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Gabriel Arias SS | CHC
Guardians' Gabriel Arias: Could be out up to eight weeks
The Guardians announced Wednesday that Arias has been diagnosed with a moderate left hamstring strain and is expected to be out for 4-to-8 weeks, Tim Stebbins of MLB.com reports.
As expected, Arias will be on the injured list for well beyond the minimum 10 days after suffering the injury during Monday's 4-2 loss to the Royals. While Arias is on the shelf through at least early-to-mid May, Brayan Rocchio is expected to serve as Cleveland's full-time shortstop, while Daniel Schneemann and Juan Brito could form a platoon at second base.
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Gunnar Henderson SS | BAL
Orioles' Gunnar Henderson: Launches fourth homer
Henderson went 2-for-4 with a two-run home run in Tuesday's 4-2 win against the White Sox.
Henderson broke the tie with his fourth home run of the season in the eighth inning with a two-run shot off Chris Murphy, providing the decisive runs in Baltimore's win. The 24-year-old has been locked in at the plate lately, homering in three of his last five games while going 7-for-20 with five RBI, five runs scored and a 1.285 OPS over that stretch. After a down year power-wise in 2025, when he hit 17 homers across 651 plate appearances, Henderson is beginning to look more like his former self again at the plate.
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Zack Kelly RP | BOS
Red Sox's Zack Kelly: Succeeds in high-leverage spot
Kelly retired both batters he faced in the seventh inning to earn a hold in Tuesday's 3-2 win over Milwaukee.
Kelly entered a high-leverage situation that might normally be entrusted to Justin Slaten, but Slaten was unavailable due to an oblique injury. With Boston leading, 3-1, the bases loaded and one out, Kelly limited the damage to one run on a pair of groundouts and recorded his first hold. In three appearances since being called up from Triple-A Worcester last week, the right-handed reliever has allowed one run and one hit while striking out one over 2.2 innings. The 31-year-old Kelly is a well-known commodity in the bullpen, having made 98 appearances for the Red Sox over the previous four seasons.
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Ryan Helsley RP | BAL
Orioles' Ryan Helsley: Grabs fourth save
Helsley picked up the save in Tuesday's win against the White Sox, allowing one walk while striking out two over a scoreless inning.
Helsley entered the ninth with a two-run lead and issued a leadoff walk to Dustin Harris but quickly regained control, retiring the next three batters, including two via strikeout. While the righty has now converted four saves, his 4.15 ERA, 2.08 WHIP and 7:4 K:BB in 4.1 innings reflect his inconsistency lately. Still, outings like Tuesday's offer a positive sign as Helsley looks to settle into a more reliable groove moving forward.
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Marcell Ozuna DH | PIT
Pirates' Marcell Ozuna: On bench again Wednesday
Ozuna is out of the lineup for Wednesday's game against the Padres.
For the third time in four games, Ozuna will hit the bench after getting off to a porous start to the season. Over 35 plate appearances, the veteran slugger is slashing just .065/.171/.065. Ozuna is still walking at a 11.4 percent clip, and his strikeout rate sits at a manageable 22.9 percent, so he'll have some hope for a turnaround if he can benefit from some better luck on balls in play.
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William Contreras C | MIL
Brewers' William Contreras: Getting breather Wednesday
Contreras is out of the lineup for Wednesday's contest in Boston.
Contreras will get his first true off day of the season; the only other time he was out of the lineup came during the second leg of a doubleheader this past weekend. Gary Sanchez will start at catcher and bat fifth in Wednesday's rubber match.
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Brice Turang 2B | MIL
Brewers' Brice Turang: Remains out Wednesday
Turang (ankle) is out of the lineup for Wednesday's game in Boston.
Turang has been battling tendinitis in his left ankle, which has nagged him for the last several days. He'll be on the bench for a second day in a row, and he'll receive an additional day of rest with the Brewers being idle Thursday. Per Curt Hogg of the Milwaukee Journal Sentinel, Turang believes he'll be ready to go when the Brewers begin a homestand Friday. David Hamilton will handle second base for Milwaukee on Wednesday.
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Henry Davis C | PIT
Pirates' Henry Davis: Receiving breather Wednesday
Davis is out of the lineup for Wednesday's game against the Padres.
After starting behind the plate in each of the Pirates' last three games, Davis will get a breather as Pittsburgh concludes its homestand with a day game after a night game. Joey Bart will catch for starting pitcher Mitch Keller on Wednesday.
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Konnor Griffin SS | PIT
Pirates' Konnor Griffin: Getting day off Wednesday
Griffin is not in the lineup for Wednesday's game versus the Padres.
The Pirates announced the signing of Griffin to a nine-year, $140 million contract earlier in the day, but they'll give him a day off in Wednesday's rubber match with the Padres. Nick Gonzales will cover shortstop and bat sixth for Pittsburgh.
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Kyle Isbel CF | KC
Royals' Kyle Isbel: Absent from lineup vs. LHP
Isbel is out of the lineup for Wednesday's game against the Guardians.
The left-handed-hitting Isbel has now been left out of the lineup three times through the Royals' first 12 games, with all of his absences coming against left-handed starters. Lane Thomas will step in for Isbel in center field Wednesday, and the two players appear likely to work in a platoon for the foreseeable future.