questionable tag into the weekend after the hamstring issue resulted in him being limited in the Commanders' final practice. Though the Commanders were initially hopeful that the wideout would be able to play through the injury Sunday, the team ultimately erred on the side of caution and opted to hold McLaurin out for the first time all season. With McLaurin sidelined, the Commanders will be left with Stefon Diggs, Antonio Williams, Treylon Burks and Dyami Brown as their main options at receiver.
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Puka Nacua WR | LAR
Rams' Puka Nacua: No limitations expected in return
Nacua (hip) isn't expected to have limitations on his workload during Sunday's game in Philadelphia, Adam Schefter of ESPN reports.
Having said that, the Rams will keep an eye on Nacua's conditioning once he steps on the field, something that ultimately could impact his snap count, but they're operating under the assumption that he's good for his typical allotment, when healthy. He missed the last two games due to what was listed by the team as a hip issue but head coach Sean McVay termed "soreness in his groin" unrelated to the psoas discomfort that he tended to in training camp. In his only appearance this season in Week 1 versus the 49ers in Melbourne, Australia, Nacua handled 70 percent of the offensive snaps and reeled in five of nine targets for 74 yards.
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Jalen Coker WR | CAR
Panthers' Jalen Coker: Unlikely to play Sunday night
Coker (quadriceps) is unlikely to suit up for Sunday night's game against the Lions, Adam Schefter of ESPN reports.
Coker previously played through an ankle issue in Weeks 2 and 3 before a strained quadriceps caused an early exit from last Sunday's loss at Cleveland. He then followed a DNP on Wednesday with back-to-back limited sessions to cap Week 4 prep, leaving him questionable heading into the weekend. If Coker is listed among the Panthers' inactives Sunday night, the likes of Brycen Tremayne, John Metchie, David Moore and Ja'seem Reed will be the wide receivers available behind clear No. 1 Tetairoa McMillan.
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Mike Evans WR | SF
49ers' Mike Evans: May suit up Sunday
Evans (ribs) has said "he'll do his best to be out there" Sunday against the Broncos, Ian Rapoport of NFL Network reports.
Evans exited in the second quarter of last Sunday's win versus the Cardinals after taking a big hit from Arizona safety Budda Baker and wasn't able to return. Evans then managed just one limited practice Friday before being listed as questionable for Week 4 action. Head coach Kyle Shanahan told Vic Tafur of The Athletic at the end of the week that Evans was lining up to be a game-time decision, and a pregame workout ultimately may determine his availability ahead of a 4:25 p.m. ET kickoff.
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Ladd McConkey WR | LAC
Chargers' Ladd McConkey: Likely to play Sunday
McConkey (foot), who is listed as questionable for Sunday's game at Seattle, is likely to suit up, Ian Rapoport of NFL Network reports.
McConkey was limited at Wednesday's session due to a foot injury and then didn't practice at Thursday, after which he was seen exhibiting a limp, per Kris Rhim of ESPN.com. McConkey again was limited Friday before drawing a questionable tag for Week 4 action. The current health concern isn't considered as serious as the rib issue he dealt with earlier this season, per Rapoport, so he should be good for his usual No. 1 WR role in the Chargers offense Sunday, assuming he's active.
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Zay Flowers WR | BAL
Ravens' Zay Flowers: In line to play Sunday
Flowers (hamstring) is expected to play in Sunday's game against the Titans, Ian Rapoport of NFL Network reports.
Flowers carried a questionable tag into the weekend due to a lingering hamstring issue, but he's slated to suit up in Week 4 for a second straight week. Last Sunday against the Cowboys in Brazil, he handled a 33 percent snap share and hauled in five of six targets) for 84 yards, but per Jeremy Fowler of ESPN.com, Flowers isn't expected to be on a "pitch count" this Sunday, so he appears set for a full workload.