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Devin Singletary RB | NYG
Bills' Devin Singletary: Breaks off 51-yard TD run
Singletary ran for 68 yards and a touchdown on eight carries, corralling all three of his targets for 16 yards during Saturday's 48-19 win against the Broncos.
Singletary led the Bills' running back committee with 39 snaps, but Zack Moss paced the team in both carries (13) and rushing yardage (81) during a dominant road win. A 51-yard TD run with 1:40 remaining in regulation salvaged a solid fantasy day from Singletary, simultaneously providing the back with his first rushing score since Week 4. He's been held to single-digit carries in consecutive outings, but he'll get a chance to build off the explosive late-game contribution next week when the Bills take on the Patriots' No. 23 rush defense.
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Christian McCaffrey RB | SF
Panthers' Christian McCaffrey: Officially inactive
McCaffrey (thigh) is inactive for Saturday's game against the Packers.
McCaffrey is thus in line to miss a fifth consecutive contest and his 11th overall this season. In his absence, Mike Davis will continue to head the Panthers' backfield Saturday. Per David Newton of ESPN.com, coach Matt Rhule hopes that McCaffrey can play next weekend against Washington.
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Royce Freeman RB | CHI
Broncos' Royce Freeman: Injures hip Saturday
Freeman (hip) is questionable to return to Saturday's game against the Bills, Kyle Newman of The Denver Post reports.
Freeman was only handling a reserve role with both Melvin Gordon and Phillip Lindsay active Saturday, so his potential absence won't have a huge impact on Denver's offense. However, the Broncos only have three running backs active Saturday, and the team will be a bit short on depth if Freeman can't return.
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La'Mical Perine RB | PIT
Jets' La'Mical Perine: Won't return Week 15
Perine (ankle) will not be activated from injured reserve Saturday, Rich Cimini of ESPN.com reports.
Perine will miss a fourth straight game due to his high-ankle sprain, setting the stage for Frank Gore, Ty Johnson and Josh Adams to handle New York's backfield reps against the Rams. If Perine can return Week 16, coach Adam Gase will likely deploy him in a committee.
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Christian McCaffrey RB | SF
Panthers' Christian McCaffrey: Likely to be ruled out
McCaffrey (thigh), who is still officially listed as doubtful, will not play Saturday against the Packers, Adam Schefter of ESPN reports.
This was hardly a surprise to anyone, but it reaffirms the lead role will once again belong to Mike Davis, this time in a juicy matchup against the susceptible Packers run defense. It's worth noting the Panthers have not officially downgraded McCaffrey, but it certainly appears to be trending in that direction. Schefter suggested McCaffrey still wants to play at some point this season, but with just two games left to go and the Panthers out of the playoff race, it's possible the 24-year-old could be shut down for the rest of the season.
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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Comes off PUP list
The Seahawks activated Penny (knee) from the PUP list Saturday, Curtis Crabtree of Sports Radio 950 KJR Seattle reports.
Coach Pete Carroll said earlier this week that Penny, who returned to practice Wednesday for the first time since tearing his ACL last season, is expected to suit up for Sunday's home game against Washington. The 2018 first-round pick hasn't appeared in NFL action in over a year, and he's only had the benefit of a few days of practice, so the Seahawks could opt to ease him back into a rotation with Carlos Hyde and Chris Carson.
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James Conner RB | ARI
Steelers' James Conner: Questionable for Monday
Conner (quad) is listed as questionable for Monday's game against the Bengals, Adam Caplan of SiriusXM NFL Radio reports.
Conner was listed as a limited participant in practice for a second consecutive day Saturday, opening up the possibility the fourth-year back could be able to play against the Bengals in Monday's 8:15 p.m. ET tilt. Conner was hardly effective in the previous meeting with Cincinnati in Week 10 (13 carries for 36 yards), so fantasy managers may just want err on the side of caution, especially given the nature of the 25-year-old's injury and the timing of the Steelers' Week 15 kickoff.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Suits up Saturday
Gordon (shoulder) is listed as active for Saturday afternoon's game against the Bills.
As is backfield mate Phillip Lindsay (hip). The stage is thus set for Gordon -- who logged 13 carries for 68 yards and three catches for 23 yards in Denver's Week 14 triumph over the Panthers -- and Lindsay (11 carries for 24 yards, two catches for seven yards) to continue to work in a timeshare on the ground Saturday. That said, Gordon's been more involved as a pass catcher this season and has notched seven TDs (in 12 games) to Lindsay's one (in 10 contests). The duo will take aim at a surging Buffalo defense that held Pittsburgh's lead back, James Conner, to 10 carries for 18 yards in a 26-15 win this past Sunday, but overall has still surrendered an average of 119.9 rushing yards per game to date.
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Ezekiel Elliott RB | LAC
Cowboys' Ezekiel Elliott: Still on track to play
Elliott (calf) is still on track to play Sunday despite the call-up of running back Sewo Olonilua, Michael Gehlken of The Dallas Morning News reports.
It's worth noting the last time Olonilua was elevated to the active roster in Week 9, Elliott was essentially a game-time decision, but the star back did manage to play and still saw his usual workload. Coach Mike McCarthy has continually reinforced the notion Elliott will be available in Week 15, but fantasy managers should still be actively checking his status ahead of the Sunday 1:00 p.m. ET kickoff.