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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Expected to play Saturday
Gordon (shoulder) is expected to suit up for Saturday's game against the Bills, James Palmer of NFL Network reports.
Gordon and backfield mate Phillip Lindsay (hip) are both expected to play versus the Bills, an eventuality which should result in the duo splitting carries fairly evenly, as usual. An official word on Denver's backfield will come when the team's inactives are released ahead of Saturday's 4:30 ET kickoff.
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Damien Harris RB | BUF
Patriots' Damien Harris: Officially ruled out
Harris (ankle) was downgraded from questionable and will not play Sunday against the Dolphins.
The news means Sony Michel will step back into the starting lineup as the primary two-down back, with James White (foot) mixing in as a pass catcher and J.J. Taylor (quadriceps) operating as the spellback in both situations. Harris, who popped up on the injury report Thursday with an ankle injury after missing time the previous week with a back issue, will aim for a return in Week 16 against the Bills.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: No changes to designation
Coach Zac Taylor said Saturday that Mixon (foot) has not had any changes to his injury designation, Ben Baby of ESPN.com reports.
Taylor declined to reveal whether Mixon has sought a second opinion on his injury, but he at least affirmed that the 24-year-old will not require surgery. Mixon is set to miss his eighth straight contest due to his lingering foot issue, and while it still appears as though he could still come off IR before the end of the season, the Bengals haven't offered anything resembling an official timetable for his return. Giovani Bernard, Trayveon Williams and Samaje Perine will continue to work out of the backfield in the meantime.
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Jason Huntley RB | IND
Eagles' Jason Huntley: Ruled out for Week 15
Huntley (illness) is ruled out for Sunday's game against the Cardinals.
Huntley's ailment will force him to sit out Sunday's contest, but it isn't as though he was a likely candidate to see the field anyway. He's been a healthy scratch since Week 8.
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Travis Homer RB | PIT
Seahawks' Travis Homer: Absence extends another week
Homer (knee) has been ruled out for Sunday's game versus Washington, John Boyle of the Seahawks' official site reports.
Homer is set to miss a fifth straight game. He's displayed no meaningful progress in his recovery, as he last practiced Nov. 18. Chris Carson, Carlos Hyde and DeeJay Dallas will be the team's only running backs in Week 15.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Set up for big game
Kamara is expected to be busy in the passing game Sunday versus Kansas City, playing in a Saints offense with Drew Brees (ribs) at quarterback and Michael Thomas (ankle) out of the lineup, Nick Underhill of NewOrleans.Football reports.
Kamara had a rushing touchdown and seven receptions in last week's loss to the Eagles, but he otherwise put up mediocre numbers with Taysom Hill at quarterback over the past month. Kamara averaged 14.2 PPR points in Hill's four starts, down from 27.4 per game in nine appearances with Brees under center. Kamara was even better during a six-game stretch when the Saints had Brees but not Thomas in the lineup, averaging 28.7 PPR points and 9.7 targets. The dual-threat back returns to high-end RB1 status now that Brees is back, facing a Chiefs defense that's given up the eighth-most rushing yards (102.7 per game) and eighth-most receiving yards (67.6) to running backs.
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Ezekiel Elliott RB | LAC
Cowboys' Ezekiel Elliott: On track to play, despite absences
Elliott (calf) is expected to play in Sunday's game against the 49ers, despite being listed as questionable after missing practice throughout the week, Jon Machota of The Athletic reports.
Coach Mike McCarthy admitted earlier Friday that Elliott is a little behind where he was at the same point last week. Even so, McCarthy told Michael Gehlken of The Dallas Morning News that "all things look like [Elliott]'s going to play" in Sunday's game against the 49ers. If anything goes wrong before the 1 p.m. ET kickoff, Tony Pollard would be in line for a huge workload in a game where the losing team won't have a realistic path to the playoffs.
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Kenyan Drake RB | GB
Cardinals' Kenyan Drake: Could benefit if Edmonds sits
Drake will likely be in store for a heavier workload Sunday against the Eagles in the event Chase Edmonds (ankle) -- who is considered a game-day decision -- isn't available to play, Kyle Odegard of the Cardinals' official site reports.
When both Drake and Edmonds have been available this season, the Cardinals have favored a two-pronged approach to the backfield, with the former serving as the team's top ballcarrier and the latter representing the preferred pass-catching option. Edmonds' balky ankle may force the Cardinals to deviate from that plan, however, potentially opening the door for Drake to serve as a true bellcow for the first time all season. If that's the case, Drake should have a clear path to 20-plus touches, as the Cardinals' other depth options at the position -- Jonathan Ward, Eno Benjamin and practice-squad player D.J. Foster -- have combined to play just eight offensive snaps this season and don't appear to be serious threats to steal work. Those contemplating using Drake in DFS contests or in season-long leagues will want to keep an eye on Edmonds' status, which should gain clarity when Arizona releases its inactive list 90 minutes prior to Sunday's 4:05 p.m. ET kickoff.
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Derrick Henry RB | BAL
Titans' Derrick Henry: Cleared to play
Henry (non-injury-related) doesn't carry a designation for Sunday's game against the Lions after practicing fully Friday,Terry McCormick of TitanInsider.com reports.
Henry was added to the Titans' practice report Thursday after logging a limited session, but he faced no restrictions Friday. That paves the way for Henry to headline Tennessee's backfield this week versus a beatable Detroit run defense that has allowed an average of 132.8 rushing yards per game to date.