Ryan (0-1) allowed five runs on nine hits and struck out three without walking a batter over four innings to take the loss Wednesday versus the Royals.

Ryan didn't give up a ton of hard contact, but the Royals strung together a three-run tally in the second inning and added an additional run in the third and fourth frames. The right-hander exited at 77 pitches (49 strikes) in a disappointing follow-up to his 5.1 scoreless innings versus the Orioles on Opening Day. Ryan's keeping the walks down with a 10:2 K:BB over 9.1 innings so far, but he will need to avoid putting traffic on the bases, which can bite him if an opponent can generate some power against the flyball pitcher. Ryan is tentatively lined up to make his next start at home in a tough matchup versus the Tigers early next week, which could be the first outing of a two-start week for the Twins' ace.

Yamamoto (1-1) allowed two runs on four hits, a walk and a hit-by-pitch while striking out two over six innings to take the loss versus the Guardians on Wednesday.

Yamamoto was outdueled by Gavin Williams, who struck out 10 over seven scoreless innings. Yamamoto's missteps came in the third inning, as Daniel Schneemann doubled, stole third and scored on an errant throw before Gabriel Arias went yard for a solo home run. This was still a second straight quality start for Yamamoto, who has allowed four runs on nine hits and one walk with eight strikeouts over 12 innings in his first two outings of the season. The star right-hander allowed just 14 home runs over 173.2 regular-season innings across 30 starts last season, so he should be able to get that under control after giving up a long ball in each of his starts in 2026. The Dodgers are using a six-man rotation for the week ahead, but with extra rest built in for Shohei Ohtani, Yamamoto is tentatively projected to make his next start in Toronto.

Williams (1-1) allowed two hits and three walks while striking out 10 over seven scoreless innings to earn the win over the Dodgers on Wednesday.

Williams looks to have corrected the mechanical issue that led to him walking six batters in his season debut versus the Mariners. The right-hander was excellent in this contest, though he's unlikely to ever be an elite control pitcher. That didn't get in his way in 2025, and he's now given up a modest three runs over 12 innings while posting a 17:9 K:BB through his first two starts of 2026. Williams is projected to make his next start at home versus the Royals next week.

Kirby (1-1) took the loss Wednesday against the Yankees, allowing four runs on five hits and three walks in six innings. He struck out six.

The right-hander gave up just one run through five frames, but Paul Goldschmidt's three-run homer in sixth inning left a big mark on Kirby's ledger. Kirby has now gone at least six innings in each of his first two starts of the year, but he's now been taken deep twice already. Kirby will be trying to keep the ball in the yard the next time he takes the mound, which is set come in Texas versus the division-rival Rangers next week.

Schlittler (2-0) notched the win Wednesday against the Mariners, allowing no runs on two hits and no walks in 6.1 innings. He struck out seven.

After giving up just one hit in his season debut against the Giants, Schlitter was nearly unhittable again Wednesday. The Mariners offered very little resistance against the right-hander, who pounded the zone for 58 strikes out of his 79 pitches while posting a strong 13 swings and misses. Schlittler has a shiny 15:0 K:BB through his first 11.2 frames of 2026, and he'll be looking to touch the 80-pitch marker for the first time this year in his next scheduled outing against the Athletics.

The Dodgers transferred Stone (shoulder) to the 60-day injured list Wednesday.

Stone opened the regular season on the 15-day IL after suffering a setback with his surgically repaired right shoulder during spring training. The Dodgers are taking a slow approach to the right-hander's rehab, with manager Dave Roberts relaying to reporters Wednesday that Stone is "starting over a spring ramp-up," and the move to the 60-day IL means he won't be available to make his 2026 debut until at least late May, per Fabian Ardaya of The Athletic. In a corresponding move, the Dodgers claimed Grant Holman off waivers from the Diamondbacks.

Miller allowed a hit and struck out three without walking a batter over 1.1 scoreless innings to earn the save in Wednesday's 7-1 win over the Giants.

Miller entered the game with one on and two outs in the eighth inning and shut things down. The Padres proceeded to add four runs in their half of the eighth to give Miller plenty of cushion. This was his second save of the season, and he's added a 5:1 K:BB over 2.1 scoreless innings so far. He is firmly locked into the closer role, and Wednesday's outing shows manager Craig Stammen won't hesitate to ask him to cover more than one frame if necessary.

Houser (0-1) allowed three runs (one earned) on seven hits and a walk while striking out four over 5.1 innings to take the loss Wednesday versus the Padres.

The Giants' defense didn't do Houser any favors, with errors in the first and fifth innings lead to the first two runs on his line. This was the right-hander's Giants debut, and he threw 58 of 86 pitches for strikes in a decent performance. He signed in San Francisco for two years and $22 million after splitting last season between the Rays and the White Sox, posting a 3.31 ERA, 1.28 WHIP and 92:38 K:BB across 125 innings over 21 starts in a bounce-back season. He has a good park, but the Giants' offense hasn't been all that encouraging with just 13 runs scored over six games this season. Houser is tentatively lined up to make his next start at home versus the Phillies next week, which could set him up for a two-start week.

Butto was removed during the eighth inning of the Giants' 7-1 loss to the Padres on Wednesday due to right arm tightness, Justice delos Santos of The San Jose Mercury News reports.

Butto was brought in for the eighth to keep the Giants' deficit at two runs, but he recorded just one out while allowing four runs on three hits and four walks, tossing 28 pitches (eight strikes) before being pulled. The Giants should have an update over the next couple of days once Butto undergoes further tests on his arm.

Gallen (1-1) notched the win Wednesday against the Tigers, allowing no runs on four hits and no walks in six innings. He struck out two.

Two of the hits allowed went for extra bases, but Gallen was still able to keep Detroit out of the scoring column Wednesday. Although right-hander wasn't dominant, he tossed 58 of his 88 pitches for strikes and bounced back in a big way after allowing four runs in four innings during his season debut. Gallen is set for a tough matchup on paper versus the Mets in his next scheduled start, though New York has stumbled out of the gates with .648 OPS as a team through six games thus far.