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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Set for limited practice
McCaffrey (knee) will be a limited practice participant Tuesday, Cam Inman of The San Jose Mercury News reports.
Coming out of their Week 15 win over the Seahawks on Thursday, the 49ers haven't indicated that McCaffrey suffered any setbacks with the knee issue that first cropped up in Week 12, so the running back's limitations to begin this week's prep are most likely a matter of maintenance. In the three games since the injury surfaced, McCaffrey has played more than two-thirds of the snaps on offense while averaging 19 carries and seven targets per contest. Another heavy snap and touch count should await McCaffrey in Saturday's game against the Commanders.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Eight touches in win
Perine had seven carries for 24 yards and one reception for no gain in Sunday's 34-23 win over the Buccaneers.
In Joe Mixon's second game back from a two-game absence due to a concussion, Perine saw 38 percent of Cincinnati's offensive snaps compared to the latter's 64 percent. Perine ultimately received half as many touches compared to his backfield mate. This week, New England's stout run defense doesn't provide a particularly appetizing matchup in Week 16.
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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Going to injured reserve
The Colts placed Taylor (ankle) on injured reserve Tuesday, JJ Stankevitz of the team's official site reports.
This comes as no surprise after Taylor suffered a high-ankle sprain during Saturday's 39-36 loss at Minnesota. He's been tending to issues with his right ankle all season, and with three absences to come down the stretch, he'll end up missing six contests overall. In his 11 games of work, though, Taylor racked up 192 carries for 861 yards and four touchdowns and 28 catches (on 40 targets) for 143 yards. Moving forward, Indianapolis will turn to the backfield duo of Zack Moss and Deon Jackson to continue churning out production on the ground.
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AJ Dillon RB | CAR
Packers' AJ Dillon: Avoids concussion protocol
Packers head coach Matt LaFleur said after Monday's 24-12 win over the Rams that Dillon cleared the concussion protocol, Ryan Wood of the Green Bay Press-Gazette reports.
Prior to his departure in the second half of the Week 15 contest, Dillon scored two rushing touchdowns and hauled in all three targets for 35 yards, but he otherwise wasn't very efficient on the ground (11 carries for 36 yards). Meanwhile, Aaron Jones was again productive with 21 touches for 126 yards from scrimmage and a receiving touchdown. With Dillon's health not an issue moving forward, the Packers will have their usual backfield duo available for Sunday's visit to Miami.
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Nick Chubb RB | HOU
Browns' Nick Chubb: Dealing with foot issue
Chubb won't practice Tuesday due to a foot injury, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Chubb hit the 20-carry threshold for the fifth time in 14 appearances this season Sunday against the Ravens, finishing with 99 yards on 21 rushes. His DNP on Tuesday may be maintenance-related as a result, but his status is still somewhat up in the air for Saturday's game against the Saints.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Signed to active roster
The Colts signed Wilkins to the active roster Tuesday, Aaron Wilson of ProFootballNetwork.com reports.
Wilkins was elevated for Weeks 9 and 10, totaling six rushing attempts for 31 yards while securing four of five targets for 15 yards across 21 offensive snaps. However, he'll get an official spot on the active roster with Jonathan Taylor (ankle) on IR for the remainder of the campaign. Wilkins figures to serve as a depth option behind Zack Moss and Deon Jackson.
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Khalil Herbert RB | SF
Bears' Khalil Herbert: Ready to practice
The Bears designated Herbert (hip) for return from injured reserve Tuesday.
Coach Matt Eberflus told Larry Mayer of the team's official site Monday that Herbert was "cleared, ready to go... He looks great." Chicago will see how Herbert looks during Week 16 prep before making a decision on whether to activate him ahead of Saturday's contest against the Bills, which must be done by 4:00 p.m. EST on Friday.
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Kyren Williams RB | LAR
Rams' Kyren Williams: Tallies just two touches
Williams rushed twice for seven yards in Monday's 24-12 loss to the Packers.
Williams took the field for only four snaps in another forgettable performance for the rookie, while Cam Akers tallied 100 total yards of offense between his 15 touches. Any optimism for a Williams breakout during the latter half of the season has been dashed with Akers reclaiming his role as the lead back, and a Week 16 matchup against an imposing Denver defense will make it a tall task to trust Williams in fantasy lineups.
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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Heading to IR
The Colts are expected to place Taylor (ankle) on injured reserve Tuesday, Aaron Wilson of ProFootballNetwork.com reports.
Taylor's placement on IR will officially rule him out for the remainder of the 2022 campaign, after he suffered a right high-ankle sprain during Saturday's narrow loss to the Vikings. In a corresponding move, Indianapolis is promoting Jordan Wilkins to the 53-man roster, joining a backfield that includes Zack Moss and Deon Jackson. Across 11 appearances this season, Taylor carried the ball 192 times for 861 yards and four scores (4.5 YPC), and he secured 28 of 40 targets for another 143 receiving yards.
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Patrick Taylor RB | SF
Packers' Patrick Taylor: Takes season-high four carries
Taylor had four carries for 15 yards in Monday's 24-12 victory over the Rams.
Taylor was signed to the active roster just hours before Monday's contest, and he opened the night as the third running back behind Aaron Jones and AJ Dillon. However, Dillon left the game with a head injury and the Packers did not want to lean solely on Jones, so Taylor picked up four carries on the final drive of the evening. Taylor could operate as the backup in Week 16 if Dillon in unable to go, but in that scenario, Jones would likely handle the bulk of the work in the backfield.