Mitchell (knee) is active for Sunday's game versus the Texans, Keiana Martin of the 49ers' official site reports.
Making his first appearance since Week 13, Mitchell may have some conditioning issues considering he dealt with a concussion and a knee injury during that stretch. Still, he's been the most effective 49ers running back by a long shot this season, averaging 4.6 yards on his 165 carries, reeling in 17 of 18 targets for 126 yards and scoring five touchdowns on the ground in nine appearances. Fellow RB Jeff Wilson ran for 4.4 yards per rush during Mitchell's three-game absence, so Mitchell could yield some reps to the former if he's not yet in top form.