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Damien Harris RB | BUF
Patriots' Damien Harris: Listed as questionable for Sunday
Harris (hamstring) is listed as questionable for Sunday's game versus the Browns after practicing in a limited capacity Thursday and Friday, Evan Lazar of the Patriots' official site reports.
Per Zack Cox of NESN.com, previous reports indicated that Harris was expected to miss time, but the running back's official designation indicates that he has a chance to suit up this weekend. If, however, Harris ends up out or limited versus Cleveland, Rhamondre Stevenson would be in line for added touches, with Pierre Strong and Kevin Harris -- who was signed off the practice squad Thursday -- in the mix for complementary work.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Good to go Week 6
Perine (abdomen) was a full practice participant Friday and doesn't have a designation for Sunday's game in New Orleans.
As usual, Perine is on track to handle No. 2 duties out of the backfield behind three-down workhorse Joe Mixon. The role hasn't translated to much playing time or consistent touches for Perine, who is averaging just three carries and two receptions per game and hasn't seen the field for more than one-third of the snaps on offense in any of the Bengals' first five contests.
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Keaontay Ingram RB | KC
Cardinals' Keaontay Ingram: Set to debut Week 6
Ingram is expected to make his NFL debut in Sunday's game in Seattle with James Conner (ribs) and Darrel Williams (knee) listed as out for the Week 6 contest, Aaron Wilson of ProFootballNetwork.com reports.
Since he hasn't been a part of the Cardinals' special-teams units this season, Ingram, a sixth-round rookie out of USC, was inactive for each of the team's first five games while Arizona had all of its key running backs available. The losses of Conner and Williams for at least one week will pave the way for Ingram to dress, but the 22-year-old may only play a handful of snaps behind Eno Benjamin, who handled a workhorse role in the Week 5 loss to the Eagles following Conner's departure in the second quarter. The Cardinals will also elevate Corey Clement from the practice squad to provide another depth option behind Benjamin.
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Raheem Mostert RB | LV
Dolphins' Raheem Mostert: Questionable, but expects to play
Mostert (knee) is listed as questionable for Sunday's game against the Vikings after logging limited practices Thursday and Friday, Marcel Louis-Jacques of ESPN.com reports.
Barry Jackson of the Miami Herald relays that the running back said he'll play this weekend, but Mostert's status will still be worth verifying ahead of the 1 p.m. ET kickoff. As long as he's active, look for Mostert to continue to lead the Dolphins' rushing attack in Week 6, after carrying 18 times for 113 yards and a touchdown to go along with one catch for nine yards in Miami's Week 5 loss to the Jets.
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Eno Benjamin RB | NO
Cardinals' Eno Benjamin: Lead-back role awaits Week 6
Benjamin is expected to serve as the Cardinals' lead back Sunday against the Seahawks with head coach Kliff Kingsbury having ruled out both James Conner (ribs) and Darrel Williams (knee) for the Week 6 contest, Alex Weiner of ArizonaSports.com reports.
Meanwhile, rookie sixth-round pick Keaontay Ingram is expected to be active for the first time this season as Benjamin's backup, while Kingsbury confirmed that veteran Corey Clement will be promoted from the practice squad to provide additional depth in the backfield. Kingsbury hasn't tipped his hand regarding how the workload distribution among the three backs will shake out, but the prevailing expectation is that Benjamin will step into Conner's usual three-down role, just as he did when Conner exited last Sunday's win over the Eagles. In his most extensive NFL action to date Week 5, Benjamin played 54 percent of the offensive snaps -- including 94 percent in the second half -- and finished with 53 yards and a touchdown on 11 touches (eight carries, three receptions on four targets). With Kingsbury indicating that Conner isn't a sure bet to make it back for a Thursday night game Week 7 against the Saints, Benjamin could be in store for a multi-game run as the Cardinals' top back.
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Corey Clement RB | ARI
Cardinals' Corey Clement: Getting Week 6 call-up
Head coach Kliff Kingsbury said Friday that Clement will be elevated from the practice squad for the Cardinals' Week 6 game in Seattle, Tyler Drake of ArizonaSports.com reports.
Arizona may wait until Saturday to make Clement's appointment to the roster official, but he'll be on hand Sunday to provide another healthy body out of the backfield with James Conner (ribs) and Darrel Williams (knee) sitting out Week 6 and with Jonathan Ward (hamstring) having recently been moved to injured reserve. Eno Benjamin is expected to step into Conner's usual role as Arizona's lead back, but Clement could serve as a change-of-pace option behind him in addition to contributing on special teams. Rookie sixth-round pick Keaontay Ingram is also on hand and could also have a role in the game plan behind Benjamin.
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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Shuttled to IR
Seattle placed Penny (ankle/fibula) on injured reserve Friday, John Boyle of the Seahawks' official site reports.
Penny's move to IR was merely a formality after he underwent season-ending surgery Tuesday to repair his left ankle and fractured fibula. The transaction opens up a spot on the 53-man roster, but it's unclear if Seattle plans to use it on another running back. Seattle already claimed Tony Jones off waivers from New Orleans earlier this week to add depth behind rookie Kenneth Walker, who is expected to step into a lead role out of the backfield beginning with Sunday's game against the Cardinals.
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Justice Hill RB | BAL
Ravens' Justice Hill: Unlikely to play Sunday
Hill (hamstring) is listed as doubtful for Sunday's game against the Giants.
Though Hill was able to practice in a limited fashion this week, he's trending toward being inactive Sunday. If he's out, Kenyan Drake would be a candidate to log added change-of-pace work behind J.K. Dobbins, with Mike Davis also in reserve. Moreover, it's also possible that Gus Edwards (knee) could be activated from the PUP list in advance of Sunday's contest.
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Alexander Mattison RB | MIA
Vikings' Alexander Mattison: Iffy for Week 6
Vikings head coach Kevin O'Connell said Mattison (shoulder) will be listed as questionable for Sunday's game against the Dolphins, Alec Lewis of The Athletic reports.
According to Ben Goessling of the Minneapolis Star Tribune, O'Connell thinks Mattison will be able to suit up Sunday, but official confirmation on the running back's status won't come one way or the other until the Vikings release their inactive list 90 minutes prior to the 1 p.m. ET kickoff. If available, Mattison should handle his usual complementary role behind Dalvin Cook, though Mattison could see at least a slight drop from the season-high 46 percent snap share and 12 touches he took on during last week's win over the Bears.
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Darrel Williams RB | NO
Cardinals' Darrel Williams: Won't play Week 6
Head coach Kliff Kingsbury said Williams (knee) won't play in Sunday's game against the Seahawks, Darren Urban of the Cardinals' official site reports.
As expected, the sprained knee Williams suffered in the Week 5 loss to the Eagles will keep him out for at least one game, with Kingsbury also expressing uncertainty about the running back's chances of making it back for a Thursday night contest Week 7 against the Saints. Top back James Conner (ribs) is also set to sit out in Seattle, likely leaving Eno Benjamin in position to start and handle a lead role out of the Arizona backfield. Rookie sixth-round pick Keaontay Ingram and practice-squad call-up Corey Clement are expected to handle depth roles behind Benjamin.