San Francisco waived Isabella (ankle) with a failure to disclose physical condition designation Tuesday, Aaron Wilson of KPRC 2 Houston reports.
It wasn't a full week after Isabella signed with the 49ers before he suffered an ankle injury, per Matt Barrows of The Athletic, and he's now getting waived. In a corresponding transaction, San Francisco signed wide receiver Equanimeous St. Brown on Tuesday.
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49ers' Andy Isabella: Exits practice Monday
Rotowire
Isabella left practice Monday with an undisclosed injury, Nick Wagoner of ESPN.com reports.
The wide receiver signed with the 49ers on Thursday with the possibility of competing for a depth spot in a crowded receiver room. At the same time, Isabella was not able to elevate from Pittsburgh's practice squad in 2024, got cut by the Bills before last season and last caught an NFL pass in 2022 with the Cardinals. Any missed time will naturally hurt his chances of latching on to a roster spot.
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49ers' Andy Isabella: Signs with San Francisco
Rotowire
The 49ers signed Isabella to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
Isabella hasn't caught a regular-season pass since the 2022 season with the Cardinals, the team that selected him in the second round of the 2019 Draft. Isabella spent time in the UFL with the St. Louis Battlehawks earlier this year. He should be viewed as a longshot to make the Niners' 53-man roster.
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Andy Isabella: Cut from Steelers' practice squad
Rotowire
Isabella was let go from the Steelers' practice squad Tuesday, Teresa Varley of the team's official site reports.
Isabella spent the first two months of the regular season without a team after failing to make the Bills' 53-man roster at the end of training camp. He managed to catch on with the Steelers' practice squad Oct. 25, but he was not elevated for a game. Assuming he clears waivers, Isabella will look to join a team in need of depth at wide receiver.
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Andy Isabella: Joins Pittsburgh's practice squad
Rotowire
The Steelers signed Isabella to the practice squad Friday.
Isabella, who spent time with the Bills during the offseason, will now get a chance to operate in an emergency depth role for Pittsburgh. The 2019 second-round pick has appeared in four combined regular-season games with Buffalo over the last two years.
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Andy Isabella: Cut by Buffalo
Rotowire
The Bills released Isabella on Tuesday, Alaina Getzenberg of ESPN.com reports.
Selected with the No. 62 overall pick in the 2019 NFL Draft by the Cardinals, Isabella was cut by Arizona in October of 2022 and has spent the last couple years bouncing around the practice squads and active rosters of the Ravens and Bills. Now 27, Isabella is running out of time in the NFL and hasn't caught a regular-season pass since he left the Cardinals.
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Bills' Andy Isabella: Recovers from injury
Rotowire
Isabella (leg) returned to practice Wednesday, Joe Buscaglia of The Athletic reports.
Isabella was able to make a quick recovery after being carted off the field Monday. The 27-year-old is likely facing an uphill battle to make the Bills' final 53-man roster, but his speedy return to the field should keep him in contention for now.
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Bills' Andy Isabella: Signs with Bills
Rotowire
Buffalo signed Isabella to a reserve/future contract Monday.
Isabella was active for the Bills' divisional-round loss versus the Chiefs, and now he'll get a chance to compete for a spot on Buffalo's 53-man roster for 2024. Over four games this season (including playoffs), he drew one target, which he failed to haul in, and two kick returns for 44 yards.
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Bills' Andy Isabella: Elevated for Sunday
Rotowire
The Bills elevated Isabella to the active roster Saturday.
Isabella was promoted from the practice squad for the Bills' AFC wild-card victory over the Steelers. He returned one kickoff for 19 yards and did not haul in his lone target. With Gabe Davis (knee) ruled out for Sunday's AFC divisional round contest against the Chiefs, Isabella will likely see the playing field, albeit in a limited role on special teams.
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Andy Isabella: Reverts to practice squad
Rotowire
Isabella reverted to Buffalo's practice squad Tuesday, per the NFL's transaction log.
Isabella had a 19-yard kickoff return and didn't catch his only target in Monday's 31-17 wild-card round win over the Steelers. He played seven snaps on offense and 14 on special teams. The wide receiver will be a candidate to be elevated prior to Sunday's divisional round home game against the Chiefs.
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Bills' Andy Isabella: Bumped up from practice squad
Rotowire
Isabella was elevated to the active roster from the practice squad Sunday.
Isabella will receive his first opportunity with the Bills since Week 12 as the team prepares to take the field against the Steelers on Monday without Gabe Davis (knee). The former has been on Buffalo's practice squad since the season started, receiving two elevations, which resulted in just one snap on offense.
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Bills' Andy Isabella: Elevated for Sunday
Rotowire
The Bills elevated Isabella from their practice squad Saturday.
This is the second time Isabella has been elevated to the active roster this season since joining the Bills' practice squad Aug. 30. In his first appearance in Week 8 against the Buccaneers, Isabella played nine snaps on special teams without recording a stat.
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Andy Isabella: Practice squad bound
Rotowire
Isabella was reverted back to the Bills' practice squad Friday, per the NFL's transaction log.
The 2019 second-round pick was promoted to Buffalo's active roster ahead of the team's Thursday night affair, but he's since been reverted back to the practice squad. Isabella has recorded 33 receptions for 447 yards and three touchdowns throughout his five-year NFL career.
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Bills' Andy Isabella: Gets elevated for Thursday
Rotowire
Buffalo elevated Isabella from its practice squad to the active roster for Thursday's game versus Tampa Bay.
Isabella is in position to make his 2023 debut in Week 8 on Thursday Night Football. Barring an injury to Stefon Diggs or Gabe Davis though, his theoretical path to significant playing time is difficult to see.
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Andy Isabella: Sticks with Bills' practice squad
Rotowire
Isabella signed with the Bills' practice squad Wednesday, Sal Maiorana of the Rochester Democrat and Chronicle reports.
Isabella was cut by Buffalo on Tuesday, but he'll stick around on the organization's practice squad. The 2019 second-round pick of the Cardinals has appeared in 41 NFL games between Arizona and Baltimore.
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Andy Isabella: Misses final roster
Rotowire
Isabella has been cut by the Bills, Sal Maiorana of the Rochester Democrat and Chronicle reports.
The former Arizona Cardinal had some bright spots in the preseason, but in the end the Bills will go with other "maybes" such as Trent Sherfield and Justin Shorter to fill out their wide receiver room. Isabella offers enough speed and kick return ability that he's probably not out of NFL chances.
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Bills' Andy Isabella: Key role in preseason win
Rotowire
Isabella caught all three targets for 42 yards in Buffalo's preseason win over the Colts on Saturday. He also returned three kickoffs for 48 yards and one punt for five yards.
Isabella is one of the newest members of the Bills, signing July 28, and it's a crowded receiver room that he's walked into. However, with running back Nyheim Hines being lost for the season with a knee injury, the Bills are looking for speed in terms of depth and being able to return kicks. Isabella will have to leapfrog a few people to land a spot on the team, but he's off to a good start.
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Bills' Andy Isabella: Links up with Buffalo
Rotowire
Isabella is signing with the Bills, Aaron Wilson of KPRC 2 Houston reports.
The 2019 second-round pick is an undersized receiver with sub-4.4 speed, now on his third NFL team after spending three-plus seasons with the Cardinals and most of last year with the Ravens. Isabella will turn 27 midseason and will need to compete with a slew of young players for a spot at the bottom of the depth chart in Buffalo.
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Andy Isabella: Released by Baltimore
Rotowire
Isabella was released by the Ravens on Tuesday, Field Yates of ESPN reports.
Isabella signed with the Ravens' practice squad in October and was elevated to the active roster twice before the conclusion of the 2022 campaign, but he will now look for a new squad ahead of the 2023 campaign. The 2019 second-round pick by the Cardinals has struggled to be productive over his four-year NFL career, so he'll look to turn that around wherever he ends up next.
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Andy Isabella: Reverts to practice squad
Rotowire
Isabella reverted to Baltimore's practice squad Monday, per the NFL's transaction log.
Isabella was elevated for a third (and final) time during the wild-card loss to Cincinnati but failed to log any counting stats across three offensive snaps. He made five appearances during the 2022 campaign (three with Arizona and two with Baltimore) and caught two of five targets for 21 yards, which all came as a Cardinal.
