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Khalil Herbert RB | SF
Bears' Khalil Herbert: Comes up big in first start
Herbert rushed 19 times for 97 yards and a touchdown while adding two receptions for 15 yards in the Bears' 24-14 loss to the Packers on Sunday.
Herbert had consistent success running the ball against a Packers defense that's struggled against the run this season, and if the Bears didn't trail for much of this contest, he may have had even better production. Even if Damien Williams (illness) returns next week, Herbert should continue to see significant work in a shared backfield until David Montgomery (knee) returns, so he should retain enough value to be a consideration for fantasy lineups for the next few weeks.
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Antonio Gibson RB | NE
Football Team's Antonio Gibson: Hurts calf Sunday
Gibson injured his calf during Sunday's game against the Chiefs, Doug Kyed of Pro Football Focus reports.
Gibson was examined for a shin injury early in the contest but was able to return to action. Now, he's again being looked at by Washington trainers, only this time a calf issue is to blame. If he's unable to get back on the field, Gibson will finish Week 6 with 12 touches for 44 total yards. In Gibson's stead, J.D. McKissic will be the prime beneficiary, though undrafted rookie Jaret Patterson could get some run, too.
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Latavius Murray RB | BUF
Ravens' Latavius Murray: Suffers ankle injury
Murray was forced out of Sunday's game against the Chargers with an ankle injury, Jonas Shaffer of The Baltimore Sun reports.
Prior to his exit from the contest, Murray had logged nine carries for 44 yards and a touchdown to go with two catches for 12 yards. With Murray banged up, Devonta Freeman and Le'Veon Bell are in line to handle the Ravens' backfield duties for the rest of the day.
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Eno Benjamin RB | NO
Cardinals' Eno Benjamin: Inactive once again
Benjamin (coach's decision) is inactive for Sunday's matchup against the Browns, Darren Urban of the Cardinals' official site reports.
Benjamin was active for the first time in his career in Week 5. However, he did not log an offensive snap and will be inactive once again with Chase Edmonds (shoulder) ready to go.
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Damien Harris RB | BUF
Patriots' Damien Harris: Active versus Cowboys
Harris (ribs) is listed as active for Sunday's game against the Cowboys.
Harris was forced out of last weekend's win over the Texans, but he was able to practice in a limited fashion Thursday and Friday and will give it a go Sunday. If the Patriots' top back ends up limited at all or suffers any setbacks against Dallas, added backfield touches would be available for Rhamondre Stevenson and Brandon Bolden.
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Ezekiel Elliott RB | LAC
Cowboys' Ezekiel Elliott: Officially active Sunday
Elliott (ribs) is listed as active Sunday in New England.
The Cowboys capped Elliott's practice reps this week as he dealt with the aftereffects of landing on a camera pylon on the sideline last Sunday against the Giants. The rib issue won't impact his ability to suit up Week 6, but it stands to reason he could yield some work to backup running back Tony Pollard. Still, Elliott has been Dallas' lead runner all season on his way to 18.8 touches for 101.4 yards from scrimmage per game while scoring six TDs in five contests.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Active as expected Sunday
Gordon (hip) is active for Sunday's game against the Raiders.
As expected, Gordon once again will tough out an injury and play after going into the weekend listed as questionable. The veteran also has dealt with rib and lower-leg injuries over the last pair of contests, but he's still logged a combined 65 snaps in those games while splitting time with rookie Javonte Williams, an arrangement that will persist versus Las Vegas.
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Suiting up Sunday
Edmonds (shoulder) is listed as active Sunday at Cleveland, Darren Urban of the Cardinals' official site reports.
Despite having practice limitations for a second week in a row, Edmonds will be available to the Cardinals offense Week 6. He continues to get the better end of offensive snaps over fellow running back James Conner, earning at least 60 percent in all five games while the latter has topped out at 48 percent twice. The result has been 72 touches for 429 yards from scrimmage and no TDs for Edmonds, while Conner has received 67 touches for 235 total yards and five scores.
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Jake Funk RB | JAC
Rams' Jake Funk: Downgraded to out
Funk (hamstring) won't return to Sunday's game against the Giants, according to Jourdan Rodrigue of The Athletic.
As expected, Funk has been downgraded and won't return to the game -- which was a likely scenario given how tricky hamstring injuries can be. His next chance to play will be in Week 7 against the Lions, but his availability will depend on the severity of the injury.