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Melvin Gordon RB | BAL
Chargers' Melvin Gordon: Touchdown binge continues in win
Gordon rushed for 132 yards and three touchdowns on 18 carries while catching two of four targets for 18 yards in Sunday's 38-14 win over Cleveland.
Gordon opened the scoring with a four-yard rushing touchdown, then added scores from 10 and 11 yards out in the third quarter. He's been a touchdown machine this season, with six on the ground and three more through the air. Gordon should be treated as an RB1 in all matchups, including the upcoming Week 7 home tilt against Tennessee.
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James Conner RB | ARI
Steelers' James Conner: Delivers big game before Bell's return
Conner rushed 19 times for 111 yards and two touchdowns while catching four of seven targets for 18 yards in Sunday's 28-21 win over the Bengals.
Conner scored a pair of one-yard touchdowns in the second quarter. He came less than a yard short of the goal line on a 25-yard run in the third and was subsequently stuffed on two attempts, so Pittsburgh was forced to settle for a field goal. With Le'Veon Bell due back during Pittsburgh's Week 7 bye, questions loom over Conner's workload moving forward. Chances are his role will be limited if Bell's healthy.
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Christian McCaffrey RB | SF
Panthers' Christian McCaffrey: Neutralized in loss to Washington
McCaffrey managed only 20 rushing yards on eight attempts, but added seven receptions for 46 yards in a 23-17 loss to the Redskins on Sunday.
An underrated Washington front seven held McCaffrey to his lowest offensive output (66 total yards) in an otherwise stellar sophomore campaign. Game flow did not facilitate a heavy workload on the ground for the second-year back, as Carolina fell into a double-digit deficit in the first half and was forced to air it out in an ultimately insufficient effort to mount a comeback. Week 7 brings an NFC heavyweight showdown with Philadelphia, and an Eagles defense that hadn't allowed a running back to exceed 42 rushing yards this season until Saquon Barkley put up 130 yards on the ground Thursday night.
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Samaje Perine RB | CIN
Redskins' Samaje Perine: Active for first time this season
Perine is active for Sunday's contest versus the Panthers, Kareem Copeland of The Washington Post reports.
For the first time this season, Perine cracked the 46-man gameday roster. The opportunity arose with Chris Thompson (ribs/knee) inactive, but Adrian Peterson is still on hand to handle the bulk of the carries while Kapri Bibbs is the best bet to act as the Thompson fill-in. If he sees the field Sunday, Perine's track record includes 3.4 YPC and 22 catches (on 24 targets) in 16 games during the 2017 campaign.
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Latavius Murray RB | BUF
Vikings' Latavius Murray: Gets start at running back
Murray will start at running back with Dalvin Cook (hamstring) inactive for Sunday's game against Arizona.
Even though Cook has missed two games due to injury and has been limited to 18 snaps in another one, Murray has yet to make a major impact. Murray has totaled just 106 yards on 30 carries (3.5 per attempt) and nine receptions for 60 yards while failing to find the end zone through five weeks. Still, that could change against a struggling Arizona defense that's 31st in rushing yards allowed per game.
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Active Week 6
Edmonds (back) is officially active for Sunday's game at Minnesota.
Edmonds received the questionable tag after being added to the injury report Friday, but he's well enough to give it a go Sunday. The 22-year-old should serve his usual role behind workhorse David Johnson, who has dominated the touches out of Arizona's backfield.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Inactive Week 6
Cook (hamstring) is inactive for Sunday's game against the Cardinals, Adam Schefter of ESPN reports.
Although Cook was expected to return, his hamstring didn't react well to a pregame warmup. As such, Latavius Murray should handle the bulk of the running back workload Sunday, though Mike Boone and Roc Thomas could also get in on the act.
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Latavius Murray RB | BUF
Vikings' Latavius Murray: Could split work with Cook
Murray could work in a timeshare with Dalvin Cook (hamstring) during Sunday's game against the Cardinals, as Cook is only expected to see the field for around 20-to-25 plays, Ben Goessling of the Minneapolis Star Tribune reports.
Adam Schefter of ESPN essentially validated Goessling's report, relaying that Cook would likely only be available for about half the Vikings' offensive snaps, if that. While Cook noted after a limited practice Friday that his injured hamstring is feeling better, he acknowledged he's not quite 100 percent. As a result, the Vikings seem content to pick their spots carefully for Cook this week, paving the way for Murray to maintain a healthy snap count of his own. Even though Cook has missed two games due to injury and limited to 18 snaps in another one, Murray has yet to make a major impact. Murray has totaled just 106 yards on 30 carries (3.5 per attempt) and nine receptions for 60 yards while failing to find the end zone through five weeks.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: On snap count Sunday
The Vikings plan on Cook (hamstring) playing Sunday against the Cardinals, but he'll likely be limited to around 20-to-25 offensive snaps, Ben Goessling of the Minneapolis Star Tribune reports.
Cook, who was officially listed as questionable heading into the weekend, sent mixed signals about his health during recent practices. After opening the week with a limited practice Wednesday, he logged a full session Thursday before being limited again Friday. Adam Schefter of ESPN confirmed that while Cook isn't 100 percent recovered from the hamstring strain that sidelined him against the Eagles last week, the second-year back will be ready to handle a restricted role Sunday. Expect Cook to split work in the backfield with Latavius Murray in fairly even fashion.
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Matt Breida RB | SF
49ers' Matt Breida: Questionable for Monday
Breida (shoulder/ankle) is listed as questionable for Monday's game against the Packers and will have his availability decided on game day, Matt Barrows of The Athletic reports.
Breida was sidelined at practice to start the week but put in a limited session Saturday to keep alive his prospects of playing Monday. Earlier in the week the team considered the 23-year-old as doubtful, so he's at least trending in the right direction. Coach Kyle Shanahan said the team would elevate a running back from the practice squad if Breida is ultimately unable to suit up, which would leave Alfred Morris and Raheem Mostert to handle backfield duties for the 49ers.