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Lamar Jackson QB | BAL
Ravens' Lamar Jackson: Viewed as 'unlikely' for Week 5
Jackson appears "unlikely" to play Sunday against the Falcons due to a "rarer type of ankle sprain" that could put him at risk of missing multiple games, Ian Rapoport of NFL Network reports.
The ankle injury sidelined Jackson for the entire second half of last Sunday's 24-18 win over the Titans, resulting in backup Tyler Huntley directing the offense for the final two quarters. Huntley now appears to be trending toward the Week 5 start while Jackson recovers from the ankle issue, which Rapoport suggests is an "unconventional" injury that's not necessarily a low- or high-ankle sprain. The Ravens are expected to take a week-by-week approach with their star quarterback, who isn't believed to be at risk of a long-term absence but could end up sitting out more than one game, depending on how he responds to rehab.
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Dante Miller RB | NYG
Dante Miller: Clear of injury
Miller (groin) was cleared of any injury designation Tuesday, Jordan Raanan of ESPN.com reports.
Miller was waived by the Giants with an injury settlement in mid-August. Now, with no injury designation, the 27-year-old can re-sign with the Giants this season. The third-year pro played two games with New York in 2024, recording seven special teams snaps and one on offense.
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DeMarvion Overshown LB | DAL
Cowboys' DeMarvion Overshown: Longshot to play Week 5
Cowboys head coach Brian Schottenheimer said Tuesday that Overshown (hamstring) is a "long shot" to play Thursday night against Tampa Bay, Joe Hoyt of The Dallas Morning News reports.
Overshown will likely miss a fourth consecutive game with the Cowboys playing on a short-week Thursday night. The 26-year-old has not practiced since leaving Week 1 with a hamstring injury. Shemar James will continue to see more playing time in his absence.
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Lane Johnson OT | PHI
Eagles' Lane Johnson: Opts for retirement
Johnson announced Tuesday via social media that he has retired from professional football.
Johnson's decision to step away from the game comes after he was a surprise inactive ahead of this past Sunday's loss to the Rams while he tended to a personal matter. In his statement released Tuesday, the 36-year-old Johnson cited a desire to focus on his mental health and spend more time with his family as his reason for bringing an end to his career. The No. 4 overall pick in the 2013 NFL Draft, Johnson was widely regarded as the top right tackle of his generation. He spent all 14 of his NFL seasons with the Eagles, taking home two Super Bowl titles while earning All-Pro honors five times.
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Deuce Vaughn RB | HOU
Deuce Vaughn: Signs to practice squad
The Texans signed Vaughn to the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
Vaughn had a brief stint with the Texans in August before being waived ahead of Week 1. The 24-year-old has not played in a regular-season game since the 2024 season, where he recorded 17 rush attempts for 70 yards and caught three of five targets for 18 yards.
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Christopher Brooks RB | GB
Packers' Chris Brooks: Undergoes tests on ankle
Brooks underwent further tests on his ankle Monday, Weston Hodkiewicz of the Packers' official site reports.
Brooks underwent further tests on his ankle after leaving Sunday's Week 4 game with an ankle injury. The 26-year-old has seen more reps through four weeks with starter Josh Jacobs (personal) remaining out.
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Dillon Gabriel QB | CLE
Browns' Dillon Gabriel: Slated to begin practicing
The Browns opened Gabriel's (back) 21-day practice window Tuesday.
After Gabriel sustained a back injury in their final preseason game, the Browns used one of its eight designations for return on Gabriel upon placing him on injured reserve Aug. 30. Now that he's missed the requisite four games, Gabriel is eligible to be activated from IR at any point, but the Browns may wait closer to the end of the 21-day window to reinstate him. Once he's added back to the 53-man roster, Gabriel will likely slot third on the depth chart at quarterback behind Deshaun Watson and Shadeur Sanders.
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Jamari Thrash WR | LV
Jamari Thrash: Works out for Denver
Thrash worked out with the Broncos on Tuesday, Mike Garafolo of NFL Network reports.
Thrash was waived from the Browns' injured reserve in early September with an undisclosed injury. He has yet to play this season, but the workout with Denver hints at a possible return. The 25-year-old secured 10 of 15 targets for 107 yards and no touchdowns in nine games during the 2025 season.
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Arden Key DE | IND
Colts' Arden Key: Set to miss time
Colts head coach Shane Steichen said Tuesday that Key is expected to miss three to four weeks with a hamstring injury, per Jeremy Fowler of ESPN.com.
Key's availability was already in doubt for Week 5 after sustaining a hamstring injury in Sunday's win over Washington, he's now set to miss the next three to four weeks for the Colts. JT Tuimoloau and Caden Curry will increase reps on the defensive line while Key is out.
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Durham Smythe TE | BAL
Ravens' Durham Smythe: Out for season with torn Achilles
Smythe was diagnosed with a torn Achilles tendon following an MRI on Monday and will require season-ending surgery, Ian Rapoport of NFL Network reports.
The Ravens had been concerned that Smythe ruptured his Achilles during Sunday's win over the Titans, and the MRI ended up confirming the team's fears. The 31-year-old tight end suited up for each of the Ravens' first four games, serving mainly as a blocker while contributing a four-yard reception on two targets. He'll be ticketed for free agency in the spring after signing a one-year, $3 million deal with Baltimore in the offseason.