Edmonds didn't practice Wednesday due to a shoulder issue, Josh Weinfuss of ESPN.com reports.
Both Edmonds and James Conner were listed as non-participants, but the latter's absence was attributed to personal reasons. Edmonds wasn't often tasked with significant workloads during his first three seasons in the league, but he's logged at least 60 percent of the offensive snaps in each of the Cardinals' four games en route to 63 touches for 395 yards. The elevated reps may be to blame for his current injury, but he'll look to get past it by week's end in order to play Sunday against the 49ers.