Week 1 NFL odds, lines, betting picks, spreads, best bets, 2025 predictions: Model loves Bengals, Packers

Some bettors like to jump on NFL lines early, while others wait until right at kickoff in the search for maximum value. Whichever NFL betting strategy you prefer, you'll have a host of close NFL odds to deal with as there are nearly a dozen NFL games with a line of a field goal or less. Some of these NFL odds include Jets vs. Steelers (-3), 49ers vs. Seahawks (+2.5), Packers vs. Lions (+1.5) and Rams vs. Texans (+2.5). There's just one contest with Week 1 NFL spreads of over a touchdown as it will see Cam Ward make his pro debut as his Titans are 7.5-point underdogs to the Broncos.

Whatever NFL betting trends you decide to follow for the opening slate of games, you certainly want your football bets to kick off the 2025 NFL season to start off on the right note. All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now. Bet on every NFL Week 1 game at DraftKings Sportsbook, where new users can target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks its since inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 1 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick. New users can also bet NFL Week 1 at bet365 and get $150 in bonus bets instantly:

Top Week 1 NFL predictions

We can tell you one of the model's strongest Week 1 NFL picks is that the Bengals (-5.5, 46.5) cover the spread on the road versus the Browns. We don't know who will start under center for Cleveland, but it may not even matter because we do know who will be under center for the Bengals. Joe Burrow led the league in both passing yards (4,918) and passing touchdowns (43) a year ago as he became the third player in NFL history to have at least 4,500 yards, 40 touchdowns and fewer than 10 interceptions. After signing both Ja'Marr Chase and Tee Higgins to extensions this offseason, the league's No. 1 passing offense from a year ago returns intact.

Cincy's passing game, alone, may put more points on the game than Cleveland, which ranked dead-last in scoring in 2024. Cleveland struggled in all facets, with the last-ranked third-down offense, committing the second-most turnovers, and having bottom-five rankings in both rushing offense and redzone scoring. Plus, the Browns' defense slipped considerably from the unit which led the NFL in yards allowed in 2023 as Cleveland ranked 27th in points allowed in 2024. The model projects a double-digit victory for Cincinnati (-5.5), which covers well over 50% of the time. See which other teams to pick here.

Another one of its Week 1 NFL predictions: the Packers (-1.5, 49.5) cover at home versus the Lions. The Commanders may have revealed the blueprint to exploiting Detroit, courtesy of Washington's road playoff win last season. Jared Goff was often pressured, which led to him turning the ball over four times, and few teams apply pressure or create takeaways quite like Green Bay. It ranked fourth in turnovers created a year ago, and just seven teams racked up more sacks, despite the Packers blitzing at the second-lowest rate in the league.

One also can't forget the offseason attrition for Detroit, which lost both of its coordinators, as well as three-time All-Pro center Frank Ragnow. The Packers, meanwhile, added the one thing it was missing in a No. 1 wideout by drafting Matthew Golden in the first round. The model projects him to make an immediate impact by leading the Packers in receiving in Week 1, while Green Bay's defense has both more sacks and more takeaways than Detroit on defense. With that, the Packers (-1.5) cover well over 50% of the time, with the Over (49.5) hitting in over 50% of simulations. See which other teams to pick here.

How to make Week 1 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 1 NFL schedule and just revealed three underdogs that outright win, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which three teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 1 NFL betting odds, lines, live spreads, scores

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