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Kyle Monangai RB | CHI
Bears' Kyle Monangai: Big day in Week 1 rout
Monangai carried the ball 10 times for 100 yards and a touchdown and caught both his targets for 24 yards in Sunday's 59-37 win over the Panthers.
In the highest-scoring Week 1 game in NFL history, Monangai carved out his share of the production, although he took a back seat to D'Andre Swift's three TDs and 134 scrimmage yards. Coach Ben Johnson's offensive scheme led to big numbers for his running backs in Detroit, and it looks like more of the same will be in store for Chicago's backfield in his second year at the helm. Monangai will look to make a splash again at home in Week 2 against the Vikings.
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Bijan Robinson RB | ATL
Falcons' Bijan Robinson: Bright spot in Week 1 loss
Robinson rushed 21 times for 83 yards and brought in eight of 10 targets for 90 yards and a touchdown in the Falcons' 20-13 loss to the Steelers on Sunday. He also committed two fumbles, losing neither and recovering one.
The Falcons' offense was hamstrung by the fact it was down to its third-string quarterback in Cooper Rush, who was also battling back spasms leading into the game. Robinson still toughed out yards on the ground throughout the afternoon, and he was Rush's safety valve early and often. Robinson comfortably led his squad in all of receptions, receiving yards and targets, and his 23-yard catch-and-run TD grab late in the first quarter served as Atlanta's only touchdown of the afternoon. The fourth-year pro will remain in a workhorse role for as long as he's healthy, and the star running back could see an upgrade at quarterback for a Week 2 divisional home matchup against the Panthers next Sunday if either Tua Tagovailoa (oblique) or Michael Penix (knee) is able to prove healthy enough to garner active status.
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D'Andre Swift RB | CHI
Bears' D'Andre Swift: Three-TD day in massive Week 1 win
Swift carried the ball 18 times for 124 yards and three touchdowns while catching his only target for 10 yards in Sunday's 59-37 win over the Panthers.
In the highest-scoring Week 1 game in NFL history, Swift scored one-yard TDs in the first and third quarters before icing the contest with a 28-yard scamper on the Bears' final possession in the fourth. Swift tied his career high with 10 total touchdowns (nine rushing, one receiving) in 2025, but he's well on his way to shattering that mark this season. The 27-year-old RB will look for another productive day at home in Week 2 against the Vikings.
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Dylan Sampson RB | CLE
Browns' Dylan Sampson: On crutches after hurting knee
Sampson was on crutches and wearing a brace on the left knee he injured during Sunday's loss to Jacksonville, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Sampson was hurt in the first quarter. He was initially deemed questionable but was eventually downgraded to out after being evaluated in the medical tent and the locker room. Quinshon Judkins (12 carries) and Raheim Sanders (one carry) were the only Browns running backs to log any totes during the Week 1 defeat. Sampson is slated to undergo further testing Monday, per Daniel Oyefusi of ESPN.com.
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Derrick Henry RB | BAL
Ravens' Derrick Henry: Dominant in Week 1 win
Henry rushed 24 times for 144 yards and three touchdowns and brought in his only target for 19 yards in the Ravens' 41-23 win over the Colts on Sunday.
Much like he'd done at the expense of the Bills in Week 1 of last season, Henry turned in one of his signature performances right out of the gate, and he struck for his first two touchdowns in the first half from four and 32 yards away. The superstar running back added a three-yard scoring run early in the fourth quarter, and he consistently ripped off chunk gains throughout the afternoon at the expense of an overwhelmed Colts front. Henry's workload won't change under new head coach Jesse Minter if Sunday is any indication, and the perennial Pro Bowl back carries a stellar outlook for a Week 2 home matchup against a Saints defense that the Lions' Jahmyr Gibbs gashed for 156 rushing yards and two touchdowns Sunday.
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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Strong numbers in lopsided loss
Taylor rushed 19 times for 98 yards and two touchdowns and brought in three of four targets for 23 yards in the Colts' 41-23 loss to the Ravens on Sunday. He also lost a fumble.
Taylor and the Colts' offense as a whole got the new season off to a highly encouraging start, capping off a crisp opening drive with the star running back's one-yard touchdown run. Taylor would go on to add a three-yard scoring rush late in the first half after the Ravens had gone on to rattle off 28 straight points, with Taylor's fumble after a 14-yard reception leading to one of Baltimore's touchdowns. Outside of the turnover, Taylor's overall numbers in a game during which his rushing opportunities were capped late were still useful for fantasy managers, and he'll be slated for another prominent role in a Week 2 road showdown against the Chiefs next Sunday night.
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James Cook III RB | BUF
Bills' James Cook: Held in check by Houston
Cook rushed 13 times for 57 yards and caught three of four targets for 12 yards in Sunday's 36-31 win over the Texans.
Cook didn't find much room against Houston's stout front and took a back seat to Josh Allen, who had two rushing touchdowns and two touchdown passes. Allen's presence didn't stop Cook from rushing for a league-high 1,621 rushing yards during the 2025 regular season, so there should be better days ahead for Buffalo's shifty running back. Cook will have a short turnaround before Buffalo's home opener against the Lions on Thursday.
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Chase Brown RB | CIN
Bengals' Chase Brown: Gets into end zone in win
Brown rushed 16 times for 56 yards and a touchdown and brought in five of six targets for 22 yards in the Bengals' 33-27 win over the Buccaneers on Sunday.
As his final line indicates, Brown unsurprisingly found running room at a premium against the Buccaneers' typically stingy front. Nevertheless, head coach Zac Taylor stuck with the ground attack throughout the afternoon, and Brown, as expected, comfortably outpaced backfield mate Samaje Perine by 11 carries. The versatile back recorded his one touchdown from five yards out with just under six minutes remaining in the second quarter, and he finished tied for the team lead in receptions while also serving as co-runner-up in targets. Brown's busy afternoon should be the norm for him this season, and he'll look to grind out some tough yards again in a Week 2 road showdown against the Texans next Sunday.
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David Montgomery RB | HOU
Texans' David Montgomery: Three total TDs in Texans debut
Montgomery rushed 20 times for 60 yards and two touchdowns while catching all three of his targets for 19 yards and a touchdown in Sunday's 36-31 loss to the Bills.
Montgomery scored Houston's first two touchdowns of the season with a one-yard run in the first quarter followed by an 18-yard run in the second. The offseason trade acquisition from Detroit added a third touchdown on a seven-yard catch as the Texans pulled ahead 28-27 early in the fourth quarter, but Houston's vaunted defense failed to hold that lead. Montgomery's 23 touches in his Texans debut were more than he had in any of his 17 regular-season appearances in 2025 for Detroit, where he had to share the backfield with Jahmyr Gibbs. Woody Marks had 10 touches for 40 yards in a change-of-pace role behind Montgomery, but the latter is clearly Houston's top running back heading into a Week 2 home game against the Bengals.
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Breece Hall RB | NYJ
Jets' Breece Hall: Tops century mark in Week 1 win
Hall rushed 22 times for 102 yards and a touchdown while catching both of his targets for 16 yards in Sunday's 23-10 win over the Titans.
The Jets overpowered the Titans at the line of scrimmage, controlling the clock with the running game while keeping Tennessee to three points through 57 minutes. Hall didn't enjoy many favorable game scripts as the Jets went 3-14 last season, but he capitalized on the heavy workload in the season-opening win while racking up 24 touches to Braelon Allen's 10. Rookie TE Kenyon Sadiq scored a three-yard rushing touchdown in the first quarter as new OC Frank Reich reached deep into his playbook early, but Hall also found the end zone with a four-yard touchdown run in the third quarter. Hall and the Jets will look to build on this strong start in their Week 2 home opener against the Packers.