Gilbert struck out in one-third of an inning for the save Wednesday against the Rays.

It's worth noting Jordan Leasure worked the seventh inning Wednesday, which created the opportunity for Gilbert to tally the first save of his career. It's possible the last-place White Sox will continue to mix and match their ninth-inning options, which would further make this a situation to avoid for most fantasy managers. Through 43 innings this season, Gilbert has a 4.40 ERA, 1.33 WHIP and 39:21 K:BB.

Holton will serve as the Tigers' opening pitcher for Thursday's game against the Yankees, Chris McCosky of The Detroit News reports.

Holton will receive his sixth opening assignment of the season Thursday and his first since July 2. The 29-year-old southpaw owns a 3.86 ERA and 1.12 WHIP through 67.2 frames, and he likely will remain in the game for just an inning or two before turning the ball over to Sawyer Gipson-Long, who is expected to work in a bulk-relief role.

Estevez picked up the save in Wednesday's 4-3 win over the Guardians, tossing a perfect ninth inning.

Called upon in the ninth to protect a one-run lead, Estevez extended his scoreless streak to 10 appearances while converting his MLB-leading 39th save of the season. The veteran right-hander is now on the verge of becoming just the eighth Royal to ever reach the 40-save mark in a single campaign and the first since 2014. Estevez has been a model of consistency at the back end of Kansas City's bullpen, posting a 2.45 ERA, 1.04 WHIP and 52:21 K:BB across 62.1 innings this year.

Kittredge picked up the save Wednesday against Atlanta, striking out one in a clean ninth inning.

It's notable that Kittredge saw Chicago's first save opportunity since closer Daniel Palencia (shoulder) landed on the injured list. That usage would appear to put him first in line for future save chances, though it's certainly still possible that manager Craig Counsell has a committee approach in mind for his closer position for the time being. Kittredge is worth a speculative add in most fantasy formats as this situation unfolds -- the veteran right-hander owns a 3.45 ERA, 1.00 WHIP and 52:10 K:BB through 47 innings on the season.

Abreu picked up the save Wednesday against Toronto, striking out one in a clean ninth inning.

One night after blowing a save against the Blue Jays, Abreu rebounded with his fifth save of the season Wednesday. The hard-throwing right-hander has fanned at least one in nine consecutive outings, and he remains in position to close out the regular season as Houston's stopper in the absence of closer Josh Hader (shoulder). Through 66 frames this year, Abreu has a 2.45 ERA, 1.12 WHIP and 101:29 K:BB.

Taylor was removed from Wednesday's game against the Rays with a right groin strain.

The White Sox turned to Taylor in a save situation Wednesday, but he had to come out of the game after throwing just seven pitches with decreased velocity. The White Sox will further evaluate him Thursday, at which point more details regarding the severity of his injury may be revealed. If he requires a stint on the IL, his absence could lead to more high-leverage work for Brandon Eisert or Steven Wilson going forward.

The Nationals optioned Ribalta to Triple-A Rochester on Wednesday.

Since being promoted into Washington's bullpen Aug. 1, Ribalta has turned in a 5.27 ERA and 1.90 WHIP alongside a 15:11 K:BB across 13.2 innings. The 27-year-old's subpar performance will now cause him to return to the minors in anticipation of MacKenzie Gore's (shoulder) return from the injured list Thursday.

Seymour (1-3) took the loss Wednesday against the Diamondbacks, allowing four runs on six hits across 1.1 innings. He struck out one.

It was a rough day for Seymour, who gave up a home run to Geraldo Perdomo to lead off the game before giving up three more runs before departing with one out in the second. The 26-year-old Seymour has given up nine runs across 9.1 innings in three starts with the Giants. He's currently scheduled to face the Diamondbacks again in his next outing, though he could return to the bullpen when Carson Whisenhunt (back) is able to rejoin the rotation.

Jansen struck out two in a perfect ninth inning Wednesday to record his 27th save of the season in a 4-3 win over the Twins.

The veteran closer has converted 12 straight save chances since the beginning of July, posting a 1.37 ERA, 0.65 WHIP and 26:7 K:BB in 26.1 innings over that stretch while also adding four wins. Jansen is up to 474 saves for his career, leaving him four behind Hall of Famer Lee Smith for third place on the all-time list.

Chapman (4-3) took the loss Wednesday against the A's, allowing a run on two hits in one-third of an inning.

Shea Langeliers led off the bottom of the ninth inning with a double, the first hit given up by Chapman since July 23, a span of 14.2 innings. Langeliers would advance to third on a sacrifice fly before Chapman gave up a game-winning single to Lawrence Butler. Despite the hiccup Wednesday, it's been an incredible season for the 37-year-old Chapman, who sports a sparkling 1.14 ERA, 0.67 WHIP and 81 strikeouts over 55.1 innings.