NFL Player News

Head coach Kyle Shanahan said after Sunday's 35-10 loss to the Bills that McCaffrey (knee) suffered a PCL injury in the contest that may be season-ending, Ian Rapoport of NFL Network reports.

Making only his fourth appearance after missing the 49ers' first eight games due to a strained calf and bilateral Achilles tendinitis, McCaffrey injured his right knee while he attempted to plant his feet and move upfield on a pitch, only to slide down and take a five-yard loss. After initially heading to the locker room and being listed as questionable to return, McCaffrey was ruled out for the rest of the night. The star running back will likely undergo further testing Monday to confirm that he's dealing with a PCL injury, and in the likely event that McCaffrey misses time, Jordan Mason and Isaac Guerendo will be relied upon to lead San Francisco's backfield. If McCaffrey doesn't play again in 2024, he'll finish the campaign with 50 carries for 202 yards, 15 catches on 19 targets for 146 yards and zero total touchdowns.

Davis rushed 11 times for 63 yards and a touchdown while catching his only target for four yards in Sunday's 35-10 win over the 49ers.

Davis was involved early, scoring a five-yard rushing touchdown in the first quarter, but most of his yardage came later in the game after the result was no longer in doubt. James Cook (14 carries for 107 yards and a touchdown) paced Buffalo's backfield as usual, but Davis benefited from a run-heavy game plan in snowy conditions. Davis will continue to work as the team's No. 2 running back behind Cook in Week 14 against the Rams.

Cook rushed 14 times for 107 yards and a touchdown while catching his only target for 13 yards in Sunday's 35-10 win over the 49ers.

Cook outraced San Francisco's defense down the sideline for a 65-yard rushing touchdown in the second quarter after watching Ray Davis cap the previous drive with a five-yard touchdown run. Buffalo's run-heavy game script helped Cook exceed 100 rushing yards for only the second time this season, as he came four yards short of his Week 8 season high against the Seahawks. Cook also raised his rushing touchdown total to 11, which is a marked improvement from his two rushing touchdowns apiece in 2022 and 2023. He'll look to continue his success against NFC West competition in Week 14 against the Rams.

Brooks rushed the ball six times for 18 yards in Sunday's 26-23 overtime win against the Buccaneers. He added three receptions on three targets for 23 yards.

Brooks wasn't all that impressive with his rushing opportunity, but he saw his carry total jump from two to six in his second pro game. He was also much more effective as a receiver, highlighted by a shifty 18-yard catch and run late in the first quarter. While Brooks is unlikely to overtake Chuba Hubbard to lead the Carolina backfield, it appears clear that he will continue to carve out a role moving forward.

Hubbard rushed the ball 12 times for 43 yards in Sunday's 26-23 overtime loss to the Buccaneers. He was not targeted.

Hubbard continued to lead the Carolina backfield, though he out-touched Jonathon Brooks by a margin of only 12-9. He was also held in check for most of the game, as his longest gain went for only nine yards and he had a fumble in overtime that cost the Panthers a chance at victory. Perhaps most concerning in regards to role was Hubbard's lack of involvement as a receiver, as this marked only the third time this season that he wasn't targeted. He has at least four receptions in six contests for the campaign, which has served as a significant portion of his fantasy value.

McCaffrey (knee) won't return to Sunday's game against the Bills.

McCaffrey was ruled out at halftime after limping to the locker room in the first half. Jordan Mason and Isaac Guerendo will lead San Francisco's rushing attack in the second half. McCaffrey will finish the night with seven carries for 53 yards and two catches for 14 yards on three targets. His next chance to play will be Week 14 against the Bears.

Irving rushed the ball 25 times for 152 yards and one touchdown in Sunday's 26-23 overtime win over the Panthers. He added three catches on three targets for 33 yards.

Irving had secured an increased role in the Tampa Bay offense in recent weeks, but he took over the backfield in Sunday's win. He accounted for 25 of 36 carries by the team's running backs, four of which went for double-digit gains --highlighted by a 43-yard pickup to help set up a field goal late in the fourth quarter. Irving also found the end zone for the third straight game and could be in for some additional big performances down the stretch.

McCaffrey (knee) is questionable to return to Sunday's game against the Bills.

McCaffrey felt something in his leg and slid down immediately after receiving a toss in the second quarter, then got up limping and promptly went to the medical tent. The star running back went to the locker room soon thereafter, per Cam Inman of the Bay Area News Group. McCaffrey had been off to a strong start in snowy Buffalo prior to the injury, rushing seven times for 53 yards and catching two of three targets for 14 yards. Jordan Mason and Isaac Guerendo will comprise San Francisco's backfield in McCaffrey's absence.

Henry rushed 19 times for 82 yards and brought in all three of his targets for 29 receiving yards in Sunday's 24-19 loss to the Eagles.

Henry didn't post a monstrous stat line like we have become accustomed to over the course of his storied career, but he still produced 111 yards from scrimmage without turning the ball over. The simple fact that this performance checked out as one of Henry's lowest fantasy scores of the season paints a picture of how dominant King Henry has been since aligning with Lamar Jackson in Baltimore this season. With the added rest from Baltimore's upcoming bye, Henry should be locked in for a strong finish to the campaign when the Ravens resume play against the Giants on Dec. 15.

Brown rushed the ball 12 times for 70 yards and a touchdown in Sunday's 44-38 loss to the Steelers. He added three receptions on three targets for 30 yards.

Brown looked to be in for a huge game as he accounted for 54 rushing yards and a score on the Bengals' second offensive possession. However, Cincinnati found itself chasing the lead for much of the second half, which led to Brown getting only four carries in the final two quarters. Nevertheless, he remains the clear lead back and has now found the end zone or topped 100 yards from scrimmage in five consecutive matchups.