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Jalen Milroe QB | SEA
Seahawks' Jalen Milroe: Will get more reps at practice
Milroe will be more involved in practice ahead of Sunday's game versus Arizona, Curtis Crabtree of Fox 13 Seattle reports.
Sam Darnold (glute) won't suit up in Week 2, meaning Drew Lock will be the team's starting signal-caller. Milroe will occupy the No. 2 spot on the depth chart, so head coach Mike Macdonald wants to be sure he is ready to go in case Lock gets injured.
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Michael Penix Jr. QB | ATL
Falcons' Michael Penix: Could play in Week 2
Penix (knee) was listed as a full participant in Wednesday's practice, Daniel Flick of The Atlanta Journal-Constitution reports.
Penix practiced fully from Wednesday through Friday last week and ultimately was inactive for Week 1, so he is not a lock to suit up for Week 2 just yet. However -- per the same source above -- he shared the first-team work with Cooper Rush on Wednesday, and -- via Marc Raimondi of ESPN.com -- Penix himself indicated he could take the field Sunday. It likely will not be known for a day or two who will start at quarterback for the Falcons in Week 2, but at the least Penix is in the mix.
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Joe Burrow QB | CIN
Bengals' Joe Burrow: Dealing with back tightness, expects to play
Burrow is dealing with back tightness but says he will play Sunday against the Texans, Kelsey Conway of The Cincinnati Enquirer reports.
Per Conway, Burrow threw only one pass during media viewing and was primarily working on handoffs at Wednesday's practice. Burrow later spoke with the media and mentioned dealing with back stiffness, but he added that he'll play Week 2. He didn't confirm whether he'll practice for the remainder of the week, however. Joe Flacco figures to get increased work with the starters in practice, but at this stage it appears Burrow will be able to suit up Sunday.
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Jack Strand QB | ATL
Falcons' Jack Strand: Could be an option in Week 2
Falcons head coach Kevin Stefanski said Wednesday that Strand hasn't been ruled out from being available for Sunday's game against the Panthers, Marc Raimondi of ESPN.com reports.
The Falcons' injury woes at quarterback could lead to Strand being active for a second straight week. Not only are Tua Tagovailoa (oblique) and Michael Penix (knee) dealing with injuries, but Cooper Rush -- who started the Week 1 loss to the Steelers -- is also getting treatment for his back. Tagovailoa didn't practice Wednesday, and while Rush and Penix were both full participants, it's unclear if the Falcons are prepared to have Penix make his 2026 debut just yet. Depending how the injury report shakes out Friday, Strand could be in the No. 2 role yet again for the Falcons as they host the Panthers.
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Sam Darnold QB | SEA
Seahawks' Sam Darnold: Won't play in Week 2
Coach Mike Macdonald said Darnold (glute) won't play in Sunday's game at Arizona, Curtis Crabtree of Fox 13 Seattle reports.
Darnold lasted just five plays into the Seahawks' Super Bowl defense before leaving last Wednesday's Week 1 matchup with the Patriots due to what was initially described as a hip injury. After a series of updates since then, Darnold is believed to be tending to a "very unique" glute injury that is accompanied by a recovery timetable of four weeks, per Mike Garafolo of NFL Network. For as long as Darnold is sidelined, Drew Lock will direct Seattle's offense.
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Drew Lock QB | SEA
Seahawks' Drew Lock: Will start Week 2
Lock will start Week 2 against the Cardinals with Sam Darnold (glute) unavailable, Curtis Crabtree of Fox 13 in Seattle reports.
Darnold will miss Week 2 as expected, prompting the Seahawks to tab Lock as the starter. Lock was competent in relief of Darnold in the season opener, completing 16 of 22 passes for 187 yards and a touchdown. Importantly, Lock was clean on the turnover front. He will lead the Seahawks for at least the upcoming road game against the Cardinals, which puts him on the radar in superflex and two-quarterback formats.
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Kyler Murray QB | MIN
Vikings' Kyler Murray: Will be limited Wednesday
Coach Kevin O'Connell said Murray (concussion) will be limited at Wednesday's practice, Dane Mizutani of the St. Paul Pioneer Press reports.
Murray lasted 11 offensive snaps before suffering a concussion this past Sunday against the Packers when he was sandwiched between two defenders. Carson Wentz came on in relief of Murray and helped lead the Vikings to a 39-22 victory. O'Connell told Alec Lewis of The Athletic on Monday that Murray would be evaluated day by day as the team prepares for Sunday's road matchup with the Bears, but if the quarterback doesn't make the requisite progress and gain clearance from an independent neurologist, Wentz again will be under center for Minnesota.
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Joe Burrow QB | CIN
Bengals' Joe Burrow: May be dealing with injury
Burrow wasn't involved in the team stretch and didn't make any throws of substance during Wednesday's practice, Kelsey Conway of The Cincinnati Enquirer reports.
Prior to the stretch, Burrow made throws of roughly 15 yards apart along with backup QB Joe Flacco, per Paul Dehner Jr. of The Athletic. Dehner added that head coach Zac Taylor said Monday that some Bengals would be limited in practice this week, but none of those health concerns were major. Burrow is scheduled to speak with the media Wednesday afternoon, while Cincinnati will post its first Week 2 injury report imminently, so clarity on his situation should arrive in the near future.
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Tua Tagovailoa QB | ATL
Falcons' Tua Tagovailoa: Not practicing Wednesday
Coach Kevin Stefanski said Tagovailoa (oblique) won't take part in Wednesday's practice, Marc Raimondi of ESPN.com reports.
Tagovailoa missed the Falcons' Week 1 loss at Pittsburgh due to an oblique strain that he suffered in practice last Thursday. He hasn't practiced in the meantime, but he still will have two more sessions this week to mix into drills and potentially gain clearance to play Sunday against the Panthers. If Tagovailoa isn't able to do so and Michael Penix (knee) remains sidelined, Cooper Rush likely would be the Falcons' starting QB in Week 2.
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Carson Wentz QB | MIN
Vikings' Carson Wentz: To start if Murray unavailable
Wentz "is likely to start" Sunday against the Bears if Kyler Murray does not clear concussion protocol, Dan Graziano of ESPN.com reports.
Wentz was named the backup quarterback last week and led the Vikings to a Week 1 comeback victory over the Packers, so although fellow reserve J.J. McCarthy would also be an option, Wentz appears to be the favorite to get the nod should Murray be unable to go.