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Emanuel Wilson RB | SEA
Seahawks' Emanuel Wilson: Notches 21 carries in victory
Wilson rushed 21 times for 92 yards and failed to catch his only target in Sunday's 31-7 win over Arizona.
Wilson stepped into a larger workload Week 2, partially due to rookie running back Jadarian Price exiting the game with a chest injury in the fourth quarter. The 92 rushing yards were Wilson's highest total since he notched 107 yards and two scores on 28 totes in Week 12 of the 2025 campaign while with the Packers. Wilson could handle the lion's share of touches in the backfield against the Commanders in Week 3 if Price is forced to miss the contest.
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De'Von Achane RB | MIA
Dolphins' De'Von Achane: Inefficient start against stacked fronts
Achane rushed 20 times for 74 yards while catching three of six targets for 19 yards in Sunday's 35-13 loss to the 49ers.
Achane racked up 23 touches after touching the ball 11 times in Week 1, but the speedster has struggled to find running room while consistently facing stacked boxes. He is averaging a meager 3.5 yards per rushing attempt heading into a Week 3 home game against the Chiefs, which is a departure from Achane's excellent efficiency in previous seasons, as he averaged 5.7 yards per carry last season and has a career mark of 5.6 YPC. Defenses are daring Malik Willis and Miami's underwhelming wide-receiver room to beat them, and Miami's offense hasn't been up to the task during the team's 0-2 start.
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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Scores twice to reach 100 career TDs
McCaffrey rushed 10 times for 23 yards and two touchdowns while catching both of his targets for 43 yards in Sunday's 35-13 win over the Dolphins.
McCaffrey opened the scoring with a one-yard touchdown run in the first quarter and added another one-yard touchdown run in the third quarter. The two-touchdown performance brought McCaffrey's career regular-season touchdown total up to 100. Exactly half of those touchdowns have come with the 49ers, as McCaffrey joins Marshall Faulk and Randy Moss as the only players to score at least 50 touchdowns apiece for multiple teams, per ESPN Insights. McCaffrey should continue to contribute as both a runner and a pass catcher in Week 3 against the Cardinals.
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Ashton Jeanty RB | LV
Raiders' Ashton Jeanty: Handles 25 touches in Week 2 upset
Jeanty rushed 21 times for 48 yards and brought in four of seven targets for 15 yards in the Raiders' 26-14 win over the Chargers on Sunday.
Jeanty was the unquestioned leader of the Raiders' ground attack once again, and although he had to scratch and claw for every yard, the second-year back helped keep the Bolts' defense honest. Jeanty also finished second in receptions and tied for the team lead in targets, underscoring how central he is to what Las Vegas does on offense. Jeanty and his teammates will be gunning for a third consecutive victory to open the season when they tangle with the equally surprising Saints on the road next Sunday.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Mixed performance in Week 2 loss
Hampton rushed 23 times for 94 yards and a touchdown and brought in both targets for 21 yards in the Chargers' 26-14 loss to the Raiders on Sunday. He also lost a fumble.
Hampton put together a perfectly useful fantasy performance in the Chargers' alarming upset loss, spearheading Los Angeles' ground attack while handling a workhorse role. Hampton added a one-yard touchdown run in the second quarter, but his lost fumble in Raiders territory with 3:52 remaining in the game and the Bolts trying to erase a three-point deficit was a back-breaker, as it led to Las Vegas' game-clinching touchdown. Hampton has a rushing touchdown in each of the first two games of the new season but has a pair of lost fumbles as well. Nevertheless, the talented back will remain in the lead role for a Week 3 road showdown against the Bills next Sunday, a critical early-season contest for Jim Harbaugh's squad.
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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Held in check versus Seattle
Love rushed nine times for 29 yards while catching all three of his targets for 16 yards in Sunday's 31-7 loss to Seattle.
Love and the rest of the Cardinals' offense mustered only a combined 151 total yards Sunday. The running back was able to reel in multiple catches for the second straight week to open the regular season, and he saw 12 touches to Tyler Allgeier's seven in the contest. Arizona will have another tough test with a road matchup against the 49ers (2-0) in Week 3, but Love figures to continue to separate from the pack as the Cardinals' clear No. 1 option at running back moving forward.
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Jadarian Price RB | SEA
Seahawks' Jadarian Price: X-rays on chest negative
Seahawks head coach Mike Macdonald said after Sunday's 31-7 win over the Cardinals that X-rays came back negative on Price's chest injury, Curtis Crabtree of Fox 13 Seattle reports.
Price didn't check back in after being deemed questionable to return in the fourth quarter, though he managed to rejoin his teammates on the sideline, per Bob Condotta of The Seattle Times. Emanuel Wilson finished the game with a team-high 92 rushing yards on 21 carries, while Price posted 13 carries for 52 yards and caught one of two targets for eight yards prior to exiting. The Seahawks will post their next practice report Wednesday, when it will be known whether Price is operating with any limitations as the Seahawks begin prepping for a Week 3 road game at Washington.
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Tony Pollard RB | TEN
Titans' Tony Pollard: Modest numbers in Sunday's loss
Pollard carried the ball 14 times for 64 yards and caught his only target for one yard in Sunday's 24-20 loss to the Eagles.
The veteran RB had 15 touches to Tyjae Spears' nine, as Pollard continues to pace the Titans' backfield in volume. Spears amassed 70 scrimmage yards to Pollard's 65, however, as neither back has made much of a case in the early going to take over the clear lead role. Pollard will look for his first touchdown of the season in a Week 3 road tilt against the Giants.
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Tank Bigsby RB | PHI
Eagles' Tank Bigsby: Gets into end zone in Sunday's win
Bigsby carried the ball 13 times for 33 yards and a touchdown in Sunday's 24-20 win over the Titans. He also caught both his targets for five yards.
The fourth-year RB got the Eagles on the board in the second quarter with a two-yard TD plunge, and Bigsby led the backfield in totes and rushing yards after Saquon Barkley picked up a stinger on the first play from scrimmage. Barkley was able to return after halftime, but he'll be sent for further testing and isn't guaranteed to be 100 percent for a Week 3 road trip to Chicago. If he's sidelined or has his workload scaled back, Bigsby would be poised to benefit.
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DJ Giddens RB | IND
Colts' DJ Giddens: Unavailable for Week 2
Giddens (knee) is inactive for Sunday night's matchup with the Chiefs.
Giddens was inactive Week 1 as a healthy scratch, and he will now be forced to miss the team's second contest of the year as he nurses an apparent knee injury. In Giddens' absence, Seth McGowan will operate as the team's primary reserve option behind starting running back Jonathan Taylor versus Kansas City.