O'Brien picked up his first save of the season in Tuesday's 3-0 win over the Mets. He didn't allow a hit or a walk with no strikeouts in a scoreless ninth inning.

It's notable that manager Oliver Marmol went to O'Brien for the ninth inning after the Cardinals' first two save chances of the season were given to Ryne Stanek in the opening series against the Rays. Stanek pitched the seventh inning against the Mets on Tuesday, walking one and striking out one in a scoreless frame. Stanek's save chances have been a rollercoaster, as he walked three on Opening Day and blew the save the following game, only to pick up the win later. O'Brien was effective in the role last season after Ryan Helsley was dealt at the trade deadline. The 31-year-old O'Brien turned in a 2.06 ERA, 1.15 WHIP and 45:22 K:BB across 48 innings last regular season and picked up all six of his saves following Helsley's departure. The Cardinals figure to give O'Brien, Stanek and JoJo Romero save opportunities this season.

Pallante (1-0) picked up the win against the Mets on Tuesday after throwing five scoreless innings, allowing just three hits and three walks while striking out three.

Pallante didn't have his best stuff by any means, but the Mets' bats were quiet and couldn't find any holes in the St. Louis defense. Pallante is a back-of-the-rotation type who isn't going to miss many bats and needs his defense, making him an uninteresting mixed-league option ahead of next week's road date with the Nationals.

Leiter earned the save in Monday's 5-2 win over Atlanta, allowing two hits while striking out one batter in one inning. He did not issue a walk.

Leiter was brought out for the ninth inning to protect the Athletics' three-run lead. He yielded hits to two of the first three batters he faced but bounced back to strike out Ronald Acuna before getting Drake Baldwin to pop out to second. Leiter is competing against Scott Barlow and Hogan Harris for the Athletics' closer job, but Leiter has earned the first save of the season for the organization, with Barlow blowing his opportunity against the Blue Jays on Saturday.

The Mariners designated Loutos for assignment Tuesday, Adam Jude of The Seattle Times reports.

The move opens up a 40-man roster spot for Colt Emerson, who inked an eight-year, $95 million extension earlier Tuesday. Loutos failed to earn a spot on the Mariners' Opening Day roster after allowing seven runs (six earned) on seven hits across three innings during Cactus League action.

The Blue Jays recalled Estrada from Triple-A Buffalo on Tuesday.

The move has been in the works for the last 24 hours after Cody Ponce suffered a sprained right ACL in Monday's start against Colorado. Estrada will be an option to step into Ponce's spot in the rotation this upcoming weekend, but he's also likely available in relief the next couple days. Estrada appeared in two regular-season games with Toronto last season, surrendering seven runs on 10 hits and one walk across 7.1 innings of work. He struck out 10 and hit two batters.

The Blue Jays placed Ponce (knee) on the 15-day injured list Tuesday.

Ponce's absence is expected to be much longer than the minimum 15 days, as manager John Schneider said earlier Tuesday that the right-hander will miss "significant time" with a sprained right ACL that he suffered in Monday's start against the Rockies. In a corresponding move, Toronto recalled Lazaro Estrada from Triple-A. The Blue Jays will need to continue to piece their rotation together until some of their starters get healthy.

Ponce (knee) has been diagnosed with a sprained right ACL and is expected to miss "significant time," Mitch Bannon of The Athletic reports.

The Blue Jays remain optimistic that Ponce can pitch again this season, but manager John Schneider said doctors will continue to review Ponce's MRI and determine if surgery is needed. It's a brutal blow for Ponce, who inked a three-year, $30 million deal with Toronto this past offseason after spending three seasons overseas. Ponce's injury also further tests the pitching depth of the Blue Jays, who are already dealing with injuries to Jose Berrios (elbow), Shane Bieber (elbow) and Trey Yesavage (shoulder) in the rotation. Ponce is likely to be shut down for quite some time.

Zastryzny (shoulder) will begin a rehab assignment with Triple-A Nashville on Tuesday, Jack Stern of BrewerFanatic.com reports.

Zastryzny has been shelved since mid-March due to a left shoulder strain, but he's been cleared to test things out in a game setting. The southpaw reliever is eligible for activation from the 15-day injured list April 6, and he has a good shot to be ready to go on that date.

Brash (1-0) earned the win Monday over the Yankees, allowing one hit while logging a strikeout in a scoreless inning.

Brash kept the Yankees off the board in the top of the ninth inning, working around a Giancarlo Stanton one-out double before the Mariners delivered a walk-off win in the bottom half of the frame. Brash has held opponents scoreless through his first two appearances (two innings) this season, allowing two hits and no walks. The right-hander is a key high-leverage option for Seattle ahead of closer Andres Munoz. Brash posted a 2.47 ERA with a 1.25 WHIP and 58:18 K:BB in 47.1 regular-season innings last year, totaling four saves and 21 holds.

Henry gave up a hit and a walk in a scoreless ninth inning during Monday's win over the Phillies. He struck out one.

The right-hander entered the game with the Nationals cruising to a 13-2 rout. Henry's made two appearances so far, and both came in blowouts -- he also delivered a scoreless inning in Saturday's 10-2 loss to the Cubs. Henry was viewed as potentially part of the closing picture coming into the season alongside Clayton Beeter, but his early usage suggests he's a long way from a high-leverage role.