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Andy Isabella WR | SF
Bills' Andy Isabella: Recovers from injury
Isabella (leg) returned to practice Wednesday, Joe Buscaglia of The Athletic reports.
Isabella was able to make a quick recovery after being carted off the field Monday. The 27-year-old is likely facing an uphill battle to make the Bills' final 53-man roster, but his speedy return to the field should keep him in contention for now.
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Josh Downs WR | IND
Colts' Josh Downs: Dealing with high-ankle sprain
Downs suffered a high-ankle sprain during Wednesday's practice, Jeremy Fowler of ESPN.com reports.
Per Fowler, the initial outlook is that Downs could miss about a month, but that's not yet a concrete estimate, as the Colts are currently working to establish a timeline for the receiver's return. In any case, Downs' Week 1 status will be worth monitoring closely, and if he's out or limited early on this season, Adonai Mitchell and Alec Pierce could see added opportunities alongside Michael Pittman.
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Jayden Reed WR | GB
Packers' Jayden Reed: Managing calf injury
Reed won't practice Wednesday due to a calf injury, Wes Hodkiewicz of the Packers' official site reports.
Reed missed the start of training camp due to a toe injury, and the second-year wideout is now dealing with a calf issue. There's not yet any reason to believe that Reed is facing anything too significant, but it could be enough to prevent him from taking the field with Jordan Love and the rest of the starting offense to kick off Saturday's road exhibition matchup against the Browns. Any time Reed spends sidelined will provide a clearer path for Dontayvion Wicks and Bo Melton to take regular reps with the first-team offense.
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Kadarius Toney WR | CLE
Chiefs' Kadarius Toney: Bothered by back tightness
Chiefs head coach Andy Reid said that Toney missed practice Wednesday due to back tightness, Pete Sweeney of ArrowheadPride.com reports.
The oft-injured wide receiver previously missed a few training-camp practices with an ankle injury but mostly has been available this summer. Toney is competing for a depth role and is also likely to get a look as a return man.
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Braxton Berrios WR | NYG
Dolphins' Braxton Berrios: Not practicing due to minor issue
Dolphins head coach Mike McDaniel said Wednesday that Berrios is dealing with a minor, unspecified injury, Marcel Louis-Jacques of ESPN.com reports.
The slot receiver and return specialist didn't practice Wednesday and presumably won't play in Friday's preseason game against the Falcons. Berrios is still expected to be ready well before the start of the regular season.
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Rondale Moore WR | MIN
Falcons' Rondale Moore: Carted off with non-contact injury
Smith was carted off the field at Wednesday's practice due to a non-contact right knee injury, Josh Kendall of The Athletic reports.
Moore's injury caused Wednesday's joint session with the Dolphins to be called early, an indication that he could be dealing with a severe issue. A torn ACL or another major knee injury would be a brutal development for the 2021 second-round pick, who has spent training camp mostly working with the second-string offense and is competing to carve out a role on offense behind top wideouts Drake London and Darnell Mooney. If Moore's injury indeed results in a long-term absence, Ray-Ray McCloud will be left with almost no competition for the No. 3 wide receiver spot.
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Josh Downs WR | IND
Colts' Josh Downs: Severity of ankle injury unknown
Colts head coach Shane Steichen said after Wednesday's practice that he's unsure of the severity of Downs' ankle injury, Kevin Bowen of 107.5 The Fan Indianapolis reports.
Downs reportedly didn't put much weight on his injured leg when he was helped off the field earlier Wednesday. Initial reports were pessimistic, potentially creating a hurdle for a young wide receiver to overcome heading into his second season. Downs recorded a 68-771-2 receiving line on 98 targets last season, mostly working out of the slot after Indianapolis took him 79th overall in the 2023 NFL Draft.
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Brandon Aiyuk WR | SF
49ers' Brandon Aiyuk: New England exits trade talks
The Patriots are no longer exploring a trade for Aiyuk, Adam Schefter of ESPN reports.
Matt Maiocco of NBC Sports Bay Area reports that the Patriots met the 49ers' trade demands and had a large contract offer on the table, but a deal didn't work out because Aiyuk wasn't willing to sign with New England. The Steelers and Browns are now thought to be the main teams pursuing the 26-year-old wideout, with earlier reports suggesting Cleveland might offer wideout Amari Cooper as part of a trade. Pittsburgh wouldn't be able to offer a comparable wide receiver -- assuming George Pickens is off the table -- but might be able to make up the difference with additional draft capital and/or players at other positions. It's also still possible Aiyuk and the 49ers come to an agreement on an extension, although there's certainly some awkwardness involved after months of tense negotiations and now open trade talks.
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Jaylen Waddle WR | DEN
Dolphins' Jaylen Waddle: Dealing with minor injury
Dolphins head coach Mike McDaniel said Wednesday that Waddle is missing practice this week due to a minor, unspecified injury, Marcel Louis-Jacques of ESPN.com reports.
McDaniel made it clear he doesn't consider the injury serious, noting that Waddle and Braxton Berrios are dealing with "minor stuff" and nothing more. The Dolphins are four and a half weeks out from their season opener Sept. 8 against Jacksonville, at which point Waddle should make his first regular-season appearance since signing a three-year, $84.75 million extension in May.
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Puka Nacua WR | LAR
Rams' Puka Nacua: Should be fine for Week 1
Head coach Sean McVay said Tuesday that there's "no threat" of Nacua (knee) missing the Rams' Week 1 game at Detroit, Sarah Barshop of ESPN.com repors. "Really just had a little bit of a bursa sac, kind of burst it," McVay said of Nacua's knee injury. "And it's just going to be week-to-week with him. Nothing serious, nothing structurally. He'll be in good shape, and he'll recover and we'll be ready to go; no threat of anything for Detroit."
Nacua made an early exit from Sunday's joint practice with the Chargers -- exactly five weeks before the Rams' season opener -- after his knee got "banged up" on a touchdown reception, per McVay. The 23-year-old will be sidelined for practice for at least a couple weeks but apparently is expected back in time for Week 1 prep.