Coach Kyle Shanahan said Purdy (toe) won't practice Wednesday, Cam Inman of The San Jose Mercury News reports.

Purdy aggravated a turf toe injury Week 4 against the Jaguars and missed last Thursday's win at the Rams. After the latter contest, Shanahan relayed to Ian Rapoport of NFL Network that Purdy was "week-to-week," and on Wednesday, Shanahan added that the quarterback is "progressing," and the 49ers haven't thought about placing him on injured reserve, according to David Lombardi of SFStandard.com. Purdy seems to be trending toward another absence Sunday in Tampa Bay, something that the team may confirm as soon as it posts its final Week 6 practice report Friday.

Jackson (hamstring) remained sidelined at practice Wednesday, Jeff Zrebiec of The Athletic reports.

Jackson didn't practice last week before being ruled out for this past Sunday's 44-10 loss to the Texans. At this stage, the star QB's Week 6 status is cloudy, with Ian Rapoport of NFL Network suggesting earlier Wednesday that Jackson seems to be facing an uphill battle to be available this weekend against the Rams. If he ends up out again, then Cooper Rush would presumably be in line for another start at QB for the Ravens, who will head into their bye week after facing Los Angeles.

Browning is set to move into a backup role with Joe Flacco having been named the starting QB for Sunday's game against the Packers, Geoff Hobson of the Bengals' official site reports.

With Browning having gone 0-3 as a starter since taking over for franchise QB Joe Burrow (toe) -- who is on IR -- in Week 3, the Bengals traded for Flacco on Tuesday. Coach Zac Taylor then quickly made the change at signal-caller, while noting Wednesday, per Paul Dehner Jr. of The Athletic, that Flacco's style "fits our style" and that the 40-year-old will take all the first-team QB reps ahead of Week 6 action.

Coach Zac Taylor revealed Wednesday that Flacco will start Sunday's game against the Packers, Geoff Hobson of the Bengals' official site reports.

The Bengals acquired Flacco from the Browns on Tuesday, and Taylor quickly named the veteran QB the starter for the 2-3 team, which has dropped three straight games. With Flacco moving into into the No. 1 signal-caller role, Jake Browning is in line to work in a backup capacity this weekend. Flacco thus represents an option for those in two-QB formats or who are looking for a bye week plug-in ahead of Week 6 action.

Cardinals coach Jonathan Gannon said Wednesday that Murray (foot) will not practice, Darren Urban of the Cardinals' official site reports.

Gannon said "we'll see" regarding Murray's status for Week 6, echoing his comments from Monday. The starting quarterback missed just three snaps during the third quarter of Arizona's 22-21 loss to the Titans in Week 5 due to the injury, but he now appears up-in-the-air for Sunday's road matchup against the Colts. Murray will have two more opportunities to practice before the Cardinals have to assign him an injury designation for Sunday, but if he can't go, Jacoby Brissett will be in line to draw a start at Indianapolis.

The Browns could promote Zappe to the active roster ahead of Sunday's game in Pittsburgh, Zac Jackson of The Athletic reports.

Cleveland released its updated unofficial depth chart for Week 6 on Tuesday, with Dillon Gabriel as the starting quarterback and Shedeur Sanders being listed as the backup after the Browns shipped Joe Flacco to the Bengals on Tuesday. However, Sanders may not necessarily serve as the No. 2 quarterback come Sunday. Instead, the Browns may view Zappe -- who has made nine career NFL starts -- as being more game-ready than the rookie Sanders, who could remain inactive on game days as the team's emergency No. 3 quarterback.

Head coach Kevin O'Connell said Monday that McCarthy (ankle) will get "extensive work" on the field while the Vikings are on bye Week 6, Kevin Seifert of ESPN.com reports.

Assuming McCarthy's right high-ankle sprain responds well to the on-field activity over the next few days, the second-year quarterback is expected to be reintegrated into practices in Week 7 following a three-week absence. Veteran Carson Wentz started in each of the last three games while McCarthy has been sidelined and led Minnesota to a 2-1 record, but Wentz's status is now in question after he was briefly forced out of this past Sunday's win over the Browns with a left shoulder injury. O'Connell didn't provide many details on Wentz's injury Monday, beyond noting that the 32-year-old is "pretty sore" and set for further evaluation. The practice activity of both quarterbacks will be worth monitoring in Week 7, and O'Connell will likely take into account the health of both signal-callers before naming a starter ahead of the Vikings' next game Oct. 19 versus the Eagles.

The Saints cut Mellott from the practice squad Tuesday.

Mellott was selected in the sixth round of the 2025 NFL Draft by the Raiders but failed to make the team out of training camp as a developmental project. The former college quarterback has been trying to make it as a receiver in the pros.

Dart (hamstring) was listed as a full participant for Tuesday's walk-through practice, Dan Salomone of the Giants' official site reports.

Though Tuesday's session wasn't conducted at full speed, Dart didn't face any limitations and looks to be ready to play Thursday against the Eagles. Head coach Brian Daboll acknowledged as much prior to the walkthrough, telling Evan Barnes of Newsday that Dart's sore left hamstring wasn't viewed as much of a concern, even on a short week. After leading the Giants to an impressive win over the Chargers in his first NFL start in Week 4, Dart took a step back in a disappointing loss to the previously winless Saints in Week 5, committing three turnovers on the afternoon. However, Dart still managed to produce a fantasy friendly line in the loss, throwing for 202 yards and two scores while adding 55 yards on seven carries.

The Bengals released Rypien on Tuesday.

The Bengals shook up their quarterback depth chart Tuesday, cutting Rypien from the active roster and Mike White from the practice squad while adding Joe Flacco in a trade with the Browns.