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Jamaal Williams RB | NO
Lions' Jamaal Williams: Dealing with chest injury
Williams was limited at Thursday's practice due to a chest injury.
Williams joined No. 1 RB D'Andre Swift (groin) on the injury report, with both having a cap on their reps. Swift's issue has lingered since early in training camp, while Williams' concern is brand new. Both players got a lot of work Week 1, with Swift earning 68 percent of the offensive snaps en route to 19 touches for 104 yards from scrimmage and one TD, while Williams got 35 percent on his way to 17-110-1, respectively. Assuming the pair make it through the current week of prep and play Monday in Green Bay, Williams should have every opportunity to produce against the team that drafted him back in 2017.
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D'Andre Swift RB | CHI
Lions' D'Andre Swift: Logs limited practice
Swift (groin) was a limited practice participant Thursday.
Swift was sidelined for the entire preseason slate due to a groin injury, and there was some question whether he'd be able to handle a full workload Week 1 against the 49ers with veteran back Jamaal Williams on hand. Swift nearly doubled Williams' snap count on offense (63 versus 32) while the pair put up similar stat lines (Swift had 19 touches for 104 total yards and one TD; Williams had 17-110-1, respectively). Now, both backs are limited in practice, with Williams dealing with a chest injury. The Lions don't play until Monday night in Green Bay, so both Swift and Williams have a bit more time than normal to prepare for game day.
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Josh Jacobs RB | GB
Raiders' Josh Jacobs: Absent for another practice
Jacobs (toe/ankle) wasn't present for Thursday's practice, Vincent Bonsignore of the Las Vegas Review-Journal reports.
Jacobs' absence from the Raiders' first Week 2 practice Wednesday wasn't a major surprise after he played 45 snaps two days earlier in the team's overtime win over the Ravens, but a second straight day of no practice participation suddenly raises more concern about his availability for Sunday's game in Pittsburgh. The Raiders will see what Jacobs is able to do at Friday's practice before determining whether he'll carry a designation into the weekend. Kenyan Drake would be the next man up as the Raiders' top option on the ground if Jacobs ends up sitting Sunday.
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La'Mical Perine RB | PIT
Jets' La'Mical Perine: Not on Week 2 injury report
Perine (foot) wasn't listed Wednesday on the Jets' Week 2 injury report.
Perine was inactive Week 1, but he's evidently past the foot issue that he had been managing. However, he's not a lock to suit up Sunday against the Patriots, with Tevin Coleman, Ty Johnson and Michael Carter all part of the Jets' backfield mix and likely ahead of Perine in the pecking order.
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Miles Sanders RB | DAL
Eagles' Miles Sanders: Logs limited practice Wednesday
Sanders was a limited practice participant Wednesday due to an ankle injury and rest.
Sanders was one of three starters on offense to have an injury and "rest" next to his name on Wednesday's practice report. The others -- tight end Zach Ertz (hamstring/rest) and right guard Brandon Brooks (knee/rest) -- were unable to practice at all. As a result, Sanders seems like he'll be OK for Week 2 against the 49ers, but his activity level in the coming days will be something to monitor. In Sunday's season opener in Atlanta, he turned 19 touches into 113 yards from scrimmage on a 66-percent share of the offensive snaps.
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Josh Jacobs RB | GB
Raiders' Josh Jacobs: Misses Wednesday practice
Jacobs didn't practice Wednesday due to toe and ankle injuries, Vic Tafur of The Athletic reports.
Jacobs' exclusion from practice isn't too surprising, with the Raiders having played Monday and the running back having previously suggested that he may have some maintenance days on certain Wednesdays. Still, Tafur notes that Jacobs is banged up at this stage of the week, making his status worth monitoring as Sunday's game against the Steelers approaches. Wednesday's session was a walk-through, so what Jacobs is able to do Thursday should provide better hint about his Week 2 status.
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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Not practicing, as expected
Penny (calf) won't practice Wednesday, John Boyle of the Seahawks' official site reports.
The lack of activity comes as no surprise, with Penny already considered unlikely to play Week 2 against Tennessee. He aggravated a left calf injury in Sunday's win over the Colts, leaving DeeJay Dallas and Travis Homer as the backup running backs, though Alex Collins could also be active this week.
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Jeff Wilson RB | MIA
49ers' Jeff Wilson: On track for midseason return
Wilson (knee) recently resumed running and is still expected to return from the PUP list around midseason, David Lombardi of The Athletic reports.
All eyes are on the San Francisco backfield after a wild Week 1 in which rookie third-round selection Trey Sermon was a healthy scratch and Raheem Mostert suffered a season-ending knee injury. Wilson may eventually help, but his presence on the PUP list means he can't play until Week 7 even if his rehab process speeds up. He had surgery in late May to repair a meniscus tear, with the recovery timeline set at 4-to-6 months.
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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Listed as questionable
The Giants list Barkley (knee) as questionable for Thursday's game at Washington, Zack Rosenblatt of The Newark Star-Ledger reports.
Barkley went down as a limited practice participant Monday through Wednesday, after getting 10 carries and three targets on a 48 percent snap share in Sunday's loss to Denver. Head coach Joe Judge said the running back will increase his workload as the season moves along, but a short week might not be the time for him to return to an every-down role. Between that and the difficult matchup against Washington's defense, Barkley is at least one more week away from reclaiming his familiar status as a locked-in RB1. Still, he's startable in most formats, assuming he's not on the inactive list ahead of Thursday's 8:20 p.m. ET kickoff. The Giants have two starters ruled out -- tight end Evan Engram (calf) and left guard Shane Lemieux (knee) -- while Washington has a healthy defense but no Ryan Fitzpatrick (hip) or Curtis Samuel (groin), who are both on injured reserve.
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Chris Evans RB | CIN
Bengals' Chris Evans: No offensive snaps Week 1
Evans didn't record an offensive snap during Sunday's 27-24 win over the Vikings.
Evans earned a roster spot by beating out Trayveon Williams for the third running back job, but after Week 1, it is clear that he won't be part of the offensive plan, unless Joe Mixon or Samaje Perine are sidelined. The Bengals' run game totaled 34 rushes for 149 yards with Mixon playing 78 percent of the snaps against the Vikings.