NFL Player News

Breida (ankle) is listed as questionable for Thursday's game at Arizona, Eric Branch of the San Francisco Chronicle reports.

Brieda managed only two limited practices this week due to the tender ankle, but that might be enough for him to earn an active status once Thursday arrives. If so, he likely will be limited behind lead back Tevin Coleman, especially with fellow reserve Jeff Wilson healthy at the moment. The 49ers will release their list of inactives about 90 minutes before Thursday's 8:20 p.m. ET kickoff.

Edmonds (hamstring) has been ruled out for Thursday's game against the 49ers, Josh Weinfuss of ESPN.com reports.

Edmonds is nursing a hamstring injury that could sideline him for multiple weeks, so his absence Thursday doesn't come as much of a surprise. With the status of No. 1 running back David Johnson (ankle) still up in the air, Arizona's backfield may consist of Kenyan Drake, Zach Zenner and Alfred Morris in Week 9.

Snell (knee) didn't practice Wednesday.

Top back James Conner (shoulder) also didn't practice Wednesday, but Jaylen Samuels -- now recovered from a knee scope -- was able to practice fully and has been declared ready to return to action Sunday against the Colts, per Brooke Pryor of ESPN.com. If Snell is able to play Sunday against the Colts, he would work in a complementary role behind Conner (if available) and/or Samuels.

Sanders (shoulder) said that he expects to suit up for Sunday's game against the Bears, Les Bowen of the Philadelphia Daily News reports.

Sanders was unable to practice Wednesday, but noted that he'll likely be back on the field for Thursday's session in some capacity. During Sunday's win over the Bills, the rookie running back reportedly aggravated a shoulder injury that dates back to his time at Penn State. While it's certainly good news that the 22-year-old has avoided a significant injury, the Eagles could take a cautious approach with him ahead of a Week 10 bye. If Sanders ends up sitting against the Bears, Darren Sproles (quadriceps) -- if cleared to play -- and Boston Scott would be candidates for change-of-pace roles behind Jordan Howard.

Conner (shoulder) didn't practice Wednesday.

The same applies to Benny Snell (knee), while Jaylen Samuels (knee) -- who didn't play in Monday's win over the Dolphins -- practiced fully Wednesday. Per Brooke Pryor of ESPN.com, Conner is dealing with an AC joint injury in his right shoulder, which puts his Week 9 status up in the air for now. If Conner is out or limited this weekend against the Colts, Samuels would be in line to see an expanded role on offense.

McCaffrey was limited at Wednesday's practice due to a knee injury, Jourdan Rodrigue of The Athletic reports.

After the session, coach Ron Rivera expressed "no concern" about McCaffrey's health, according to Rodrigue. It still bears watching as the week goes on, but there doesn't seem to be much worry about McCaffrey's availability for Sunday's game against the Titans.

Sanders (shoulder) wasn't spotted at the portion of Wednesday's practice open to the media, Dave Zangaro of NBC Sports Philadelphia reports.

Sanders exited Sunday's win over the Bills due to a shoulder issue. Coach Doug Pederson called Sanders day-to-day on Monday based on the results of his X-rays, indicating that 22-year-old avoided a major injury. The rookie will have two more opportunities to practice in some capacity ahead of the Week 9 tilt against the Bears. With Jordan Howard healthy and capable of carrying the load and Boston Scott also on hand as a change-of-pace option, it wouldn't be a very surprising if Philadelphia's coaching staff opts to take a cautious approach with Sanders' recovery.

Thompson caught his only target for a loss of a yard during Sunday's 31-24 loss to the Packers.

With LeSean McCoy and Damien and Darrel Williams all active, it was a bit of a surprise that Thompson even suited up Sunday, and he didn't see much action on offense. The rookie has just 11 total yards in limited action this season. Even if he plays Sunday, he's a poor option against Minnesota's seventh-ranked rush defense.

Coach Kliff Kingsbury said Drake will have a "manageable workload" Thursday against the 49ers, Josh Weinfuss of ESPN.com reports.

With David Johnson (ankle) day-to-day and Chase Edmonds (hamstring) doubtful to play this week, Kingsbury's comment doesn't exactly inspire confidence that Drake will be the primary back in his first appearance with the Cardinals. Assuming Johnson and Edmonds are sidelined, Drake seems poised to split work with Zach Zenner and Alfred Morris, both of whom have just one more week of experience in the offense. Thursday's matchup versus San Francisco's second-ranked scoring defense doesn't bode well for any of the trio making a significant impact.

Coach Kyle Shanahan said Mostert (knee) will be held out of practice Tuesday, Matt Barrows of The Athletic reports.

Both Mostert and Matt Breida (ankle) will be non-participants, leaving Tevin Coleman and Jeff Wilson as the 49ers' only healthy running backs. There seems to be a chance that Breida won't play Thursday, so if Mostert gets the all-clear to suit up Thursday, he could be the No. 2 or No. 3 RB in what has been an explosive ground attack this season.