Manzardo went 2-for-4 with a solo home run in Friday's 6-0 win over the Phillies.

The 24-year-old slugger opened the scoring in the fourth inning by driving an Aaron Nola fastball 411 feet to straightaway center field. Manzardo is emerging as a desperately needed power source for Cleveland, and through 33 games he's slashing .221/.326/.504 with nine homers, 16 runs and 22 RBI.

Santander isn't in the lineup for Friday's game against the Mariners.

Santander will get a breather during Friday's series opener after going 5-for-14 with a homer and four RBI during Toronto's previous series in Anaheim. His absence will put George Springer in the DH spot while Jonatan Clase picks up a start in left field, batting ninth.

Lewis is not in the lineup for Friday's game against the Giants.

Lewis made his season debut Tuesday and started all three games against the Orioles, going 0-for-9 with one strikeout and one walk. He'll get a breather against Giants right-hander Jordan Hicks. Brooks Lee is making the start at third base and batting in the cleanup spot for Minnesota.

Devers said Thursday that he declined a request from team management to play first base, Ken Powtak of MLB.com reports. "They had the conversation with me," Devers said through a team interpreter. "I don't think, for me personally, it's the best decision after they asked me to play a different position."

Alex Cora had previously indicated he wasn't even going to ask Devers if he would be willing to move from designated hitter to first base, and instead, the manager allowed Red Sox chief baseball officer Craig Breslow to make the request. After a slow start to the season, Devers has been locked in at the plate since late April, going 18-for-47 with four home runs, four doubles, 11 RBI and eight runs scored over the last 12 games. Devers' insistence on not switching positions leaves Boston without a clear starter at first base in the wake of a season-ending knee injury to Triston Casas.

Diaz went 1-for-5 with a three-run home run Thursday against the Phillies.

Diaz slotted into the leadoff spot for the second straight game since returning from a hip injury -- both of which came against lefties. He popped his sixth home run of the season in the seventh inning, his third in his last seven games. Diaz now has a .174 ISO across 163 plate appearances, which would be good for the second-highest mark of his career.

Malloy went 3-for-5 with a double, a walk, four RBI and one run scored across both games of Thursday's doubleheader sweep over the Rockies.

Malloy got a rare start in right field in the day game, and he went 2-for-4 and with an RBI single in the third inning. He added a three-run double late in the nightcap. Malloy has mostly functioned as a short-side platoon option, sharing right field with lefty-hitting Zach McKinstry and Kerry Carpenter. Prior to Thursday, Malloy had gone 0-for-12 with three walks over his previous nine games. He's hitting .200 with one home run, 12 RBI, 10 runs scored and no stolen bases over 84 plate appearances.

Pederson went 2-for-2 with a double and a walk in Wednesday's 6-4 loss to Boston.

Pederson recorded multiple hits for a second straight game and is a combined 4-for-5 with two doubles, one walk and an RBI in the first two games of the series with the Red Sox. It's just the second time all season he's hit safely in consecutive contests. He still has a way to go to dig out of an epic season-starting slump -- his average was .052 on April 22 -- but Pederson is batting .281 (9-for-32) over the last 12 games, and the bat is showing signs of life.

Diaz (hip) will serve as the Rays' designated hitter and leadoff batter in Wednesday's game against the Phillies, Ryan Bass of FanDuel Sports Network Sun reports.

Diaz exited Tuesday's 8-4 win early due to right hip tightness, but he downplayed the injury after the game and suggested he would be back in action Wednesday. His prediction appears to have come true, and he'll move up to the top of the order after having occupied the No. 3 spot in his previous two starts. The left-handed-hitting Chandler Simpson could continue to bat leadoff against right-handed pitching, but Diaz looks like he'll be the Rays' preferred table setter versus lefties such as the Phillies' Cristopher Sanchez.

Polanco will serve as the Mariners' designated hitter and No. 2 batter in Wednesday's game against the Athletics.

In Tuesday's 5-3 win, Polanco drew a start at second base, which marked his first start in the infield since April 4. Polanco had been limited to DH duties for the past month while managing a side injury that affects his throwing and inhibits him when he bats from the right side of the plate, but his usage at the keystone offers hope that he may be nearing the finish line in his recovery. The Mariners plan to have Polanco serve as their everyday third baseman once the injury is fully behind him, but he may have started at second base Tuesday due to the shorter throws that he would need to make at the position.

Astros manager Joe Espada said Wednesday that Alvarez has been diagnosed with a muscle strain on the top of his right hand and is hoping to be activated from the 10-day injured list when first eligible May 13, Brian McTaggart of MLB.com reports.

Alvarez needs a bit of rest, but the goal is for him to rejoin the Astros early next week for the second game of a three-game set against the Royals. Jose Altuve has made two starts at designated hitter and Yainer Diaz has been in the DH spot once since Alvarez was placed on the IL on Monday.