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Austin Ekeler RB | WAS
Chargers' Austin Ekeler: Could return Saturday
Ekeler (neck/concussion) has a chance to return for Saturday's game against the Ravens, Adam Schefter of ESPN reports.
Ekeler was unable to play in Thursday's 29-28 win over the Chiefs just four days after suffering a neck injury and concussion. He does have a shot to make it back with the Chargers on a long week of rest this time around, but a return won't necessarily equate to a starring role in the offense, as Melvin Gordon (knee) also has a chance to suit up.
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Jeff Wilson RB | MIA
49ers' Jeff Wilson: Over 6.0 YPC in Week 15
Wilson rushed for 46 yards on seven attempts during Sunday's 26-23 win against the Seahawks.
From an undrafted free agent out of North Texas to sixth-string running back at the start of training camp, Wilson's rookie campaign has reached its apex as he prepares for what could be his second start of the season in Week 16 after Matt Breida (ankle) aggravated an injury toward the conclusion of Sunday's overtime win against Seattle. A slight-bodied back at 6-foot, 195 pounds, Wilson has been a pleasant surprise in averaging 4.4 yards per carry and 8.7 yards per touch in four appearances this year, but he's yet to get into the end zone, preventing him from attaining the RB2 upside that often comes as a byproduct of being a team's workhorse back (15-plus carries in Weeks 13 and 14). Wilson is a near-lock to hit 15 touches if Breida is in fact unable to suit up when the 49ers face Chicago's No. 2 rush defense in the penultimate week of the regular season (83.2 yards allowed per game).
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Matt Breida RB | SF
49ers' Matt Breida: Aggravates ankle
Breida aggravated his ankle injury toward the end of Sunday's 26-23 overtime win over the Seahawks, Eric Branch of the San Francisco Chronicle reports.
Breida played until the final few snaps of the game, finishing with 17 carries for 50 yards and five catches for 46 yards (on five targets). The 49ers held him out for a week the last time he aggravated his lingering ankle injury, allowing Jeff Wilson to pile up 23 carries for 90 yards in a 20-14 win over the Broncos in Week 14. While a cautious approach would make sense with the 49ers sitting at 4-10, the team has consistently been aggressive in allowing Breida to play through injuries all season. Wilson would be primed for heavy usage if Breida ends up missing a Week 16 home game against the Bears.
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Nyheim Miller-Hines RB | NO
Colts' Nyheim Hines: Piles up 64 scrimmage yards
Hines carried six times for 19 yards and caught four passes for an additional 45 yards during Sunday's 23-0 win over the Cowboys.
Hines was the only other back to carry the ball behind Marlon Mack, but he averaged just 3.2 yards per carry. He frequently lined up in the slot and on the outside, finishing second on the team in catches and receiving yardage. Hines is more of a change-of-pace option behind Mack, but his receiving chops give him some fantasy value in the right matchup. That said, he's no guarantee to produce next Sunday against the Giants.
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Boston Scott RB | PIT
Eagles' Boston Scott: Inactive Sunday night
Scott (coach's decision) is inactive for Sunday night's game against the Rams, Reuben Frank of NBC Sports Philadelphia reports.
Scott joined the team prior to Week 14 following Corey Clement's knee injury, but the rookie will have to wait at least another week to make his debut. The Eagles will roll with Josh Adams, Darren Sproles and Wendell Smallwood at running back.
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Doug Martin RB | LV
Raiders' Doug Martin: Runs for 39 yards
Martin carried nine times for 39 yards during Sunday's 30-14 loss to the Bengals.
Martin received single-digit carries for the first time since Week 6 and managed a long gain of just nine yards. He failed to bring in his only target in the passing game and now has just two receptions over the last three games combined. Martin rode a three-game touchdown streak into this one, which had given him some fantasy value, but his yardage totals are too light to rely on each week. He'll look to take advantage of a beatable Broncos run defense next Sunday.
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Jamaal Williams RB | NO
Packers' Jamaal Williams: Performs well in relief
Williams rushed for 55 yards and a touchdown on 12 carries and added 42 yards on four catches during Sunday's 24-17 loss to Chicago. Teammate Aaron Jones sprained his knee during the contest, Ian Rapoport of NFL Network reports.
Williams helped tie the game up late in the third quarter, taking the outside handoff and cutting through the Chicago defense on his way to a 10-yard touchdown, his first since Week 8 and just his second of the season. Williams had taken a backseat to fellow sophomore Aaron Jones this season, with Williams recording single-digit touches in eight of his previous nine games entering Sunday. With Jones reportedly battling a sprained knee and little else for Green Bay to play for this season, Williams might carry the load down the stretch. If he does, he'll start off against a middle-of-the-road Jets run defense, surrendering 4.5 yards per carry this season.
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Tallies 44 yards in ugly loss
Edmonds ran for 22 yards on eight carries and added 22 yards on two catches during Sunday's 40-14 loss to Atlanta.
Week 13's two-touchdown game in which Arizona shocked Green Bay appears to have been a blip. Arizona has struggled mightily over the past two weeks with Edmonds not providing much production as David Johnson's clear backup. The rookie back did manage to record double-digit touches for the first time this season, but four of those came in the fourth quarter with the Cardinals down by multiple scores. Maybe, with the season and -- potentially -- this regime on its last legs, Arizona will try to get a better look at what it has in Edmonds. If that ends up being the case, there might be no better opponent than the Rams, who come to town next Sunday ranked as the easiest opponent in the league with 5.1 yards allowed per rush.
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Kenyan Drake RB | GB
Dolphins' Kenyan Drake: Quiet on heels of game-winner
Drake (shoulder) rushed once for six yards and caught all three of his targets for 28 more in Sunday's 41-17 loss to Minnesota.
The hero in last week's win over the Patriots was strangely quiet in this one, as the Dolphins opted to feature rookie running back Kalen Ballage after Frank Gore injured his ankle. Expect Miami to continue with the thunder-and-lightning backfield approach should Gore sit out against the Jaguars in Week 16, with Ballage absorbing most of the early-down work and Drake operating as a receiver and in open space.
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Derrick Henry RB | BAL
Titans' Derrick Henry: Pummels way to big game
Henry carried the ball 33 times for 170 yards and two touchdowns in Sunday's 17-0 win over the Giants. He caught one pass for zero yards.
Henry set a new single-game high in carries and combined that with impressive efficiency to provide another strong fantasy performance. His touches have been on the rise in four consecutive weeks, as the Titans' offensive gameplan has emphasized controlling the ball and clock. That suits Henry's style of running, and it should equate to him remaining the featured back over Dion Lewis and finishing the season strong. Notably, Henry has also done more with his opportunities of late, averaging four or more yards per carry in six of his past seven games.